High circulating follistatin-like protein 1 as a biomarker of a metabolically unhealthy state

Sun Young Lee, Deog Yoon Kim, Mi Kyung Kwak, Seong Hee Ahn, Hyeonmok Kim, Beom Jun Kim, Jung Min Koh, Yumie Rhee, Chong Hwa Kim, Ki Hyun Baek, Yong Ki Min, Seung Hun Lee, Moo Il Kang

Research output: Contribution to journalArticle

Abstract

The inflammatory biomarkers that fully characterize the metabolically unhealthy (MU) state-which is a risk factor for cardiovascular disease (CVD)-remain unclear. Recent studies suggest follistatin-like protein 1 (FSTL1) could be used as a biomarker for inflammation and CVD, however there is little information on FSTL1 levels in the MU state. We aimed to evaluate the associations between FSTL1, the presence of MU state and subclinical coronary atherosclerosis. In a cross-sectional study, we evaluated FSTL1 levels and their relationship with the presence of MU state and coronary artery plaques in 230 Korean patients. Significant increase in FSTL1 levels was observed in subjects with MU state (p = 0.020), but not those with obesity state according to body mass index criteria (p = 0.790). After adjusting for confounders, the odd ratio (OR) for the MU state among patients in the highest FSTL1 tertile (T3) was higher in comparison with the lowest tertile (T1) (OR = 3.60, 95% confidence interval [95% CI] = 1.20-10.83). In a subgroup (n = 66), FSTL1 levels were also marginally higher in patients with plaques (p = 0.098). The OR for plaque presence in patients with T3 was significantly higher in comparison with T1 after adjusting for confounders (OR = 12.51, 95% CI = 1.15-135.73). Plasma FSTL1 may be a useful biomarker for the risk of MU state and CVD.

Original languageEnglish
Pages (from-to)241-251
Number of pages11
JournalEndocrine Journal
Volume66
Issue number3
DOIs
Publication statusPublished - 2019 Jan 1

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Follistatin-Related Proteins
Biomarkers
Odds Ratio
Cardiovascular Diseases
Confidence Intervals
Coronary Artery Disease
Coronary Vessels
Body Mass Index
Obesity
Cross-Sectional Studies

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Lee, S. Y., Kim, D. Y., Kwak, M. K., Ahn, S. H., Kim, H., Kim, B. J., ... Kang, M. I. (2019). High circulating follistatin-like protein 1 as a biomarker of a metabolically unhealthy state. Endocrine Journal, 66(3), 241-251. https://doi.org/10.1507/endocrj.EJ18-0352
Lee, Sun Young ; Kim, Deog Yoon ; Kwak, Mi Kyung ; Ahn, Seong Hee ; Kim, Hyeonmok ; Kim, Beom Jun ; Koh, Jung Min ; Rhee, Yumie ; Kim, Chong Hwa ; Baek, Ki Hyun ; Min, Yong Ki ; Lee, Seung Hun ; Kang, Moo Il. / High circulating follistatin-like protein 1 as a biomarker of a metabolically unhealthy state. In: Endocrine Journal. 2019 ; Vol. 66, No. 3. pp. 241-251.
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abstract = "The inflammatory biomarkers that fully characterize the metabolically unhealthy (MU) state-which is a risk factor for cardiovascular disease (CVD)-remain unclear. Recent studies suggest follistatin-like protein 1 (FSTL1) could be used as a biomarker for inflammation and CVD, however there is little information on FSTL1 levels in the MU state. We aimed to evaluate the associations between FSTL1, the presence of MU state and subclinical coronary atherosclerosis. In a cross-sectional study, we evaluated FSTL1 levels and their relationship with the presence of MU state and coronary artery plaques in 230 Korean patients. Significant increase in FSTL1 levels was observed in subjects with MU state (p = 0.020), but not those with obesity state according to body mass index criteria (p = 0.790). After adjusting for confounders, the odd ratio (OR) for the MU state among patients in the highest FSTL1 tertile (T3) was higher in comparison with the lowest tertile (T1) (OR = 3.60, 95{\%} confidence interval [95{\%} CI] = 1.20-10.83). In a subgroup (n = 66), FSTL1 levels were also marginally higher in patients with plaques (p = 0.098). The OR for plaque presence in patients with T3 was significantly higher in comparison with T1 after adjusting for confounders (OR = 12.51, 95{\%} CI = 1.15-135.73). Plasma FSTL1 may be a useful biomarker for the risk of MU state and CVD.",
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Lee, SY, Kim, DY, Kwak, MK, Ahn, SH, Kim, H, Kim, BJ, Koh, JM, Rhee, Y, Kim, CH, Baek, KH, Min, YK, Lee, SH & Kang, MI 2019, 'High circulating follistatin-like protein 1 as a biomarker of a metabolically unhealthy state', Endocrine Journal, vol. 66, no. 3, pp. 241-251. https://doi.org/10.1507/endocrj.EJ18-0352

High circulating follistatin-like protein 1 as a biomarker of a metabolically unhealthy state. / Lee, Sun Young; Kim, Deog Yoon; Kwak, Mi Kyung; Ahn, Seong Hee; Kim, Hyeonmok; Kim, Beom Jun; Koh, Jung Min; Rhee, Yumie; Kim, Chong Hwa; Baek, Ki Hyun; Min, Yong Ki; Lee, Seung Hun; Kang, Moo Il.

In: Endocrine Journal, Vol. 66, No. 3, 01.01.2019, p. 241-251.

Research output: Contribution to journalArticle

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T1 - High circulating follistatin-like protein 1 as a biomarker of a metabolically unhealthy state

AU - Lee, Sun Young

AU - Kim, Deog Yoon

AU - Kwak, Mi Kyung

AU - Ahn, Seong Hee

AU - Kim, Hyeonmok

AU - Kim, Beom Jun

AU - Koh, Jung Min

AU - Rhee, Yumie

AU - Kim, Chong Hwa

AU - Baek, Ki Hyun

AU - Min, Yong Ki

AU - Lee, Seung Hun

AU - Kang, Moo Il

PY - 2019/1/1

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N2 - The inflammatory biomarkers that fully characterize the metabolically unhealthy (MU) state-which is a risk factor for cardiovascular disease (CVD)-remain unclear. Recent studies suggest follistatin-like protein 1 (FSTL1) could be used as a biomarker for inflammation and CVD, however there is little information on FSTL1 levels in the MU state. We aimed to evaluate the associations between FSTL1, the presence of MU state and subclinical coronary atherosclerosis. In a cross-sectional study, we evaluated FSTL1 levels and their relationship with the presence of MU state and coronary artery plaques in 230 Korean patients. Significant increase in FSTL1 levels was observed in subjects with MU state (p = 0.020), but not those with obesity state according to body mass index criteria (p = 0.790). After adjusting for confounders, the odd ratio (OR) for the MU state among patients in the highest FSTL1 tertile (T3) was higher in comparison with the lowest tertile (T1) (OR = 3.60, 95% confidence interval [95% CI] = 1.20-10.83). In a subgroup (n = 66), FSTL1 levels were also marginally higher in patients with plaques (p = 0.098). The OR for plaque presence in patients with T3 was significantly higher in comparison with T1 after adjusting for confounders (OR = 12.51, 95% CI = 1.15-135.73). Plasma FSTL1 may be a useful biomarker for the risk of MU state and CVD.

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