High-contrast imaging of mycobacterium tuberculosis using third-harmonic generation microscopy

Bo Ram Kim, Eungjang Lee, Seung Han Park

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nonlinear optical microcopy has become an important tool in investigating biomaterials due to its various advantages such as label-free imaging capabilities. In particular, it has been shown that third-harmonic generation (THG) signals can be produced at interfaces between an aqueous medium (e.g. cytoplasm, interstitial fluid) and a mineralized lipidic surface. In this work, we have demonstrated that label-free high-contrast THG images of the mycobacterium tuberculosis can be obtained using THG microscopy.

Original languageEnglish
Title of host publicationInternational Conference on Nano-Bio Sensing, Imaging, and Spectroscopy 2015, NBSIS 2015
EditorsDonghyun Kim, Min-Gon Kim, Seung-Han Park
PublisherSPIE
ISBN (Electronic)9781628416794
DOIs
Publication statusPublished - 2015 Jan 1
Event2nd International Conference on Nano-Bio Sensing, Imaging, and Spectroscopy, NBSIS 2015 - Jeju, Korea, Republic of
Duration: 2015 Feb 252015 Feb 27

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9523
ISSN (Print)1605-7422

Other

Other2nd International Conference on Nano-Bio Sensing, Imaging, and Spectroscopy, NBSIS 2015
CountryKorea, Republic of
CityJeju
Period15/2/2515/2/27

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All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Kim, B. R., Lee, E., & Park, S. H. (2015). High-contrast imaging of mycobacterium tuberculosis using third-harmonic generation microscopy. In D. Kim, M-G. Kim, & S-H. Park (Eds.), International Conference on Nano-Bio Sensing, Imaging, and Spectroscopy 2015, NBSIS 2015 [95230G] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9523). SPIE. https://doi.org/10.1117/12.2187632