High-contrast reversible fluorescence photoswitching of dye-crosslinked dendritic nanoclusters in living vertebrates

Yoonkyung Kim, Hye Youn Jung, Yun Hui Choe, Chaewoon Lee, Sung Kyun Ko, Soonil Koun, Yohan Choi, Bong Hyun Chung, Byoung Chul Park, Tae Lin Huh, Injae Shin, Eunkyoung Kim

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Abstract

Dendrimers crosslinked with a photochromic diarylethene (blue in picture) were labeled with the fluorescent dye Cy3 (red) for reversible fluorescence photoswitching. If the obtained nanoclusters are irradiated with UV light, the Cy3 fluorescence is quenched by the diarylethene in its ring-closed form, whereas upon irradiation with visible light, the nanoclusters show fluorescence. High-contrast fluorescence imaging was achieved inside a living zebrafish.

Original languageEnglish
Pages (from-to)2878-2882
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number12
DOIs
Publication statusPublished - 2012 Mar 19

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All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Kim, Y., Jung, H. Y., Choe, Y. H., Lee, C., Ko, S. K., Koun, S., Choi, Y., Chung, B. H., Park, B. C., Huh, T. L., Shin, I., & Kim, E. (2012). High-contrast reversible fluorescence photoswitching of dye-crosslinked dendritic nanoclusters in living vertebrates. Angewandte Chemie - International Edition, 51(12), 2878-2882. https://doi.org/10.1002/anie.201107086