High-dose versus standard-dose radiation therapy for cervical esophageal cancer: Retrospective single-institution study

Tae Hyung Kim, Ik Jae Lee, Ji Hyun Kim, Chang Geol Lee, Yong Chan Lee, Jun Won Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: To evaluate the role of definitive radiotherapy using higher-than-standard-dose radiation of 50 Gy for carcinoma of the cervical esophagus (CCE). Methods: We reviewed 79 patients with stage I-III CCE, treated between 2000 and 2012. Patients received 5-fluorouracil/cisplatin-based chemotherapy concurrently and were divided into high-dose (≥59.4 Gy, n = 44) and standard-dose (<59.4 Gy, n = 35) groups. Results: The median follow-up was 35 months for surviving patients. The high-dose group had significantly better 3-year local (90.0% vs 60.4%, P =.001) and locoregional (70.4% vs 45.3%, P =.04) control. Progression-free (45.4% vs 37.5%, P =.32) and overall (58.4% vs 49.1%, P =.69) survival rates were not different. High-dose radiation was an independent prognostic factor for locoregional control (P =.04). No differences in late toxicities (esophageal stenosis or tracheoesophageal fistula) were observed. Conclusion: High-dose radiation for CCE improves local and locoregional control, without increasing severe toxicities.

Original languageEnglish
Pages (from-to)146-153
Number of pages8
JournalHead and Neck
Volume41
Issue number1
DOIs
Publication statusPublished - 2019 Jan

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All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

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