Background: To evaluate the role of definitive radiotherapy using higher-than-standard-dose radiation of 50 Gy for carcinoma of the cervical esophagus (CCE). Methods: We reviewed 79 patients with stage I-III CCE, treated between 2000 and 2012. Patients received 5-fluorouracil/cisplatin-based chemotherapy concurrently and were divided into high-dose (≥59.4 Gy, n = 44) and standard-dose (<59.4 Gy, n = 35) groups. Results: The median follow-up was 35 months for surviving patients. The high-dose group had significantly better 3-year local (90.0% vs 60.4%, P =.001) and locoregional (70.4% vs 45.3%, P =.04) control. Progression-free (45.4% vs 37.5%, P =.32) and overall (58.4% vs 49.1%, P =.69) survival rates were not different. High-dose radiation was an independent prognostic factor for locoregional control (P =.04). No differences in late toxicities (esophageal stenosis or tracheoesophageal fistula) were observed. Conclusion: High-dose radiation for CCE improves local and locoregional control, without increasing severe toxicities.
Bibliographical noteFunding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Republic of Korea, Grant/ Award Number: (2017R1D1A1B03035047); Korean Health Industry Development Institute funded by the Ministry of Health and Welfare, Republic of Korea, Grant/Award Number: (HI15C0638)
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