High-dose versus standard-dose radiation therapy for cervical esophageal cancer

Retrospective single-institution study

Tae Hyung Kim, Ik Jae Lee, Ji Hyun Kim, Chang Geol Lee, Yongchan Lee, Jun Won Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: To evaluate the role of definitive radiotherapy using higher-than-standard-dose radiation of 50 Gy for carcinoma of the cervical esophagus (CCE). Methods: We reviewed 79 patients with stage I-III CCE, treated between 2000 and 2012. Patients received 5-fluorouracil/cisplatin-based chemotherapy concurrently and were divided into high-dose (≥59.4 Gy, n = 44) and standard-dose (<59.4 Gy, n = 35) groups. Results: The median follow-up was 35 months for surviving patients. The high-dose group had significantly better 3-year local (90.0% vs 60.4%, P =.001) and locoregional (70.4% vs 45.3%, P =.04) control. Progression-free (45.4% vs 37.5%, P =.32) and overall (58.4% vs 49.1%, P =.69) survival rates were not different. High-dose radiation was an independent prognostic factor for locoregional control (P =.04). No differences in late toxicities (esophageal stenosis or tracheoesophageal fistula) were observed. Conclusion: High-dose radiation for CCE improves local and locoregional control, without increasing severe toxicities.

Original languageEnglish
Pages (from-to)146-153
Number of pages8
JournalHead and Neck
Volume41
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1

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Esophageal Neoplasms
Uterine Cervical Neoplasms
Esophagus
Radiotherapy
Radiation
Esophageal Fistula
Tracheoesophageal Fistula
Radiation Dosage
Esophageal Stenosis
Fluorouracil
Cisplatin
Survival Rate
Carcinoma
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Kim, Tae Hyung ; Lee, Ik Jae ; Kim, Ji Hyun ; Lee, Chang Geol ; Lee, Yongchan ; Kim, Jun Won. / High-dose versus standard-dose radiation therapy for cervical esophageal cancer : Retrospective single-institution study. In: Head and Neck. 2019 ; Vol. 41, No. 1. pp. 146-153.
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abstract = "Background: To evaluate the role of definitive radiotherapy using higher-than-standard-dose radiation of 50 Gy for carcinoma of the cervical esophagus (CCE). Methods: We reviewed 79 patients with stage I-III CCE, treated between 2000 and 2012. Patients received 5-fluorouracil/cisplatin-based chemotherapy concurrently and were divided into high-dose (≥59.4 Gy, n = 44) and standard-dose (<59.4 Gy, n = 35) groups. Results: The median follow-up was 35 months for surviving patients. The high-dose group had significantly better 3-year local (90.0{\%} vs 60.4{\%}, P =.001) and locoregional (70.4{\%} vs 45.3{\%}, P =.04) control. Progression-free (45.4{\%} vs 37.5{\%}, P =.32) and overall (58.4{\%} vs 49.1{\%}, P =.69) survival rates were not different. High-dose radiation was an independent prognostic factor for locoregional control (P =.04). No differences in late toxicities (esophageal stenosis or tracheoesophageal fistula) were observed. Conclusion: High-dose radiation for CCE improves local and locoregional control, without increasing severe toxicities.",
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High-dose versus standard-dose radiation therapy for cervical esophageal cancer : Retrospective single-institution study. / Kim, Tae Hyung; Lee, Ik Jae; Kim, Ji Hyun; Lee, Chang Geol; Lee, Yongchan; Kim, Jun Won.

In: Head and Neck, Vol. 41, No. 1, 01.01.2019, p. 146-153.

Research output: Contribution to journalArticle

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