High-grade hydronephrosis predicts poor outcomes after radical cystectomy in patients with bladder cancer

Dong Suk Kim, Kang Su Cho, Young Hoon Lee, Namhoon Cho, Young Taek Oh, Sung Joon Hong

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We examined whether the presence and severity of preoperative hydronephrosis have prognostic significance in patients who underwent radical cystectomy for transitional cell carcinoma of the bladder. The medical records of 457 patients who underwent radical cystectomy for bladder cancer between 1986 and 2005 were retrospectively reviewed. Following the Society for Fetal Urology grading system, patients were divided into low-, and high-grade hydronephrosis groups. Clinicopathologic factors associated with preoperative hydronephrosis and survival were evaluated. Of a total of 406 patients, unilateral hydronephrosis was found in 74 (18.2%), bilateral hydronephrosis in 11 (2.7%), and no hydronephoris in 321 (79.1%). Low-grade hydronephrosis was found in 57 (12.2%) patients and high-grade hydronephrosis in 28 (6%). Preoperative hydronephrosis was related to higher pT stage and lymph node invasion. In univariate analysis, the presence of hydronephrosis, hydronephro-sis grade, age, pT and pN stage, tumor grade, surgical margin, number of retrieved nodes, carcinoma in situ, and lymphovascular invasion were significant prognostic factors for cancer-specific survival. In multivariate analysis, bilateral hydronephrosis and high-grade hydronephrosis remained significant predictors for decreased survival. The presence of preoperative hydronephrosis, and high-grade hydronephrosis are significant prognostic factors in patients with bladder cancer after radical cystectomy.

Original languageEnglish
Pages (from-to)369-373
Number of pages5
JournalJournal of Korean medical science
Volume25
Issue number3
DOIs
Publication statusPublished - 2010 Mar 1

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Hydronephrosis
Cystectomy
Urinary Bladder Neoplasms
Survival
Transitional Cell Carcinoma
Carcinoma in Situ
Urology
Medical Records
Neoplasms
Urinary Bladder
Multivariate Analysis
Lymph Nodes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kim, Dong Suk ; Cho, Kang Su ; Lee, Young Hoon ; Cho, Namhoon ; Oh, Young Taek ; Hong, Sung Joon. / High-grade hydronephrosis predicts poor outcomes after radical cystectomy in patients with bladder cancer. In: Journal of Korean medical science. 2010 ; Vol. 25, No. 3. pp. 369-373.
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High-grade hydronephrosis predicts poor outcomes after radical cystectomy in patients with bladder cancer. / Kim, Dong Suk; Cho, Kang Su; Lee, Young Hoon; Cho, Namhoon; Oh, Young Taek; Hong, Sung Joon.

In: Journal of Korean medical science, Vol. 25, No. 3, 01.03.2010, p. 369-373.

Research output: Contribution to journalArticle

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