High-grade squamous intraepithelial lesion arising adjacent to vulvar lymphangioma circumscriptum: A tertiary institutional experience

Go Eun Bae, Gun Yoon, Yong Jung Song, Hyun Soo Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Lymphangioma circumscriptum of the vulva occurs in patients who have undergone radical hysterectomy, lymph node dissection, or radiation therapy for management of advanced uterine cancer. Since vulvar lymphangioma circumscriptum typically presents as multiple, grossly verrucous vesicles of various sizes, it may be impossible to clinically distinguish vulvar lymphangioma circumscriptum from other vulvoperineal cutaneous diseases. In the present study, 16 (1.6%) out of the 1,024 vulvar biopsy or excision specimens were diagnosed as lymphangioma circumscriptum. In two (12.5%) out of the 16 cases, unusual histopathological findings were observed. Both patients had previously undergone radical hysterectomy with lymph node dissection and postoperative radiation therapy or concurrent chemoradiation therapy for advanced cervical cancer. Microscopic examination revealed high-grade squamous intraepithelial lesions, which were located immediately adjacent to the normal squamous epithelium covering the dilated subepithelial lymphatic vessels. Further, human papillomavirus genotyping confirmed that both patients were infected with high-risk human papillomavirus. High-grade squamous intraepithelial lesion cannot be grossly distinguished from vulvar lymphangioma circumscriptum because the multiple, verrucous vesicles that constitute the characteristic gross appearance of vulvar lymphangioma circumscriptum hinder its distinction. In this regard, our cases of high-grade squamous intraepithelial lesion, located adjacent to vulvar lymphangioma circumscriptum, support the notion that active surgical excision is necessary for the treatment of vulvar lymphangioma circumscriptum.

Original languageEnglish
Pages (from-to)48120-48129
Number of pages10
JournalOncotarget
Volume7
Issue number30
DOIs
Publication statusPublished - 2016 Jan 1

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Lymphangioma
Lymph Node Excision
Hysterectomy
Radiotherapy
Uterine Neoplasms
Lymphatic Vessels
Vulva
Squamous Intraepithelial Lesions of the Cervix
Skin Diseases
Uterine Cervical Neoplasms
Epithelium
Biopsy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

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title = "High-grade squamous intraepithelial lesion arising adjacent to vulvar lymphangioma circumscriptum: A tertiary institutional experience",
abstract = "Lymphangioma circumscriptum of the vulva occurs in patients who have undergone radical hysterectomy, lymph node dissection, or radiation therapy for management of advanced uterine cancer. Since vulvar lymphangioma circumscriptum typically presents as multiple, grossly verrucous vesicles of various sizes, it may be impossible to clinically distinguish vulvar lymphangioma circumscriptum from other vulvoperineal cutaneous diseases. In the present study, 16 (1.6{\%}) out of the 1,024 vulvar biopsy or excision specimens were diagnosed as lymphangioma circumscriptum. In two (12.5{\%}) out of the 16 cases, unusual histopathological findings were observed. Both patients had previously undergone radical hysterectomy with lymph node dissection and postoperative radiation therapy or concurrent chemoradiation therapy for advanced cervical cancer. Microscopic examination revealed high-grade squamous intraepithelial lesions, which were located immediately adjacent to the normal squamous epithelium covering the dilated subepithelial lymphatic vessels. Further, human papillomavirus genotyping confirmed that both patients were infected with high-risk human papillomavirus. High-grade squamous intraepithelial lesion cannot be grossly distinguished from vulvar lymphangioma circumscriptum because the multiple, verrucous vesicles that constitute the characteristic gross appearance of vulvar lymphangioma circumscriptum hinder its distinction. In this regard, our cases of high-grade squamous intraepithelial lesion, located adjacent to vulvar lymphangioma circumscriptum, support the notion that active surgical excision is necessary for the treatment of vulvar lymphangioma circumscriptum.",
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High-grade squamous intraepithelial lesion arising adjacent to vulvar lymphangioma circumscriptum : A tertiary institutional experience. / Bae, Go Eun; Yoon, Gun; Song, Yong Jung; Kim, Hyun Soo.

In: Oncotarget, Vol. 7, No. 30, 01.01.2016, p. 48120-48129.

Research output: Contribution to journalArticle

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