High-intensity focused US: A potential new treatment for GI bleeding

Joo Ha Hwang, Shahram Vaezy, Roy W. Martin, Mee Yon Cho, Misty L. Noble, Lawrence A. Crum, Michael B. Kimmey

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Abstract

Background: High-intensity focused US has been shown to achieve hemostasis in lacerated large veins and arteries. High-intensity focused US was studied as a potential endoscopic treatment for GI bleeding. Methods: A segment of the auricular vein of the rabbit was lacerated longitudinally and then treated with a high-intensity focused US transducer driven at 3.9 MHz (focal intensity of 750 W/cm2) in 15 animals until hemostasis was achieved. Sham treatment was delivered to 3 vessels. Rabbits were euthanized on days 0, 2, 7, 14, and 28 to allow for histologic evaluation of the response to treatment. Results: Hemostasis was achieved in all treated vessels and in none of the sham treatments. Mean treatment time was 13 seconds. Histology initially demonstrated acute thermal injury with subsequent thrombus formation and chronic inflammation leading to replacement of the vessel by fibrous scar tissue. Conclusions: High-intensity focused US causes hemostasis in acutely bleeding veins and results in occlusion of treated vessel with subsequent granulation tissue formation.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalGastrointestinal Endoscopy
Volume58
Issue number1
DOIs
Publication statusPublished - 2003 Jul

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All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Hwang, J. H., Vaezy, S., Martin, R. W., Cho, M. Y., Noble, M. L., Crum, L. A., & Kimmey, M. B. (2003). High-intensity focused US: A potential new treatment for GI bleeding. Gastrointestinal Endoscopy, 58(1), 111-115. https://doi.org/10.1067/mge.2003.322