High-intensity focused US

A potential new treatment for GI bleeding

Joo Ha Hwang, Shahram Vaezy, Roy W. Martin, Meeyon Cho, Misty L. Noble, Lawrence A. Crum, Michael B. Kimmey

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: High-intensity focused US has been shown to achieve hemostasis in lacerated large veins and arteries. High-intensity focused US was studied as a potential endoscopic treatment for GI bleeding. Methods: A segment of the auricular vein of the rabbit was lacerated longitudinally and then treated with a high-intensity focused US transducer driven at 3.9 MHz (focal intensity of 750 W/cm2) in 15 animals until hemostasis was achieved. Sham treatment was delivered to 3 vessels. Rabbits were euthanized on days 0, 2, 7, 14, and 28 to allow for histologic evaluation of the response to treatment. Results: Hemostasis was achieved in all treated vessels and in none of the sham treatments. Mean treatment time was 13 seconds. Histology initially demonstrated acute thermal injury with subsequent thrombus formation and chronic inflammation leading to replacement of the vessel by fibrous scar tissue. Conclusions: High-intensity focused US causes hemostasis in acutely bleeding veins and results in occlusion of treated vessel with subsequent granulation tissue formation.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalGastrointestinal Endoscopy
Volume58
Issue number1
DOIs
Publication statusPublished - 2003 Jan 1

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Hemostasis
Hemorrhage
Veins
Placebos
Rabbits
Granulation Tissue
Therapeutics
Transducers
Cicatrix
Histology
Thrombosis
Arteries
Hot Temperature
Inflammation
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Hwang, J. H., Vaezy, S., Martin, R. W., Cho, M., Noble, M. L., Crum, L. A., & Kimmey, M. B. (2003). High-intensity focused US: A potential new treatment for GI bleeding. Gastrointestinal Endoscopy, 58(1), 111-115. https://doi.org/10.1067/mge.2003.322
Hwang, Joo Ha ; Vaezy, Shahram ; Martin, Roy W. ; Cho, Meeyon ; Noble, Misty L. ; Crum, Lawrence A. ; Kimmey, Michael B. / High-intensity focused US : A potential new treatment for GI bleeding. In: Gastrointestinal Endoscopy. 2003 ; Vol. 58, No. 1. pp. 111-115.
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Hwang, JH, Vaezy, S, Martin, RW, Cho, M, Noble, ML, Crum, LA & Kimmey, MB 2003, 'High-intensity focused US: A potential new treatment for GI bleeding', Gastrointestinal Endoscopy, vol. 58, no. 1, pp. 111-115. https://doi.org/10.1067/mge.2003.322

High-intensity focused US : A potential new treatment for GI bleeding. / Hwang, Joo Ha; Vaezy, Shahram; Martin, Roy W.; Cho, Meeyon; Noble, Misty L.; Crum, Lawrence A.; Kimmey, Michael B.

In: Gastrointestinal Endoscopy, Vol. 58, No. 1, 01.01.2003, p. 111-115.

Research output: Contribution to journalArticle

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AU - Hwang, Joo Ha

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AU - Martin, Roy W.

AU - Cho, Meeyon

AU - Noble, Misty L.

AU - Crum, Lawrence A.

AU - Kimmey, Michael B.

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N2 - Background: High-intensity focused US has been shown to achieve hemostasis in lacerated large veins and arteries. High-intensity focused US was studied as a potential endoscopic treatment for GI bleeding. Methods: A segment of the auricular vein of the rabbit was lacerated longitudinally and then treated with a high-intensity focused US transducer driven at 3.9 MHz (focal intensity of 750 W/cm2) in 15 animals until hemostasis was achieved. Sham treatment was delivered to 3 vessels. Rabbits were euthanized on days 0, 2, 7, 14, and 28 to allow for histologic evaluation of the response to treatment. Results: Hemostasis was achieved in all treated vessels and in none of the sham treatments. Mean treatment time was 13 seconds. Histology initially demonstrated acute thermal injury with subsequent thrombus formation and chronic inflammation leading to replacement of the vessel by fibrous scar tissue. Conclusions: High-intensity focused US causes hemostasis in acutely bleeding veins and results in occlusion of treated vessel with subsequent granulation tissue formation.

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