High left atrial pressures are associated with advanced electroanatomical remodeling of left atrium and independent predictors for clinical recurrence of atrial fibrillation after catheter ablation

Junbeom Park, Boyoung Joung, Jae Sun Uhm, Chi Young Shim, Chun Hwang, Moon Hyoung Lee, Hui Nam Pak

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53 Citations (Scopus)

Abstract

Background The clinical significance of left atrial pressure (LAP) has not yet been clearly elucidated in patients with atrial fibrillation (AF). Objective To explore the effects of elevated LAP on pathophysiology and clinical outcome after radiofrequency catheter ablation in patients with AF. Methods We measured LAP during both sinus rhythm (SR) and AF in 454 patients 348 (76.7%) men; mean age 58 ± 11 years; 326(71.8%) paroxysmal AF) who underwent radiofrequency catheter ablation and compared LAP at v wave (LAPpeak) and LAP at y descent (LAPnadir) by using imaging (echocardiography and computed tomography), electrophysiologic mapping (NavX), and clinical data. In 280 (61.7%) patients, pulmonary vein (PV) diastolic flow velocity was measured during SR by transesophageal echocardiography. Results Patients with LAP peak(SR) ≥19 mm Hg had greater left atrial (LA) dimension (P <.001), LA volume index (P =.003), and E/Em (mitral annular septal area [peak diastolic velocity]; P =.001) but reduced LA voltage (P <.001) and mitral annular septal area (peak systolic velocity; P =.006) compared with patients with LAPpeak(SR) <19 mm Hg. High LAPpeak(SR) was independently associated with anterior LA volume (linear regression coefficient [B] = 0.381; 95% confidence interval [CI] 0.169-0.593; P <.001) and low LA voltage (B = -0.022; 95% CI -0.030 to -0.013; P <.001). PV diastolic flow velocity (B = 0.161; 95% CI 0.083-0.239; P <.001) and E/Em (B = 0.430; 95% CI 0.096-0.763; P =.012) were independent, noninvasive parameters associated with high LApeak(SR). During 13.1 ± 6.0 months of follow-up, high LAPpeak(SR) was an independent predictor for clinical recurrence of AF (hazard ratio 1.887; 95% CI 1.063-3.350; P =.028). Conclusion Elevated LAP was closely associated with electroanatomical remodeling of the LA and was an independent predictor for recurrence after AF ablation. PV diastolic flow velocity and E/Em can be used as a noninvasive parameter predicting high LAPpeak(SR) in patients with AF.

Original languageEnglish
Pages (from-to)953-960
Number of pages8
JournalHeart Rhythm
Volume11
Issue number6
DOIs
Publication statusPublished - 2014 Jun

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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