Background The clinical significance of left atrial pressure (LAP) has not yet been clearly elucidated in patients with atrial fibrillation (AF). Objective To explore the effects of elevated LAP on pathophysiology and clinical outcome after radiofrequency catheter ablation in patients with AF. Methods We measured LAP during both sinus rhythm (SR) and AF in 454 patients 348 (76.7%) men; mean age 58 ± 11 years; 326(71.8%) paroxysmal AF) who underwent radiofrequency catheter ablation and compared LAP at v wave (LAPpeak) and LAP at y descent (LAPnadir) by using imaging (echocardiography and computed tomography), electrophysiologic mapping (NavX), and clinical data. In 280 (61.7%) patients, pulmonary vein (PV) diastolic flow velocity was measured during SR by transesophageal echocardiography. Results Patients with LAP peak(SR) ≥19 mm Hg had greater left atrial (LA) dimension (P <.001), LA volume index (P =.003), and E/Em (mitral annular septal area [peak diastolic velocity]; P =.001) but reduced LA voltage (P <.001) and mitral annular septal area (peak systolic velocity; P =.006) compared with patients with LAPpeak(SR) <19 mm Hg. High LAPpeak(SR) was independently associated with anterior LA volume (linear regression coefficient [B] = 0.381; 95% confidence interval [CI] 0.169-0.593; P <.001) and low LA voltage (B = -0.022; 95% CI -0.030 to -0.013; P <.001). PV diastolic flow velocity (B = 0.161; 95% CI 0.083-0.239; P <.001) and E/Em (B = 0.430; 95% CI 0.096-0.763; P =.012) were independent, noninvasive parameters associated with high LApeak(SR). During 13.1 ± 6.0 months of follow-up, high LAPpeak(SR) was an independent predictor for clinical recurrence of AF (hazard ratio 1.887; 95% CI 1.063-3.350; P =.028). Conclusion Elevated LAP was closely associated with electroanatomical remodeling of the LA and was an independent predictor for recurrence after AF ablation. PV diastolic flow velocity and E/Em can be used as a noninvasive parameter predicting high LAPpeak(SR) in patients with AF.
Bibliographical noteFunding Information:
This work was supported by a grant ( 2012027176 ) from the Basic Science Research Program run by the National Research Foundation of Korea , which is funded by the Ministry of Science, ICT and Future Planning.
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
- Physiology (medical)