High level of preoperative carbohydrate antigen 19-9 is a poor survival predictor in gastric cancer

A. Ra Choi, Jun Chul Park, Jie-Hyun Kim, Sung Kwan Shin, SangKil Lee, Yongchan Lee, Jae Bock Chung

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aim: To assess the clinical significance and the prognostic value of preoperative serum carbohydrate antigen 19-9 (CA 19-9) level in gastric cancer.Methods: Between January 2005 and December 2006, 1960 patients underwent surgery for histologically confirmed gastric cancer. Of these, 163 patients had elevated serum levels of CA 19-9 preoperatively, and 1628 patients had normal serum levels of CA 19-9 preoperatively. For this study, 325 patients were selected from the group of 1628 patients by age, sex, and cancer stage to serve as controls. Statistically significant differences in survival rates were calculated using the log-rank test. A P value less than 0.05 was considered statistically significant and was determined using SAS software. Results: The baseline characteristics showed some differences between the two groups with regard to histology. Overall survival (OS) in the elevated and nonelevated group was 37.90 and 68.67 mo, respectively (P < 0.001). N stage (P = 0.001) was a significant predictor of disease-free survival by multivariate analysis. Also, N stage (P < 0.001), and the presence of peritoneal metastasis (P < 0.001) remained independent factors in predicting OS by multivariate analysis. Additionally, preoperative serum CA 19-9 levels were significantly associated with OS in univariate (P = 0.009) and multivariate (P = 0.021) analyses. Conclution: Serum CA 19-9 can be considered an independent prognostic factor in predicting OS in patients anticipating surgery for gastric cancer.

Original languageEnglish
Pages (from-to)5302-5308
Number of pages7
JournalWorld Journal of Gastroenterology
Volume19
Issue number32
DOIs
Publication statusPublished - 2013 Aug 28

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Stomach Neoplasms
Carbohydrates
Antigens
Survival
Serum
Survival Analysis
Multivariate Analysis
Disease-Free Survival
Histology
Software
Survival Rate
Neoplasm Metastasis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

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title = "High level of preoperative carbohydrate antigen 19-9 is a poor survival predictor in gastric cancer",
abstract = "Aim: To assess the clinical significance and the prognostic value of preoperative serum carbohydrate antigen 19-9 (CA 19-9) level in gastric cancer.Methods: Between January 2005 and December 2006, 1960 patients underwent surgery for histologically confirmed gastric cancer. Of these, 163 patients had elevated serum levels of CA 19-9 preoperatively, and 1628 patients had normal serum levels of CA 19-9 preoperatively. For this study, 325 patients were selected from the group of 1628 patients by age, sex, and cancer stage to serve as controls. Statistically significant differences in survival rates were calculated using the log-rank test. A P value less than 0.05 was considered statistically significant and was determined using SAS software. Results: The baseline characteristics showed some differences between the two groups with regard to histology. Overall survival (OS) in the elevated and nonelevated group was 37.90 and 68.67 mo, respectively (P < 0.001). N stage (P = 0.001) was a significant predictor of disease-free survival by multivariate analysis. Also, N stage (P < 0.001), and the presence of peritoneal metastasis (P < 0.001) remained independent factors in predicting OS by multivariate analysis. Additionally, preoperative serum CA 19-9 levels were significantly associated with OS in univariate (P = 0.009) and multivariate (P = 0.021) analyses. Conclution: Serum CA 19-9 can be considered an independent prognostic factor in predicting OS in patients anticipating surgery for gastric cancer.",
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High level of preoperative carbohydrate antigen 19-9 is a poor survival predictor in gastric cancer. / Ra Choi, A.; Park, Jun Chul; Kim, Jie-Hyun; Shin, Sung Kwan; Lee, SangKil; Lee, Yongchan; Chung, Jae Bock.

In: World Journal of Gastroenterology, Vol. 19, No. 32, 28.08.2013, p. 5302-5308.

Research output: Contribution to journalArticle

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AU - Ra Choi, A.

AU - Park, Jun Chul

AU - Kim, Jie-Hyun

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N2 - Aim: To assess the clinical significance and the prognostic value of preoperative serum carbohydrate antigen 19-9 (CA 19-9) level in gastric cancer.Methods: Between January 2005 and December 2006, 1960 patients underwent surgery for histologically confirmed gastric cancer. Of these, 163 patients had elevated serum levels of CA 19-9 preoperatively, and 1628 patients had normal serum levels of CA 19-9 preoperatively. For this study, 325 patients were selected from the group of 1628 patients by age, sex, and cancer stage to serve as controls. Statistically significant differences in survival rates were calculated using the log-rank test. A P value less than 0.05 was considered statistically significant and was determined using SAS software. Results: The baseline characteristics showed some differences between the two groups with regard to histology. Overall survival (OS) in the elevated and nonelevated group was 37.90 and 68.67 mo, respectively (P < 0.001). N stage (P = 0.001) was a significant predictor of disease-free survival by multivariate analysis. Also, N stage (P < 0.001), and the presence of peritoneal metastasis (P < 0.001) remained independent factors in predicting OS by multivariate analysis. Additionally, preoperative serum CA 19-9 levels were significantly associated with OS in univariate (P = 0.009) and multivariate (P = 0.021) analyses. Conclution: Serum CA 19-9 can be considered an independent prognostic factor in predicting OS in patients anticipating surgery for gastric cancer.

AB - Aim: To assess the clinical significance and the prognostic value of preoperative serum carbohydrate antigen 19-9 (CA 19-9) level in gastric cancer.Methods: Between January 2005 and December 2006, 1960 patients underwent surgery for histologically confirmed gastric cancer. Of these, 163 patients had elevated serum levels of CA 19-9 preoperatively, and 1628 patients had normal serum levels of CA 19-9 preoperatively. For this study, 325 patients were selected from the group of 1628 patients by age, sex, and cancer stage to serve as controls. Statistically significant differences in survival rates were calculated using the log-rank test. A P value less than 0.05 was considered statistically significant and was determined using SAS software. Results: The baseline characteristics showed some differences between the two groups with regard to histology. Overall survival (OS) in the elevated and nonelevated group was 37.90 and 68.67 mo, respectively (P < 0.001). N stage (P = 0.001) was a significant predictor of disease-free survival by multivariate analysis. Also, N stage (P < 0.001), and the presence of peritoneal metastasis (P < 0.001) remained independent factors in predicting OS by multivariate analysis. Additionally, preoperative serum CA 19-9 levels were significantly associated with OS in univariate (P = 0.009) and multivariate (P = 0.021) analyses. Conclution: Serum CA 19-9 can be considered an independent prognostic factor in predicting OS in patients anticipating surgery for gastric cancer.

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