High microsatellite instability predicts good prognosis in intestinal-type gastric cancers

Hyunki Kim, Ji Yeong An, Sung Hoon Noh, Sung Kwan Shin, Yongchan Lee, Hoguen Kim

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Background and Aim: A subset of gastric cancers showed high microsatellite instability (MSI-H). The reported clinicopathological features of MSI-H gastric cancers are heterogeneous, and specific factors associated with prognosis have not been identified. Methods: We analyzed the clinicopathological characteristics and prognostic factors in a large series (161 cases) of MSI-H gastric cancers, and compared the results to 315 cases of microsatellite-stable or low microsatellite-instable gastric cancers. Results: The frequency of MSI-H gastric cancers was 9% (161/1786). MSI-H gastric cancers have distinct clinicopathological features, including female sex, older age, antral location, well-to-moderate differentiation, intestinal-type Lauren classification, expanding-type Ming classification, a non-signet-ring cell component, the presence of a mucinous component, a moderate-to-severe lymphoid stromal reaction, and a lower tumor stage. The MSI-H phenotype was associated with better prognosis (P=0.044), and male sex (P=0.035, hazard ratios [HR]: 0.23), intestinal-/mixed-type Lauren classification (P<0.001, HR: 0.09) and lower tumor stages (1 and 2, P=0.001, HR: 0.08) were independently-favorable prognostic factors. Conclusions: With unique clinicopathological features, intestinal-type MSI-H gastric cancers are associated with good prognosis and can be classified as a different subset of gastric cancers.

Original languageEnglish
Pages (from-to)585-592
Number of pages8
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume26
Issue number3
DOIs
Publication statusPublished - 2011 Jan 1

Fingerprint

Intestinal Neoplasms
Microsatellite Instability
Stomach Neoplasms
Microsatellite Repeats
Cellular Structures
N-methylsuccinimide
Neoplasms
Phenotype

All Science Journal Classification (ASJC) codes

  • Gastroenterology
  • Hepatology

Cite this

Kim, Hyunki ; An, Ji Yeong ; Noh, Sung Hoon ; Shin, Sung Kwan ; Lee, Yongchan ; Kim, Hoguen. / High microsatellite instability predicts good prognosis in intestinal-type gastric cancers. In: Journal of Gastroenterology and Hepatology (Australia). 2011 ; Vol. 26, No. 3. pp. 585-592.
@article{afa9da73bb0b4ef2ab4b2ca7489f4c4e,
title = "High microsatellite instability predicts good prognosis in intestinal-type gastric cancers",
abstract = "Background and Aim: A subset of gastric cancers showed high microsatellite instability (MSI-H). The reported clinicopathological features of MSI-H gastric cancers are heterogeneous, and specific factors associated with prognosis have not been identified. Methods: We analyzed the clinicopathological characteristics and prognostic factors in a large series (161 cases) of MSI-H gastric cancers, and compared the results to 315 cases of microsatellite-stable or low microsatellite-instable gastric cancers. Results: The frequency of MSI-H gastric cancers was 9{\%} (161/1786). MSI-H gastric cancers have distinct clinicopathological features, including female sex, older age, antral location, well-to-moderate differentiation, intestinal-type Lauren classification, expanding-type Ming classification, a non-signet-ring cell component, the presence of a mucinous component, a moderate-to-severe lymphoid stromal reaction, and a lower tumor stage. The MSI-H phenotype was associated with better prognosis (P=0.044), and male sex (P=0.035, hazard ratios [HR]: 0.23), intestinal-/mixed-type Lauren classification (P<0.001, HR: 0.09) and lower tumor stages (1 and 2, P=0.001, HR: 0.08) were independently-favorable prognostic factors. Conclusions: With unique clinicopathological features, intestinal-type MSI-H gastric cancers are associated with good prognosis and can be classified as a different subset of gastric cancers.",
author = "Hyunki Kim and An, {Ji Yeong} and Noh, {Sung Hoon} and Shin, {Sung Kwan} and Yongchan Lee and Hoguen Kim",
year = "2011",
month = "1",
day = "1",
doi = "10.1111/j.1440-1746.2010.06487.x",
language = "English",
volume = "26",
pages = "585--592",
journal = "Journal of Gastroenterology and Hepatology (Australia)",
issn = "0815-9319",
publisher = "Wiley-Blackwell",
number = "3",

}

High microsatellite instability predicts good prognosis in intestinal-type gastric cancers. / Kim, Hyunki; An, Ji Yeong; Noh, Sung Hoon; Shin, Sung Kwan; Lee, Yongchan; Kim, Hoguen.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 26, No. 3, 01.01.2011, p. 585-592.

Research output: Contribution to journalArticle

TY - JOUR

T1 - High microsatellite instability predicts good prognosis in intestinal-type gastric cancers

AU - Kim, Hyunki

AU - An, Ji Yeong

AU - Noh, Sung Hoon

AU - Shin, Sung Kwan

AU - Lee, Yongchan

AU - Kim, Hoguen

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Background and Aim: A subset of gastric cancers showed high microsatellite instability (MSI-H). The reported clinicopathological features of MSI-H gastric cancers are heterogeneous, and specific factors associated with prognosis have not been identified. Methods: We analyzed the clinicopathological characteristics and prognostic factors in a large series (161 cases) of MSI-H gastric cancers, and compared the results to 315 cases of microsatellite-stable or low microsatellite-instable gastric cancers. Results: The frequency of MSI-H gastric cancers was 9% (161/1786). MSI-H gastric cancers have distinct clinicopathological features, including female sex, older age, antral location, well-to-moderate differentiation, intestinal-type Lauren classification, expanding-type Ming classification, a non-signet-ring cell component, the presence of a mucinous component, a moderate-to-severe lymphoid stromal reaction, and a lower tumor stage. The MSI-H phenotype was associated with better prognosis (P=0.044), and male sex (P=0.035, hazard ratios [HR]: 0.23), intestinal-/mixed-type Lauren classification (P<0.001, HR: 0.09) and lower tumor stages (1 and 2, P=0.001, HR: 0.08) were independently-favorable prognostic factors. Conclusions: With unique clinicopathological features, intestinal-type MSI-H gastric cancers are associated with good prognosis and can be classified as a different subset of gastric cancers.

AB - Background and Aim: A subset of gastric cancers showed high microsatellite instability (MSI-H). The reported clinicopathological features of MSI-H gastric cancers are heterogeneous, and specific factors associated with prognosis have not been identified. Methods: We analyzed the clinicopathological characteristics and prognostic factors in a large series (161 cases) of MSI-H gastric cancers, and compared the results to 315 cases of microsatellite-stable or low microsatellite-instable gastric cancers. Results: The frequency of MSI-H gastric cancers was 9% (161/1786). MSI-H gastric cancers have distinct clinicopathological features, including female sex, older age, antral location, well-to-moderate differentiation, intestinal-type Lauren classification, expanding-type Ming classification, a non-signet-ring cell component, the presence of a mucinous component, a moderate-to-severe lymphoid stromal reaction, and a lower tumor stage. The MSI-H phenotype was associated with better prognosis (P=0.044), and male sex (P=0.035, hazard ratios [HR]: 0.23), intestinal-/mixed-type Lauren classification (P<0.001, HR: 0.09) and lower tumor stages (1 and 2, P=0.001, HR: 0.08) were independently-favorable prognostic factors. Conclusions: With unique clinicopathological features, intestinal-type MSI-H gastric cancers are associated with good prognosis and can be classified as a different subset of gastric cancers.

UR - http://www.scopus.com/inward/record.url?scp=79951593439&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951593439&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1746.2010.06487.x

DO - 10.1111/j.1440-1746.2010.06487.x

M3 - Article

VL - 26

SP - 585

EP - 592

JO - Journal of Gastroenterology and Hepatology (Australia)

JF - Journal of Gastroenterology and Hepatology (Australia)

SN - 0815-9319

IS - 3

ER -