High-order synchronization of hair cell bundles

Michael Levy, Adrian Molzon, Jae Hyun Lee, Ji Wook Kim, Jinwoo Cheon, Dolores Bozovic

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Auditory and vestibular hair cell bundles exhibit active mechanical oscillations at natural frequencies that are typically lower than the detection range of the corresponding end organs. We explore how these noisy nonlinear oscillators mode-lock to frequencies higher than their internal clocks. A nanomagnetic technique is used to stimulate the bundles without an imposed mechanical load. The evoked response shows regimes of high-order mode-locking. Exploring a broad range of stimulus frequencies and intensities, we observe regions of high-order synchronization, analogous to Arnold Tongues in dynamical systems literature. Significant areas of overlap occur between synchronization regimes, with the bundle intermittently flickering between different winding numbers. We demonstrate how an ensemble of these noisy spontaneous oscillators could be entrained to efficiently detect signals significantly above the characteristic frequencies of the individual cells.

Original languageEnglish
Article number39116
JournalScientific reports
Publication statusPublished - 2016 Dec 15

Bibliographical note

Funding Information:
This research was supported by AFOSR grant FA9550-12-1-0447 to D.B. and J.C., NIH grant R21 DC015035 to D.B., Institute for Basic Science (IBS-R026-D1) to J.C., and the Korea Healthcare Technology R&D Project (HI08C2149) to J.C.

Publisher Copyright:
© The Author(s) 2016.

All Science Journal Classification (ASJC) codes

  • General


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