Abstract
Auditory and vestibular hair cell bundles exhibit active mechanical oscillations at natural frequencies that are typically lower than the detection range of the corresponding end organs. We explore how these noisy nonlinear oscillators mode-lock to frequencies higher than their internal clocks. A nanomagnetic technique is used to stimulate the bundles without an imposed mechanical load. The evoked response shows regimes of high-order mode-locking. Exploring a broad range of stimulus frequencies and intensities, we observe regions of high-order synchronization, analogous to Arnold Tongues in dynamical systems literature. Significant areas of overlap occur between synchronization regimes, with the bundle intermittently flickering between different winding numbers. We demonstrate how an ensemble of these noisy spontaneous oscillators could be entrained to efficiently detect signals significantly above the characteristic frequencies of the individual cells.
| Original language | English |
|---|---|
| Article number | 39116 |
| Journal | Scientific reports |
| Volume | 6 |
| DOIs | |
| Publication status | Published - 2016 Dec 15 |
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All Science Journal Classification (ASJC) codes
- General
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High-order synchronization of hair cell bundles. / Levy, Michael; Molzon, Adrian; Lee, Jae Hyun; Kim, Ji Wook; Cheon, Jinwoo; Bozovic, Dolores.
In: Scientific reports, Vol. 6, 39116, 15.12.2016.Research output: Contribution to journal › Article
TY - JOUR
T1 - High-order synchronization of hair cell bundles
AU - Levy, Michael
AU - Molzon, Adrian
AU - Lee, Jae Hyun
AU - Kim, Ji Wook
AU - Cheon, Jinwoo
AU - Bozovic, Dolores
PY - 2016/12/15
Y1 - 2016/12/15
N2 - Auditory and vestibular hair cell bundles exhibit active mechanical oscillations at natural frequencies that are typically lower than the detection range of the corresponding end organs. We explore how these noisy nonlinear oscillators mode-lock to frequencies higher than their internal clocks. A nanomagnetic technique is used to stimulate the bundles without an imposed mechanical load. The evoked response shows regimes of high-order mode-locking. Exploring a broad range of stimulus frequencies and intensities, we observe regions of high-order synchronization, analogous to Arnold Tongues in dynamical systems literature. Significant areas of overlap occur between synchronization regimes, with the bundle intermittently flickering between different winding numbers. We demonstrate how an ensemble of these noisy spontaneous oscillators could be entrained to efficiently detect signals significantly above the characteristic frequencies of the individual cells.
AB - Auditory and vestibular hair cell bundles exhibit active mechanical oscillations at natural frequencies that are typically lower than the detection range of the corresponding end organs. We explore how these noisy nonlinear oscillators mode-lock to frequencies higher than their internal clocks. A nanomagnetic technique is used to stimulate the bundles without an imposed mechanical load. The evoked response shows regimes of high-order mode-locking. Exploring a broad range of stimulus frequencies and intensities, we observe regions of high-order synchronization, analogous to Arnold Tongues in dynamical systems literature. Significant areas of overlap occur between synchronization regimes, with the bundle intermittently flickering between different winding numbers. We demonstrate how an ensemble of these noisy spontaneous oscillators could be entrained to efficiently detect signals significantly above the characteristic frequencies of the individual cells.
UR - http://www.scopus.com/inward/record.url?scp=85006085573&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006085573&partnerID=8YFLogxK
U2 - 10.1038/srep39116
DO - 10.1038/srep39116
M3 - Article
C2 - 27974743
AN - SCOPUS:85006085573
VL - 6
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 39116
ER -