High pre-transplant serum ferritin and busulfan-thiotepa conditioning regimen as risk factors for hepatic sinusoidal obstructive syndrome after autologous stem cell transplantation in patients with malignant lymphoma

Doh Yu Hwang, Soo Jeong Kim, June Won Cheong, Yundeok Kim, Ji Eun Jang, Jung Yeon Lee, Yoo Hong Min, Woo Ick Yang, Jinseok Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Few studies have evaluated the risk factors for hepatic sinusoidal obstructive syndrome (SOS) in patients with malignant lymphoma receiving autologous stem cell transplantation (ASCT). We retrospectively analyzed 132 malignant lymphoma patients who underwent ASCT. Intravenous busulfan-based conditioning regimens were used in 108 (81.8%) patients. The combination of heparin and ursodeoxycholic acid was used for prophylaxis of SOS. Hepatic SOS was developed in 10 (7.6%) patients at a median of 30 days post-ASCT. In nine (90.0%) patients, SOS was diagnosed after 20 days post-ASCT. Two patients developed severe SOS and eventually died from multiple organ failure. In multivariate analysis, the use of the busulfan-thiotepa conditioning regimen (p = 0.003) and a high pre-transplant serum ferritin level (≥ 950 ng/mL) (p = 0.003) were risk factors for hepatic SOS. The evaluation of pre-transplant serum ferritin may be helpful in determining the most appropriate conditioning regimen with a lower risk of SOS.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalLeukemia and Lymphoma
Volume57
Issue number1
DOIs
Publication statusPublished - 2016 Jan 2

Fingerprint

Thiotepa
Busulfan
Stem Cell Transplantation
Ferritins
Lymphoma
Transplants
Liver
Serum
Ursodeoxycholic Acid
Multiple Organ Failure
Heparin
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Hwang, Doh Yu ; Kim, Soo Jeong ; Cheong, June Won ; Kim, Yundeok ; Jang, Ji Eun ; Lee, Jung Yeon ; Min, Yoo Hong ; Yang, Woo Ick ; Kim, Jinseok. / High pre-transplant serum ferritin and busulfan-thiotepa conditioning regimen as risk factors for hepatic sinusoidal obstructive syndrome after autologous stem cell transplantation in patients with malignant lymphoma. In: Leukemia and Lymphoma. 2016 ; Vol. 57, No. 1. pp. 51-57.
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abstract = "Few studies have evaluated the risk factors for hepatic sinusoidal obstructive syndrome (SOS) in patients with malignant lymphoma receiving autologous stem cell transplantation (ASCT). We retrospectively analyzed 132 malignant lymphoma patients who underwent ASCT. Intravenous busulfan-based conditioning regimens were used in 108 (81.8{\%}) patients. The combination of heparin and ursodeoxycholic acid was used for prophylaxis of SOS. Hepatic SOS was developed in 10 (7.6{\%}) patients at a median of 30 days post-ASCT. In nine (90.0{\%}) patients, SOS was diagnosed after 20 days post-ASCT. Two patients developed severe SOS and eventually died from multiple organ failure. In multivariate analysis, the use of the busulfan-thiotepa conditioning regimen (p = 0.003) and a high pre-transplant serum ferritin level (≥ 950 ng/mL) (p = 0.003) were risk factors for hepatic SOS. The evaluation of pre-transplant serum ferritin may be helpful in determining the most appropriate conditioning regimen with a lower risk of SOS.",
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High pre-transplant serum ferritin and busulfan-thiotepa conditioning regimen as risk factors for hepatic sinusoidal obstructive syndrome after autologous stem cell transplantation in patients with malignant lymphoma. / Hwang, Doh Yu; Kim, Soo Jeong; Cheong, June Won; Kim, Yundeok; Jang, Ji Eun; Lee, Jung Yeon; Min, Yoo Hong; Yang, Woo Ick; Kim, Jinseok.

In: Leukemia and Lymphoma, Vol. 57, No. 1, 02.01.2016, p. 51-57.

Research output: Contribution to journalArticle

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AU - Kim, Soo Jeong

AU - Cheong, June Won

AU - Kim, Yundeok

AU - Jang, Ji Eun

AU - Lee, Jung Yeon

AU - Min, Yoo Hong

AU - Yang, Woo Ick

AU - Kim, Jinseok

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N2 - Few studies have evaluated the risk factors for hepatic sinusoidal obstructive syndrome (SOS) in patients with malignant lymphoma receiving autologous stem cell transplantation (ASCT). We retrospectively analyzed 132 malignant lymphoma patients who underwent ASCT. Intravenous busulfan-based conditioning regimens were used in 108 (81.8%) patients. The combination of heparin and ursodeoxycholic acid was used for prophylaxis of SOS. Hepatic SOS was developed in 10 (7.6%) patients at a median of 30 days post-ASCT. In nine (90.0%) patients, SOS was diagnosed after 20 days post-ASCT. Two patients developed severe SOS and eventually died from multiple organ failure. In multivariate analysis, the use of the busulfan-thiotepa conditioning regimen (p = 0.003) and a high pre-transplant serum ferritin level (≥ 950 ng/mL) (p = 0.003) were risk factors for hepatic SOS. The evaluation of pre-transplant serum ferritin may be helpful in determining the most appropriate conditioning regimen with a lower risk of SOS.

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