High Quality Bioreplication of Intricate Nanostructures from a Fragile Gecko Skin Surface with Bactericidal Properties

David William Green, Kenneth Ka Ho Lee, Jolanta Anna Watson, Hyun Yi Kim, Kyung Sik Yoon, Eun Jung Kim, Jong Min Lee, Gregory Shaun Watson, Han Sung Jung

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28 Citations (Scopus)

Abstract

The external epithelial surfaces of plants and animals are frequently carpeted with small micro-and nanostructures, which broadens their adaptive capabilities in challenging physical habitats. Hairs and other shaped protuberances manage with excessive water, light contaminants, predators or parasites in innovative ways. We are interested in transferring these intricate architectures onto biomedical devices and daily-life surfaces. Such a project requires a very rapid and accurate small-scale fabrication process not involving lithography. In this study, we describe a simple benchtop biotemplating method using shed gecko lizard skin that generates duplicates that closely replicate the small nanotipped hairs (spinules) that cover the original skin. Synthetic replication of the spinule arrays in popular biomaterials closely matched the natural spinules in length. More significantly, the shape, curvature and nanotips of the synthetic arrays are virtually identical to the natural ones. Despite some small differences, the synthetic gecko skin surface resisted wetting and bacterial contamination at the same level as natural shed skin templates. Such synthetic gecko skin surfaces are excellent platforms to test for bacterial control in clinical settings. We envision testing the biocidal properties of the well-matched templates for fungal spores and viral resistance in biomedicine as well as co/multi-cultures.

Original languageEnglish
Article number41023
JournalScientific reports
Volume7
DOIs
Publication statusPublished - 2017 Jan 25

All Science Journal Classification (ASJC) codes

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    Green, D. W., Lee, K. K. H., Watson, J. A., Kim, H. Y., Yoon, K. S., Kim, E. J., Lee, J. M., Watson, G. S., & Jung, H. S. (2017). High Quality Bioreplication of Intricate Nanostructures from a Fragile Gecko Skin Surface with Bactericidal Properties. Scientific reports, 7, [41023]. https://doi.org/10.1038/srep41023