Background Hemodynamic burden is thought to play a role in valvular atrial fibrillation (AF), but the detailed pathophysiology is unclear. We hypothesized that atrial natriuretic peptide (ANP) tissue levels and amyloid deposits in the left atrial appendage (LAA) were associated with the pre-operative hemodynamic status and post-operative rhythm outcome in patients undergoing a concomitant mitral valve and maze surgery. Methods We quantified the fibrosis, atrial amyloid deposits, ANP tissue levels, and multiple biomarker proteins (Western blot) in LAA tissues taken from 26 patients (53.8% male, 58.4 ± 9.7 years) who underwent concomitant maze and mitral valve surgery. The histologic and biochemical results were compared with the pre-operative pulmonary artery pressure (PAP) and post-operative rhythm outcome. Results The ANP tissue level was positively correlated with the atrial amyloid deposit areas (R = 0.880, p < 0.001), but not with the degree of fibrosis. The pre-operative systolic PAP negatively correlated with both the ANP tissue expression level (R = −0.467, p = 0.019) and atrial amyloid deposit area (R = −0.589, p = 0.008). The angiotensin II tissue expression level was significantly higher in tissues without ANP expression than in those with expression (p = 0.003). AF recurrence after the maze operation was significantly lower in patients without than in those with ANP expression (log rank p = 0.031, HR 3.779, 95% CI 1.163–12.277, p = 0.027). Conclusions A lower ANP atrial tissue expression and amyloid deposits were correlated with a high pre-operative hemodynamic loading, and those patients had a paradoxically lower AF recurrence after relief of the hemodynamic burden by concomitant maze and mitral valve surgery.
Bibliographical noteFunding Information:
This study was supported by a grant from the Korean Heart Rhythm Society ( KHRS2013-1 ) to Park J, from the Korea Health 21 R&D Project, Ministry of Health and Welfare ( A085136 ) to Pak HN, and the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (MSIP; 7-2013-0362 ) to Pak HN.
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine