High resolution mapping of the pulmonary vein and the vein of marshall during induced atrial fibrillation and atrial tachycardia in a canine model of pacing-induced congestive heart failure

Yuji Okuyama, Yasushi Miyauchi, Angela M. Park, Akira Hamabe, Shengmei Zhou, Hideki Hayashi, Mizuho Miyauchi, Chikaya Omichi, huinam pak, Lauren A. Brodsky, William J. Mandel, Michael C. Fishbein, Hrayr S. Karagueuzian, Peng Sheng Chen

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Abstract

OBJECTIVES: The study examined the activations in the pulmonary veins (PVs) and the vein of Marshall (VOM) during atrial fibrillation (AF) in dogs with congestive heart failure (CHF). BACKGROUND: The patterns of activation within the PVs and the VOM during AF in CHF are unclear. METHODS: We induced CHF in nine dogs by rapid ventricular pacing. The patterns of activation during induced AF were studied one week after ceasing ventricular pacing. RESULTS: The duration of induced AF averaged 80.7 ± 177.3 s. The termination of low-amplitude fractionated activity in the PVs preceded the termination of AF in 25 of 29 episodes. High-density mapping (1-mm resolution) showed that the PV was activated by a focal wave front independent of left atrial (LA) activation in 22 AF episodes. Frequent intra-PV conduction blocks and multiple wave fronts in the PVs were recorded during 10 AF episodes. Focal activations were observed within the VOM in 4 of 12 episodes of AF. Three atrial tachycardia (AT) episodes originated from a focus within a PV. Histological studies showed extensive fibrosis in the PVs and in the atria. The PVs in five normal dogs did not have focal or fractionated activity during induced AF. CONCLUSIONS: Atrial fibrillation in canine CHF is associated with independent focal activations in the PVs and the VOM, and with complex wave fronts within the PVs. The PVs may also serve as the origin of AT. These findings suggest that electrical and anatomical remodeling of the PVs and the VOM are important in the maintenance of AF and AT in dogs with CHF.

Original languageEnglish
Pages (from-to)348-360
Number of pages13
JournalJournal of the American College of Cardiology
Volume42
Issue number2
DOIs
Publication statusPublished - 2003 Jul 16

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Pulmonary Veins
Tachycardia
Atrial Fibrillation
Canidae
Veins
Heart Failure
Dogs
carbosulfan
Atrial Remodeling
Fibrosis

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Okuyama, Yuji ; Miyauchi, Yasushi ; Park, Angela M. ; Hamabe, Akira ; Zhou, Shengmei ; Hayashi, Hideki ; Miyauchi, Mizuho ; Omichi, Chikaya ; pak, huinam ; Brodsky, Lauren A. ; Mandel, William J. ; Fishbein, Michael C. ; Karagueuzian, Hrayr S. ; Chen, Peng Sheng. / High resolution mapping of the pulmonary vein and the vein of marshall during induced atrial fibrillation and atrial tachycardia in a canine model of pacing-induced congestive heart failure. In: Journal of the American College of Cardiology. 2003 ; Vol. 42, No. 2. pp. 348-360.
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title = "High resolution mapping of the pulmonary vein and the vein of marshall during induced atrial fibrillation and atrial tachycardia in a canine model of pacing-induced congestive heart failure",
abstract = "OBJECTIVES: The study examined the activations in the pulmonary veins (PVs) and the vein of Marshall (VOM) during atrial fibrillation (AF) in dogs with congestive heart failure (CHF). BACKGROUND: The patterns of activation within the PVs and the VOM during AF in CHF are unclear. METHODS: We induced CHF in nine dogs by rapid ventricular pacing. The patterns of activation during induced AF were studied one week after ceasing ventricular pacing. RESULTS: The duration of induced AF averaged 80.7 ± 177.3 s. The termination of low-amplitude fractionated activity in the PVs preceded the termination of AF in 25 of 29 episodes. High-density mapping (1-mm resolution) showed that the PV was activated by a focal wave front independent of left atrial (LA) activation in 22 AF episodes. Frequent intra-PV conduction blocks and multiple wave fronts in the PVs were recorded during 10 AF episodes. Focal activations were observed within the VOM in 4 of 12 episodes of AF. Three atrial tachycardia (AT) episodes originated from a focus within a PV. Histological studies showed extensive fibrosis in the PVs and in the atria. The PVs in five normal dogs did not have focal or fractionated activity during induced AF. CONCLUSIONS: Atrial fibrillation in canine CHF is associated with independent focal activations in the PVs and the VOM, and with complex wave fronts within the PVs. The PVs may also serve as the origin of AT. These findings suggest that electrical and anatomical remodeling of the PVs and the VOM are important in the maintenance of AF and AT in dogs with CHF.",
author = "Yuji Okuyama and Yasushi Miyauchi and Park, {Angela M.} and Akira Hamabe and Shengmei Zhou and Hideki Hayashi and Mizuho Miyauchi and Chikaya Omichi and huinam pak and Brodsky, {Lauren A.} and Mandel, {William J.} and Fishbein, {Michael C.} and Karagueuzian, {Hrayr S.} and Chen, {Peng Sheng}",
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Okuyama, Y, Miyauchi, Y, Park, AM, Hamabe, A, Zhou, S, Hayashi, H, Miyauchi, M, Omichi, C, pak, H, Brodsky, LA, Mandel, WJ, Fishbein, MC, Karagueuzian, HS & Chen, PS 2003, 'High resolution mapping of the pulmonary vein and the vein of marshall during induced atrial fibrillation and atrial tachycardia in a canine model of pacing-induced congestive heart failure', Journal of the American College of Cardiology, vol. 42, no. 2, pp. 348-360. https://doi.org/10.1016/S0735-1097(03)00586-2

High resolution mapping of the pulmonary vein and the vein of marshall during induced atrial fibrillation and atrial tachycardia in a canine model of pacing-induced congestive heart failure. / Okuyama, Yuji; Miyauchi, Yasushi; Park, Angela M.; Hamabe, Akira; Zhou, Shengmei; Hayashi, Hideki; Miyauchi, Mizuho; Omichi, Chikaya; pak, huinam; Brodsky, Lauren A.; Mandel, William J.; Fishbein, Michael C.; Karagueuzian, Hrayr S.; Chen, Peng Sheng.

In: Journal of the American College of Cardiology, Vol. 42, No. 2, 16.07.2003, p. 348-360.

Research output: Contribution to journalArticle

TY - JOUR

T1 - High resolution mapping of the pulmonary vein and the vein of marshall during induced atrial fibrillation and atrial tachycardia in a canine model of pacing-induced congestive heart failure

AU - Okuyama, Yuji

AU - Miyauchi, Yasushi

AU - Park, Angela M.

AU - Hamabe, Akira

AU - Zhou, Shengmei

AU - Hayashi, Hideki

AU - Miyauchi, Mizuho

AU - Omichi, Chikaya

AU - pak, huinam

AU - Brodsky, Lauren A.

AU - Mandel, William J.

AU - Fishbein, Michael C.

AU - Karagueuzian, Hrayr S.

AU - Chen, Peng Sheng

PY - 2003/7/16

Y1 - 2003/7/16

N2 - OBJECTIVES: The study examined the activations in the pulmonary veins (PVs) and the vein of Marshall (VOM) during atrial fibrillation (AF) in dogs with congestive heart failure (CHF). BACKGROUND: The patterns of activation within the PVs and the VOM during AF in CHF are unclear. METHODS: We induced CHF in nine dogs by rapid ventricular pacing. The patterns of activation during induced AF were studied one week after ceasing ventricular pacing. RESULTS: The duration of induced AF averaged 80.7 ± 177.3 s. The termination of low-amplitude fractionated activity in the PVs preceded the termination of AF in 25 of 29 episodes. High-density mapping (1-mm resolution) showed that the PV was activated by a focal wave front independent of left atrial (LA) activation in 22 AF episodes. Frequent intra-PV conduction blocks and multiple wave fronts in the PVs were recorded during 10 AF episodes. Focal activations were observed within the VOM in 4 of 12 episodes of AF. Three atrial tachycardia (AT) episodes originated from a focus within a PV. Histological studies showed extensive fibrosis in the PVs and in the atria. The PVs in five normal dogs did not have focal or fractionated activity during induced AF. CONCLUSIONS: Atrial fibrillation in canine CHF is associated with independent focal activations in the PVs and the VOM, and with complex wave fronts within the PVs. The PVs may also serve as the origin of AT. These findings suggest that electrical and anatomical remodeling of the PVs and the VOM are important in the maintenance of AF and AT in dogs with CHF.

AB - OBJECTIVES: The study examined the activations in the pulmonary veins (PVs) and the vein of Marshall (VOM) during atrial fibrillation (AF) in dogs with congestive heart failure (CHF). BACKGROUND: The patterns of activation within the PVs and the VOM during AF in CHF are unclear. METHODS: We induced CHF in nine dogs by rapid ventricular pacing. The patterns of activation during induced AF were studied one week after ceasing ventricular pacing. RESULTS: The duration of induced AF averaged 80.7 ± 177.3 s. The termination of low-amplitude fractionated activity in the PVs preceded the termination of AF in 25 of 29 episodes. High-density mapping (1-mm resolution) showed that the PV was activated by a focal wave front independent of left atrial (LA) activation in 22 AF episodes. Frequent intra-PV conduction blocks and multiple wave fronts in the PVs were recorded during 10 AF episodes. Focal activations were observed within the VOM in 4 of 12 episodes of AF. Three atrial tachycardia (AT) episodes originated from a focus within a PV. Histological studies showed extensive fibrosis in the PVs and in the atria. The PVs in five normal dogs did not have focal or fractionated activity during induced AF. CONCLUSIONS: Atrial fibrillation in canine CHF is associated with independent focal activations in the PVs and the VOM, and with complex wave fronts within the PVs. The PVs may also serve as the origin of AT. These findings suggest that electrical and anatomical remodeling of the PVs and the VOM are important in the maintenance of AF and AT in dogs with CHF.

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