High-risk clinicopathological features and their predictive significance in Korean patients with stage II colon cancer

Ji Soo Park, Hong Jae Chon, Hei Cheul Jeung, Sang Joon Shin, Sun Young Rha, Joong Bae Ahn, Kang Young Lee, Nam Kyu Kim, Hyun Cheol Chung

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Purpose: We investigated the prognostic factors for recurrence in Korean patients with stage II colon cancer and evaluated their predictive significance with 5-fluorouracil (FU)-based adjuvant chemotherapy. Methods: We analyzed the relationship between clinicopathological features and relapse-free survival (RFS) of 716 stage II colon cancer patients who underwent curative resection. Predictive values were assessed using 5-year RFS and 5-year cancer-specific survival (CSS). Results: The 5-year RFS, 5-year CSS, 5-year disease-free survival, and 5-year overall survival rates were 87.4, 94.9, 84.8, and 90.5 %, respectively. T4 stage (hazard ratio [HR], 2.342; 95 % confidence interval [CI], 1.348–4.068; p = 0.003), preoperative bowel obstruction or perforation (HR 2.428; 95 % CI 1.241–4.752; p = 0.010), and age older than 70 years (HR 1.740; 95 % CI 1.130–2.678; p = 0.012) were poor prognostic factors for recurrence in multiple Cox regression analyses. In 60 patients with T4 disease, 5-FU-based adjuvant chemotherapy was associated with improved 5-year CSS of the patients (90.3 vs. 46.7 %; HR 0.135; 95 % CI 0.035–0.517; p = 0.003). Conclusions: We found discordance between the risk factors for recurrence and the predictive value for 5-FU-based adjuvant chemotherapy in Korean patients with stage II colon cancer. Future prospective clinical trials selectively targeting high-risk patients are needed.

Original languageEnglish
Pages (from-to)2051-2059
Number of pages9
JournalJournal of cancer research and clinical oncology
Volume142
Issue number9
DOIs
Publication statusPublished - 2016 Sep 1

Bibliographical note

Funding Information:
The authors are grateful for the support provided by a grant from the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (Grant Number 0405-BC01-0604-0002).

Publisher Copyright:
© 2016, Springer-Verlag Berlin Heidelberg.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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