High risk of hepatocellular carcinoma development in fibrotic liver: Role of the hippo-YAP/TAZ signaling pathway

Hyuk Moon, Kyungjoo Cho, Sunyeong Shin, Do Young Kim, Kwang Hyub Han, Simon Weonsang Ro

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Liver cancer is the fourth leading cause of cancer-related death globally, accounting for approximately 800,000 deaths annually. Hepatocellular carcinoma (HCC) is the most common type of liver cancer, making up about 80% of cases. Liver fibrosis and its end-stage disease, cirrhosis, are major risk factors for HCC. A fibrotic liver typically shows persistent hepatocyte death and compensatory regeneration, chronic inflammation, and an increase in reactive oxygen species, which collaboratively create a tumor-promoting microenvironment via inducing genetic alterations and chromosomal instability, and activating various oncogenic molecular signaling pathways. In this article, we review recent advances in fields of liver fibrosis and carcinogenesis, and consider several molecular signaling pathways that promote hepato-carcinogenesis under the microenvironment of liver fibrosis. In particular, we pay attention to emerging roles of the Hippo-YAP/TAZ signaling pathway in stromal activation, hepatic fibrosis, and liver cancer.

Original languageEnglish
Article number581
JournalInternational journal of molecular sciences
Volume20
Issue number3
DOIs
Publication statusPublished - 2019 Feb 1

Fingerprint

Liver Neoplasms
liver
Liver
Hepatocellular Carcinoma
cancer
fibrosis
Liver Cirrhosis
death
Carcinogenesis
Fibrosis
Chromosomal Instability
Tumor Microenvironment
Regeneration
Hepatocytes
Reactive Oxygen Species
Inflammation
regeneration
Tumors
emerging
tumors

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

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title = "High risk of hepatocellular carcinoma development in fibrotic liver: Role of the hippo-YAP/TAZ signaling pathway",
abstract = "Liver cancer is the fourth leading cause of cancer-related death globally, accounting for approximately 800,000 deaths annually. Hepatocellular carcinoma (HCC) is the most common type of liver cancer, making up about 80{\%} of cases. Liver fibrosis and its end-stage disease, cirrhosis, are major risk factors for HCC. A fibrotic liver typically shows persistent hepatocyte death and compensatory regeneration, chronic inflammation, and an increase in reactive oxygen species, which collaboratively create a tumor-promoting microenvironment via inducing genetic alterations and chromosomal instability, and activating various oncogenic molecular signaling pathways. In this article, we review recent advances in fields of liver fibrosis and carcinogenesis, and consider several molecular signaling pathways that promote hepato-carcinogenesis under the microenvironment of liver fibrosis. In particular, we pay attention to emerging roles of the Hippo-YAP/TAZ signaling pathway in stromal activation, hepatic fibrosis, and liver cancer.",
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High risk of hepatocellular carcinoma development in fibrotic liver : Role of the hippo-YAP/TAZ signaling pathway. / Moon, Hyuk; Cho, Kyungjoo; Shin, Sunyeong; Kim, Do Young; Han, Kwang Hyub; Ro, Simon Weonsang.

In: International journal of molecular sciences, Vol. 20, No. 3, 581, 01.02.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - High risk of hepatocellular carcinoma development in fibrotic liver

T2 - Role of the hippo-YAP/TAZ signaling pathway

AU - Moon, Hyuk

AU - Cho, Kyungjoo

AU - Shin, Sunyeong

AU - Kim, Do Young

AU - Han, Kwang Hyub

AU - Ro, Simon Weonsang

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Liver cancer is the fourth leading cause of cancer-related death globally, accounting for approximately 800,000 deaths annually. Hepatocellular carcinoma (HCC) is the most common type of liver cancer, making up about 80% of cases. Liver fibrosis and its end-stage disease, cirrhosis, are major risk factors for HCC. A fibrotic liver typically shows persistent hepatocyte death and compensatory regeneration, chronic inflammation, and an increase in reactive oxygen species, which collaboratively create a tumor-promoting microenvironment via inducing genetic alterations and chromosomal instability, and activating various oncogenic molecular signaling pathways. In this article, we review recent advances in fields of liver fibrosis and carcinogenesis, and consider several molecular signaling pathways that promote hepato-carcinogenesis under the microenvironment of liver fibrosis. In particular, we pay attention to emerging roles of the Hippo-YAP/TAZ signaling pathway in stromal activation, hepatic fibrosis, and liver cancer.

AB - Liver cancer is the fourth leading cause of cancer-related death globally, accounting for approximately 800,000 deaths annually. Hepatocellular carcinoma (HCC) is the most common type of liver cancer, making up about 80% of cases. Liver fibrosis and its end-stage disease, cirrhosis, are major risk factors for HCC. A fibrotic liver typically shows persistent hepatocyte death and compensatory regeneration, chronic inflammation, and an increase in reactive oxygen species, which collaboratively create a tumor-promoting microenvironment via inducing genetic alterations and chromosomal instability, and activating various oncogenic molecular signaling pathways. In this article, we review recent advances in fields of liver fibrosis and carcinogenesis, and consider several molecular signaling pathways that promote hepato-carcinogenesis under the microenvironment of liver fibrosis. In particular, we pay attention to emerging roles of the Hippo-YAP/TAZ signaling pathway in stromal activation, hepatic fibrosis, and liver cancer.

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