High-sensitivity C-reactive protein is independently associated with arterial stiffness in women with metabolic syndrome

Euigeum Oh, Soo Hyun Kim, So Youn Bang, Sa Saeng Hyun, Jee Aee Im, Jung Eun Lee, Jae Yong Yoo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Metabolic syndrome (MetS) is associated with higher incidences of cardiovascular events and with increased mortality from coronary heart disease. There is increasing evidence that MetS presents as a proinflammatory and prothrombotic state. Objectives: The purposes of this study were to investigate the relationships among adiponectin (a marker for adipocytokines), high-sensitivity C-reactive protein (hs-CRP, a marker for inflammation), and brachial-ankle pulse-wave velocity (ba-PWV, a marker for arterial stiffness) in MetS and to identify predictors of ba-PWV, which indicates subclinical atherosclerosis. Methods: The present study is a cross-sectional, secondary analysis of data collected as part of a longitudinal, randomized controlled trial that tested the effectiveness of a therapeutic lifestyle modification for Korean women with MetS (N = 52). We used the definition for MetS suggested by the National Cholesterol Education Program Adult Treatment Panel III. Results: Adiponectin was negatively correlated with hs-CRP (r = -0.316, P = .027) and ba-PWV (r = -0.284, P = .048), and hs-CRP was positively correlated with ba-PWV (r = 0.341, P = .016). Women with high hs-CRP and low adiponectin levels also had greater ba-PWV levels (P = .041). Levels of hs-CRP were independently associated with ba-PWV after adjusting for age, body mass index, and number of MetS components, whereas no independent association was identified for adiponectin. Conclusion: Levels of hs-CRP may provide important prognostic information in terms of future cardiovascular risk in women with MetS.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalJournal of Cardiovascular Nursing
Volume27
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

Fingerprint

Vascular Stiffness
C-Reactive Protein
Adiponectin
Pulse Wave Analysis
Adipokines
Ankle
Coronary Disease
Life Style
Atherosclerosis
Body Mass Index
Arm
Randomized Controlled Trials
Cross-Sectional Studies
Cholesterol
Inflammation
Education
Mortality
Incidence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

Cite this

Oh, Euigeum ; Kim, Soo Hyun ; Bang, So Youn ; Hyun, Sa Saeng ; Im, Jee Aee ; Lee, Jung Eun ; Yoo, Jae Yong. / High-sensitivity C-reactive protein is independently associated with arterial stiffness in women with metabolic syndrome. In: Journal of Cardiovascular Nursing. 2012 ; Vol. 27, No. 1. pp. 61-67.
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High-sensitivity C-reactive protein is independently associated with arterial stiffness in women with metabolic syndrome. / Oh, Euigeum; Kim, Soo Hyun; Bang, So Youn; Hyun, Sa Saeng; Im, Jee Aee; Lee, Jung Eun; Yoo, Jae Yong.

In: Journal of Cardiovascular Nursing, Vol. 27, No. 1, 01.01.2012, p. 61-67.

Research output: Contribution to journalArticle

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AU - Oh, Euigeum

AU - Kim, Soo Hyun

AU - Bang, So Youn

AU - Hyun, Sa Saeng

AU - Im, Jee Aee

AU - Lee, Jung Eun

AU - Yoo, Jae Yong

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N2 - Background: Metabolic syndrome (MetS) is associated with higher incidences of cardiovascular events and with increased mortality from coronary heart disease. There is increasing evidence that MetS presents as a proinflammatory and prothrombotic state. Objectives: The purposes of this study were to investigate the relationships among adiponectin (a marker for adipocytokines), high-sensitivity C-reactive protein (hs-CRP, a marker for inflammation), and brachial-ankle pulse-wave velocity (ba-PWV, a marker for arterial stiffness) in MetS and to identify predictors of ba-PWV, which indicates subclinical atherosclerosis. Methods: The present study is a cross-sectional, secondary analysis of data collected as part of a longitudinal, randomized controlled trial that tested the effectiveness of a therapeutic lifestyle modification for Korean women with MetS (N = 52). We used the definition for MetS suggested by the National Cholesterol Education Program Adult Treatment Panel III. Results: Adiponectin was negatively correlated with hs-CRP (r = -0.316, P = .027) and ba-PWV (r = -0.284, P = .048), and hs-CRP was positively correlated with ba-PWV (r = 0.341, P = .016). Women with high hs-CRP and low adiponectin levels also had greater ba-PWV levels (P = .041). Levels of hs-CRP were independently associated with ba-PWV after adjusting for age, body mass index, and number of MetS components, whereas no independent association was identified for adiponectin. Conclusion: Levels of hs-CRP may provide important prognostic information in terms of future cardiovascular risk in women with MetS.

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