High-sensitivity C-reactive protein is independently associated with arterial stiffness in women with metabolic syndrome

Eui Geum Oh, Soo Hyun Kim, So Youn Bang, Sa Saeng Hyun, Jee Aee Im, Jung Eun Lee, Jae Yong Yoo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Metabolic syndrome (MetS) is associated with higher incidences of cardiovascular events and with increased mortality from coronary heart disease. There is increasing evidence that MetS presents as a proinflammatory and prothrombotic state. Objectives: The purposes of this study were to investigate the relationships among adiponectin (a marker for adipocytokines), high-sensitivity C-reactive protein (hs-CRP, a marker for inflammation), and brachial-ankle pulse-wave velocity (ba-PWV, a marker for arterial stiffness) in MetS and to identify predictors of ba-PWV, which indicates subclinical atherosclerosis. Methods: The present study is a cross-sectional, secondary analysis of data collected as part of a longitudinal, randomized controlled trial that tested the effectiveness of a therapeutic lifestyle modification for Korean women with MetS (N = 52). We used the definition for MetS suggested by the National Cholesterol Education Program Adult Treatment Panel III. Results: Adiponectin was negatively correlated with hs-CRP (r = -0.316, P = .027) and ba-PWV (r = -0.284, P = .048), and hs-CRP was positively correlated with ba-PWV (r = 0.341, P = .016). Women with high hs-CRP and low adiponectin levels also had greater ba-PWV levels (P = .041). Levels of hs-CRP were independently associated with ba-PWV after adjusting for age, body mass index, and number of MetS components, whereas no independent association was identified for adiponectin. Conclusion: Levels of hs-CRP may provide important prognostic information in terms of future cardiovascular risk in women with MetS.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalJournal of Cardiovascular Nursing
Volume27
Issue number1
DOIs
Publication statusPublished - 2012 Jan

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

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