High serum adiponectin is associated with anemia development in chronic kidney disease: The results from the KNOW-CKD study

Hyoungnae Kim, Hae Ryong Yun, Seohyun Park, Jong Hyun Jhee, Jung Tak Park, Tae Hyun Yoo, Kyu Beck Lee, Yeong Hoon Kim, Su Ah Sung, Joongyub Lee, Shin Wook Kang, Kyu Hun Choi, Curie Ahn, Seung Hyeok Han

Research output: Contribution to journalArticle

Abstract

Background Adiponectin is an adipokine secreted by adipocytes. A low adiponectin level is a significant risk factor of diabetes mellitus and cardiovascular disease. Recent studies have shown that adiponectin is negatively associated with hematopoiesis and predicts the development of anemia in the general population. In chronic kidney disease (CKD) patients, circulating adiponectin level is paradoxically elevated and the role of adiponectin is complex. Therefore, we evaluated the relationship between adiponectin and anemia in these patients. Methods This prospective longitudinal study included 2113 patients from the KNOW-CKD study (KoreaN cohort study for Outcome in patients With CKD), after excluding 125 without data on adiponectin levels. Hemoglobin levels were measured yearly during a mean follow-up period of 23.7 months. Anemia was defined as hemoglobin levels of <13.0 and 12.0 g/dL for men and women, respectively. Results Mean patient age was 53.6 ± 12.2 years, and 1289 (61%) were men. The mean estimated glomerular filtration rate (eGFR) was 50.4 ± 30.2 mL min−1 1.73 m−2. Serum adiponectin level was inversely associated with body mass index, eGFR, log-transformed C-reactive protein, and positively with Charlson comorbidity index, urine protein to creatinine ratio, and high density lipoprotein cholesterol. In addition, serum adiponectin level was also negatively correlated with hemoglobin level and reticulocyte production index in both men and women. In multivariable linear regression analysis after adjustment of multiple confounders, adiponectin was negatively associated with hemoglobin (men, β = −0.219, P <.001; women, β = −0.09, P =.025). Among 1227 patients without anemia at baseline, 307 newly developed anemia during the follow-up period. In multivariable Cox regression analysis after adjustment of confounders, high adiponectin level was significantly associated with an increased risk of incident anemia (per 1 µg/mL increase, hazard ratio, 1.02; 95% confidence interval 1.01–1.04; P =.001). Conclusions A high serum adiponectin level is independently associated with a low hemoglobin level and predicts the development of anemia in patients with CKD. These findings reveal the potential role of adiponectin in CKD-related anemia.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalCytokine
Volume103
DOIs
Publication statusPublished - 2018 Mar

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Adiponectin
Chronic Renal Insufficiency
Anemia
Serum
Hemoglobins
Glomerular Filtration Rate
Regression analysis
Regression Analysis
Adipokines
Reticulocytes
Hematopoiesis
Medical problems
Adipocytes
Linear regression
C-Reactive Protein
HDL Cholesterol
Longitudinal Studies
Comorbidity
Linear Models
Creatinine

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

Cite this

Kim, Hyoungnae ; Yun, Hae Ryong ; Park, Seohyun ; Jhee, Jong Hyun ; Park, Jung Tak ; Yoo, Tae Hyun ; Lee, Kyu Beck ; Kim, Yeong Hoon ; Sung, Su Ah ; Lee, Joongyub ; Kang, Shin Wook ; Choi, Kyu Hun ; Ahn, Curie ; Han, Seung Hyeok. / High serum adiponectin is associated with anemia development in chronic kidney disease : The results from the KNOW-CKD study. In: Cytokine. 2018 ; Vol. 103. pp. 1-9.
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abstract = "Background Adiponectin is an adipokine secreted by adipocytes. A low adiponectin level is a significant risk factor of diabetes mellitus and cardiovascular disease. Recent studies have shown that adiponectin is negatively associated with hematopoiesis and predicts the development of anemia in the general population. In chronic kidney disease (CKD) patients, circulating adiponectin level is paradoxically elevated and the role of adiponectin is complex. Therefore, we evaluated the relationship between adiponectin and anemia in these patients. Methods This prospective longitudinal study included 2113 patients from the KNOW-CKD study (KoreaN cohort study for Outcome in patients With CKD), after excluding 125 without data on adiponectin levels. Hemoglobin levels were measured yearly during a mean follow-up period of 23.7 months. Anemia was defined as hemoglobin levels of <13.0 and 12.0 g/dL for men and women, respectively. Results Mean patient age was 53.6 ± 12.2 years, and 1289 (61{\%}) were men. The mean estimated glomerular filtration rate (eGFR) was 50.4 ± 30.2 mL min−1 1.73 m−2. Serum adiponectin level was inversely associated with body mass index, eGFR, log-transformed C-reactive protein, and positively with Charlson comorbidity index, urine protein to creatinine ratio, and high density lipoprotein cholesterol. In addition, serum adiponectin level was also negatively correlated with hemoglobin level and reticulocyte production index in both men and women. In multivariable linear regression analysis after adjustment of multiple confounders, adiponectin was negatively associated with hemoglobin (men, β = −0.219, P <.001; women, β = −0.09, P =.025). Among 1227 patients without anemia at baseline, 307 newly developed anemia during the follow-up period. In multivariable Cox regression analysis after adjustment of confounders, high adiponectin level was significantly associated with an increased risk of incident anemia (per 1 µg/mL increase, hazard ratio, 1.02; 95{\%} confidence interval 1.01–1.04; P =.001). Conclusions A high serum adiponectin level is independently associated with a low hemoglobin level and predicts the development of anemia in patients with CKD. These findings reveal the potential role of adiponectin in CKD-related anemia.",
author = "Hyoungnae Kim and Yun, {Hae Ryong} and Seohyun Park and Jhee, {Jong Hyun} and Park, {Jung Tak} and Yoo, {Tae Hyun} and Lee, {Kyu Beck} and Kim, {Yeong Hoon} and Sung, {Su Ah} and Joongyub Lee and Kang, {Shin Wook} and Choi, {Kyu Hun} and Curie Ahn and Han, {Seung Hyeok}",
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High serum adiponectin is associated with anemia development in chronic kidney disease : The results from the KNOW-CKD study. / Kim, Hyoungnae; Yun, Hae Ryong; Park, Seohyun; Jhee, Jong Hyun; Park, Jung Tak; Yoo, Tae Hyun; Lee, Kyu Beck; Kim, Yeong Hoon; Sung, Su Ah; Lee, Joongyub; Kang, Shin Wook; Choi, Kyu Hun; Ahn, Curie; Han, Seung Hyeok.

In: Cytokine, Vol. 103, 03.2018, p. 1-9.

Research output: Contribution to journalArticle

TY - JOUR

T1 - High serum adiponectin is associated with anemia development in chronic kidney disease

T2 - The results from the KNOW-CKD study

AU - Kim, Hyoungnae

AU - Yun, Hae Ryong

AU - Park, Seohyun

AU - Jhee, Jong Hyun

AU - Park, Jung Tak

AU - Yoo, Tae Hyun

AU - Lee, Kyu Beck

AU - Kim, Yeong Hoon

AU - Sung, Su Ah

AU - Lee, Joongyub

AU - Kang, Shin Wook

AU - Choi, Kyu Hun

AU - Ahn, Curie

AU - Han, Seung Hyeok

PY - 2018/3

Y1 - 2018/3

N2 - Background Adiponectin is an adipokine secreted by adipocytes. A low adiponectin level is a significant risk factor of diabetes mellitus and cardiovascular disease. Recent studies have shown that adiponectin is negatively associated with hematopoiesis and predicts the development of anemia in the general population. In chronic kidney disease (CKD) patients, circulating adiponectin level is paradoxically elevated and the role of adiponectin is complex. Therefore, we evaluated the relationship between adiponectin and anemia in these patients. Methods This prospective longitudinal study included 2113 patients from the KNOW-CKD study (KoreaN cohort study for Outcome in patients With CKD), after excluding 125 without data on adiponectin levels. Hemoglobin levels were measured yearly during a mean follow-up period of 23.7 months. Anemia was defined as hemoglobin levels of <13.0 and 12.0 g/dL for men and women, respectively. Results Mean patient age was 53.6 ± 12.2 years, and 1289 (61%) were men. The mean estimated glomerular filtration rate (eGFR) was 50.4 ± 30.2 mL min−1 1.73 m−2. Serum adiponectin level was inversely associated with body mass index, eGFR, log-transformed C-reactive protein, and positively with Charlson comorbidity index, urine protein to creatinine ratio, and high density lipoprotein cholesterol. In addition, serum adiponectin level was also negatively correlated with hemoglobin level and reticulocyte production index in both men and women. In multivariable linear regression analysis after adjustment of multiple confounders, adiponectin was negatively associated with hemoglobin (men, β = −0.219, P <.001; women, β = −0.09, P =.025). Among 1227 patients without anemia at baseline, 307 newly developed anemia during the follow-up period. In multivariable Cox regression analysis after adjustment of confounders, high adiponectin level was significantly associated with an increased risk of incident anemia (per 1 µg/mL increase, hazard ratio, 1.02; 95% confidence interval 1.01–1.04; P =.001). Conclusions A high serum adiponectin level is independently associated with a low hemoglobin level and predicts the development of anemia in patients with CKD. These findings reveal the potential role of adiponectin in CKD-related anemia.

AB - Background Adiponectin is an adipokine secreted by adipocytes. A low adiponectin level is a significant risk factor of diabetes mellitus and cardiovascular disease. Recent studies have shown that adiponectin is negatively associated with hematopoiesis and predicts the development of anemia in the general population. In chronic kidney disease (CKD) patients, circulating adiponectin level is paradoxically elevated and the role of adiponectin is complex. Therefore, we evaluated the relationship between adiponectin and anemia in these patients. Methods This prospective longitudinal study included 2113 patients from the KNOW-CKD study (KoreaN cohort study for Outcome in patients With CKD), after excluding 125 without data on adiponectin levels. Hemoglobin levels were measured yearly during a mean follow-up period of 23.7 months. Anemia was defined as hemoglobin levels of <13.0 and 12.0 g/dL for men and women, respectively. Results Mean patient age was 53.6 ± 12.2 years, and 1289 (61%) were men. The mean estimated glomerular filtration rate (eGFR) was 50.4 ± 30.2 mL min−1 1.73 m−2. Serum adiponectin level was inversely associated with body mass index, eGFR, log-transformed C-reactive protein, and positively with Charlson comorbidity index, urine protein to creatinine ratio, and high density lipoprotein cholesterol. In addition, serum adiponectin level was also negatively correlated with hemoglobin level and reticulocyte production index in both men and women. In multivariable linear regression analysis after adjustment of multiple confounders, adiponectin was negatively associated with hemoglobin (men, β = −0.219, P <.001; women, β = −0.09, P =.025). Among 1227 patients without anemia at baseline, 307 newly developed anemia during the follow-up period. In multivariable Cox regression analysis after adjustment of confounders, high adiponectin level was significantly associated with an increased risk of incident anemia (per 1 µg/mL increase, hazard ratio, 1.02; 95% confidence interval 1.01–1.04; P =.001). Conclusions A high serum adiponectin level is independently associated with a low hemoglobin level and predicts the development of anemia in patients with CKD. These findings reveal the potential role of adiponectin in CKD-related anemia.

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