High serum advanced glycation end-products predict coronary artery disease irrespective of arterial stiffness in diabetic patients

Ki Bum Won, Hyuk Jae Chang, Sung Ha Park, Sung Yu Hong, Yangsoo Jang, Namsik Chung

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Abstract

Background and Objectives: Advanced glycation end-products (AGEs) contribute to the development of atherosclerosis. We investigated whether serum AGEs are related to the presence or severity of coronary artery disease (CAD), and explored the association between serum AGEs and arterial stiffness according to diabetes status in patients suspected of having CAD. Subjects and Methods: The measurement of serum AGEs and brachial-ankle pulse wave velocity (baPWV) were performed in 145 consecutive patients (63±9 years, 58% men) who received a coronary angiogram for evaluation of CAD. Results: Forty-four diabetics and 101 non-diabetics were classified into three subgroups based on the number of diseased vessels with obstructive CAD: 0, 1, and 2 or more vessel diseases (VDs). Serum AGEs were significantly higher in diabetics with obstructive CAD than in those without obstructive CAD (2.16±0.29 vs. 1.85±0.29 mU/mL, p=0.010) and were significantly correlated with the number of VDs only in diabetics (r=0.504, p<0.001). Serum AGEs were not significantly correlated with baPWV in diabetics or non-diabetics. In receiver operating characteristics analysis, the cut-off value of serum AGEs as a predictor of obstructive CAD was 1.98 mU/mL, with 64% sensitivity and 63% specificity in diabetics. In multiple regression analysis, serum AGEs independently predicted obstructive CAD and were associated with the number of VDs in diabetics. Conclusion: Serum AGEs independently predict obstructive CAD and the severity of coronary atherosclerosis irrespective of arterial stiffness only in diabetics. Evaluation of PWV and serum AGEs together may be more effective to identify the risk of CAD in diabetic individuals.

Original languageEnglish
Pages (from-to)335-340
Number of pages6
JournalKorean Circulation Journal
Volume42
Issue number5
DOIs
Publication statusPublished - 2012 May 1

Fingerprint

Vascular Stiffness
Advanced Glycosylation End Products
Coronary Artery Disease
Serum
Pulse Wave Analysis
Ankle
Arm
ROC Curve
Atherosclerosis
Angiography
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "High serum advanced glycation end-products predict coronary artery disease irrespective of arterial stiffness in diabetic patients",
abstract = "Background and Objectives: Advanced glycation end-products (AGEs) contribute to the development of atherosclerosis. We investigated whether serum AGEs are related to the presence or severity of coronary artery disease (CAD), and explored the association between serum AGEs and arterial stiffness according to diabetes status in patients suspected of having CAD. Subjects and Methods: The measurement of serum AGEs and brachial-ankle pulse wave velocity (baPWV) were performed in 145 consecutive patients (63±9 years, 58{\%} men) who received a coronary angiogram for evaluation of CAD. Results: Forty-four diabetics and 101 non-diabetics were classified into three subgroups based on the number of diseased vessels with obstructive CAD: 0, 1, and 2 or more vessel diseases (VDs). Serum AGEs were significantly higher in diabetics with obstructive CAD than in those without obstructive CAD (2.16±0.29 vs. 1.85±0.29 mU/mL, p=0.010) and were significantly correlated with the number of VDs only in diabetics (r=0.504, p<0.001). Serum AGEs were not significantly correlated with baPWV in diabetics or non-diabetics. In receiver operating characteristics analysis, the cut-off value of serum AGEs as a predictor of obstructive CAD was 1.98 mU/mL, with 64{\%} sensitivity and 63{\%} specificity in diabetics. In multiple regression analysis, serum AGEs independently predicted obstructive CAD and were associated with the number of VDs in diabetics. Conclusion: Serum AGEs independently predict obstructive CAD and the severity of coronary atherosclerosis irrespective of arterial stiffness only in diabetics. Evaluation of PWV and serum AGEs together may be more effective to identify the risk of CAD in diabetic individuals.",
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High serum advanced glycation end-products predict coronary artery disease irrespective of arterial stiffness in diabetic patients. / Won, Ki Bum; Chang, Hyuk Jae; Park, Sung Ha; Hong, Sung Yu; Jang, Yangsoo; Chung, Namsik.

In: Korean Circulation Journal, Vol. 42, No. 5, 01.05.2012, p. 335-340.

Research output: Contribution to journalArticle

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