High-throughput of photodynamic therapy (PDT) screening from multiple parameter assays of 1,000 different conditions in a single chip

X. Lou, G. Kim, Y. Koo, R. Kopelman, Euisik Yoon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

We present a microfluidic chip for high-throughput PDT screening with the capability of individual controls on light exposure dose, pericellular oxygen level and photosensitizer concentration. Both oxygen and photosensitizer gradients are produced by microfluidic gradient-generating networks and imposed on target cells. Various photo-exposures are provided by orthogonally stacking the two layers of gray scale liquid filters. All three parameters are independently controlled in the microfluidic channels monolithically integrated in a single chip. Using this platform, we successfully demonstrated the PDT efficacy on cancer cells for different exposure doses, oxygen levels and photosensitizer concentrations.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages719-721
Number of pages3
Publication statusPublished - 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 2010 Oct 32010 Oct 7

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume2

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/10/310/10/7

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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