Higher education affects accelerated cortical thinning in Alzheimer's disease: A 5-year preliminary longitudinal study

Hanna Cho, Seun Jeon, Changsoo Kim, Byoung Seok Ye, Geon Ha Kim, Young Noh, Hee Jin Kim, Cindy W. Yoon, Yeo Jin Kim, Jung Hyun Kim, Sang Eon Park, Sung Tae Kim, Jong Min Lee, Sue J. Kang, Mee Kyung Suh, Juhee Chin, Duk L. Na, Dae Ryong Kang, Sang Won Seo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Epidemiological studies have reported that higher education (HE) is associated with a reduced risk of incident Alzheimer's disease (AD). However, after the clinical onset of AD, patients with HE levels show more rapid cognitive decline than patients with lower education (LE) levels. Although education level and cognition have been linked, there have been few longitudinal studies investigating the relationship between education level and cortical decline in patients with AD. The aim of this study was to compare the topography of cortical atrophy longitudinally between AD patients with HE (HE-AD) and AD patients with LE (LE-AD). Methods: We prospectively recruited 36 patients with early-stage AD and 14 normal controls. The patients were classified into two groups according to educational level, 23 HE-AD (>9 years) and 13 LE-AD (≤9 years). Results: As AD progressed over the 5-year longitudinal follow-ups, the HE-AD showed a significant group-by-time interaction in the right dorsolateral frontal and precuneus, and the left parahippocampal regions compared to the LE-AD. Conclusion: Our study reveals that the preliminary longitudinal effect of HE accelerates cortical atrophy in AD patients over time, which underlines the importance of education level for predicting prognosis.

Original languageEnglish
Pages (from-to)111-120
Number of pages10
JournalInternational Psychogeriatrics
Volume27
Issue number1
DOIs
Publication statusPublished - 2015 Jan 12

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Longitudinal Studies
Education
Alzheimer Disease
Alzheimer Disease 5
Atrophy
Parietal Lobe
Cognition
Epidemiologic Studies

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Cho, Hanna ; Jeon, Seun ; Kim, Changsoo ; Ye, Byoung Seok ; Kim, Geon Ha ; Noh, Young ; Kim, Hee Jin ; Yoon, Cindy W. ; Kim, Yeo Jin ; Kim, Jung Hyun ; Park, Sang Eon ; Kim, Sung Tae ; Lee, Jong Min ; Kang, Sue J. ; Suh, Mee Kyung ; Chin, Juhee ; Na, Duk L. ; Kang, Dae Ryong ; Seo, Sang Won. / Higher education affects accelerated cortical thinning in Alzheimer's disease : A 5-year preliminary longitudinal study. In: International Psychogeriatrics. 2015 ; Vol. 27, No. 1. pp. 111-120.
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title = "Higher education affects accelerated cortical thinning in Alzheimer's disease: A 5-year preliminary longitudinal study",
abstract = "Background: Epidemiological studies have reported that higher education (HE) is associated with a reduced risk of incident Alzheimer's disease (AD). However, after the clinical onset of AD, patients with HE levels show more rapid cognitive decline than patients with lower education (LE) levels. Although education level and cognition have been linked, there have been few longitudinal studies investigating the relationship between education level and cortical decline in patients with AD. The aim of this study was to compare the topography of cortical atrophy longitudinally between AD patients with HE (HE-AD) and AD patients with LE (LE-AD). Methods: We prospectively recruited 36 patients with early-stage AD and 14 normal controls. The patients were classified into two groups according to educational level, 23 HE-AD (>9 years) and 13 LE-AD (≤9 years). Results: As AD progressed over the 5-year longitudinal follow-ups, the HE-AD showed a significant group-by-time interaction in the right dorsolateral frontal and precuneus, and the left parahippocampal regions compared to the LE-AD. Conclusion: Our study reveals that the preliminary longitudinal effect of HE accelerates cortical atrophy in AD patients over time, which underlines the importance of education level for predicting prognosis.",
author = "Hanna Cho and Seun Jeon and Changsoo Kim and Ye, {Byoung Seok} and Kim, {Geon Ha} and Young Noh and Kim, {Hee Jin} and Yoon, {Cindy W.} and Kim, {Yeo Jin} and Kim, {Jung Hyun} and Park, {Sang Eon} and Kim, {Sung Tae} and Lee, {Jong Min} and Kang, {Sue J.} and Suh, {Mee Kyung} and Juhee Chin and Na, {Duk L.} and Kang, {Dae Ryong} and Seo, {Sang Won}",
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Cho, H, Jeon, S, Kim, C, Ye, BS, Kim, GH, Noh, Y, Kim, HJ, Yoon, CW, Kim, YJ, Kim, JH, Park, SE, Kim, ST, Lee, JM, Kang, SJ, Suh, MK, Chin, J, Na, DL, Kang, DR & Seo, SW 2015, 'Higher education affects accelerated cortical thinning in Alzheimer's disease: A 5-year preliminary longitudinal study', International Psychogeriatrics, vol. 27, no. 1, pp. 111-120. https://doi.org/10.1017/S1041610214001483

Higher education affects accelerated cortical thinning in Alzheimer's disease : A 5-year preliminary longitudinal study. / Cho, Hanna; Jeon, Seun; Kim, Changsoo; Ye, Byoung Seok; Kim, Geon Ha; Noh, Young; Kim, Hee Jin; Yoon, Cindy W.; Kim, Yeo Jin; Kim, Jung Hyun; Park, Sang Eon; Kim, Sung Tae; Lee, Jong Min; Kang, Sue J.; Suh, Mee Kyung; Chin, Juhee; Na, Duk L.; Kang, Dae Ryong; Seo, Sang Won.

In: International Psychogeriatrics, Vol. 27, No. 1, 12.01.2015, p. 111-120.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Higher education affects accelerated cortical thinning in Alzheimer's disease

T2 - A 5-year preliminary longitudinal study

AU - Cho, Hanna

AU - Jeon, Seun

AU - Kim, Changsoo

AU - Ye, Byoung Seok

AU - Kim, Geon Ha

AU - Noh, Young

AU - Kim, Hee Jin

AU - Yoon, Cindy W.

AU - Kim, Yeo Jin

AU - Kim, Jung Hyun

AU - Park, Sang Eon

AU - Kim, Sung Tae

AU - Lee, Jong Min

AU - Kang, Sue J.

AU - Suh, Mee Kyung

AU - Chin, Juhee

AU - Na, Duk L.

AU - Kang, Dae Ryong

AU - Seo, Sang Won

PY - 2015/1/12

Y1 - 2015/1/12

N2 - Background: Epidemiological studies have reported that higher education (HE) is associated with a reduced risk of incident Alzheimer's disease (AD). However, after the clinical onset of AD, patients with HE levels show more rapid cognitive decline than patients with lower education (LE) levels. Although education level and cognition have been linked, there have been few longitudinal studies investigating the relationship between education level and cortical decline in patients with AD. The aim of this study was to compare the topography of cortical atrophy longitudinally between AD patients with HE (HE-AD) and AD patients with LE (LE-AD). Methods: We prospectively recruited 36 patients with early-stage AD and 14 normal controls. The patients were classified into two groups according to educational level, 23 HE-AD (>9 years) and 13 LE-AD (≤9 years). Results: As AD progressed over the 5-year longitudinal follow-ups, the HE-AD showed a significant group-by-time interaction in the right dorsolateral frontal and precuneus, and the left parahippocampal regions compared to the LE-AD. Conclusion: Our study reveals that the preliminary longitudinal effect of HE accelerates cortical atrophy in AD patients over time, which underlines the importance of education level for predicting prognosis.

AB - Background: Epidemiological studies have reported that higher education (HE) is associated with a reduced risk of incident Alzheimer's disease (AD). However, after the clinical onset of AD, patients with HE levels show more rapid cognitive decline than patients with lower education (LE) levels. Although education level and cognition have been linked, there have been few longitudinal studies investigating the relationship between education level and cortical decline in patients with AD. The aim of this study was to compare the topography of cortical atrophy longitudinally between AD patients with HE (HE-AD) and AD patients with LE (LE-AD). Methods: We prospectively recruited 36 patients with early-stage AD and 14 normal controls. The patients were classified into two groups according to educational level, 23 HE-AD (>9 years) and 13 LE-AD (≤9 years). Results: As AD progressed over the 5-year longitudinal follow-ups, the HE-AD showed a significant group-by-time interaction in the right dorsolateral frontal and precuneus, and the left parahippocampal regions compared to the LE-AD. Conclusion: Our study reveals that the preliminary longitudinal effect of HE accelerates cortical atrophy in AD patients over time, which underlines the importance of education level for predicting prognosis.

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