Highly efficient single cell capturing in microwell array using hydrodynamic guiding structures

Jaehoon Chung, Young Ji Kim, Il Joo Cho, Euisik Yoon

Research output: Contribution to conferencePaperpeer-review

1 Citation (Scopus)

Abstract

This paper presents a microfluidic chip array for high-throughput single cell assay with an efficient cell capture rate. The single cell capture structure utilizes hydrodynamic resistance difference in flow paths and its feasibility was tested. More than 40% of all the injected microbeads were captured in the designated capture sites. The capture structure was expanded in an array of microwells formed at the intersection of rows and columns of orthogonal microchannels. By selectively operating integrated pneumatic valves, we successfully demonstrated cell seeding, reagents injection and cell isolation without cross-contamination.

Original languageEnglish
Pages477-479
Number of pages3
Publication statusPublished - 2008
Event12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States
Duration: 2008 Oct 122008 Oct 16

Other

Other12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
CountryUnited States
CitySan Diego, CA
Period08/10/1208/10/16

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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