Highly luminescent biocompatible CsPbBr3@SiO2core-shell nanoprobes for bioimaging and drug delivery

Pawan Kumar, Madhumita Patel, Chanho Park, Hyowon Han, Beomjin Jeong, Hansol Kang, Rajkumar Patel, Won Gun Koh, Cheolmin Park

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The encapsulation of lead halide perovskite nanocrystals (PNCs) with an inert protective layer against moisture and the environment is a promising approach to overcome hinderances for their practical use in optoelectronic and biomedical applications. Herein, a facile method for synthesizing highly luminescent and biocompatible CsPbBr3@SiO2 core-shell PNCs with a controlled SiO2 thickness, which are suitable for both cell imaging and drug delivery, is reported. The synthesized CsPbBr3@SiO2 core-shell PNCs exhibit bright green emission at 518 nm upon excitation of 374 nm. Interestingly, a significant increase in the photoluminescence intensity is observed with an increase in the SiO2 shell thickness, which varies with the increasing reaction time. Cytotoxicity results indicate that the CsPbBr3@SiO2 core-shell PNCs are nontoxic, making them suitable for in vitro cell imaging using HeLa cells. Furthermore, doxorubicin physically adsorbed on the surface of CsPbBr3@SiO2 core-shell PNCs is efficiently released in cells when the drug-loaded perovskite nanoprobes are injected in the cells, indicating that these core-shell nanoparticles can be used for drug loading and delivery. The results of this study suggest that the CsPbBr3@SiO2 core-shell PNCs can pave the way for new biomedical applications and processes. This journal is

Original languageEnglish
Pages (from-to)10337-10345
Number of pages9
JournalJournal of Materials Chemistry B
Volume8
Issue number45
DOIs
Publication statusPublished - 2020 Dec 7

Bibliographical note

Funding Information:
This research was supported by the Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2018M3D1A1058536 and 2017M3A7B4041798). This research was also supported by a grant from the National Research Foundation of Korea (NRF) funded by the Korean government (MEST) (No. 2020R1A2B5B0300269711) and the Global PhD Fellowship Program funded by the Ministry of Education (NRF-2018H1A2A1062353).

Publisher Copyright:
© The Royal Society of Chemistry.

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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