Highly luminescent biocompatible CsPbBr3@SiO2core-shell nanoprobes for bioimaging and drug delivery

Pawan Kumar, Madhumita Patel, Chanho Park, Hyowon Han, Beomjin Jeong, Hansol Kang, Rajkumar Patel, Won Gun Koh, Cheolmin Park

Research output: Contribution to journalArticlepeer-review

Abstract

The encapsulation of lead halide perovskite nanocrystals (PNCs) with an inert protective layer against moisture and the environment is a promising approach to overcome hinderances for their practical use in optoelectronic and biomedical applications. Herein, a facile method for synthesizing highly luminescent and biocompatible CsPbBr3@SiO2 core-shell PNCs with a controlled SiO2 thickness, which are suitable for both cell imaging and drug delivery, is reported. The synthesized CsPbBr3@SiO2 core-shell PNCs exhibit bright green emission at 518 nm upon excitation of 374 nm. Interestingly, a significant increase in the photoluminescence intensity is observed with an increase in the SiO2 shell thickness, which varies with the increasing reaction time. Cytotoxicity results indicate that the CsPbBr3@SiO2 core-shell PNCs are nontoxic, making them suitable for in vitro cell imaging using HeLa cells. Furthermore, doxorubicin physically adsorbed on the surface of CsPbBr3@SiO2 core-shell PNCs is efficiently released in cells when the drug-loaded perovskite nanoprobes are injected in the cells, indicating that these core-shell nanoparticles can be used for drug loading and delivery. The results of this study suggest that the CsPbBr3@SiO2 core-shell PNCs can pave the way for new biomedical applications and processes. This journal is

Original languageEnglish
Pages (from-to)10337-10345
Number of pages9
JournalJournal of Materials Chemistry B
Volume8
Issue number45
DOIs
Publication statusPublished - 2020 Dec 7

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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