Highly selective CD44-specific gold nanorods for photothermal ablation of tumorigenic subpopulations generated in MCF7 mammospheres

Eugene Lee; Yoochan Hong; Jihye Choi; Seungjoo Haam; Jin Suck Suh; Yong Min Huh; Jaemoon Yang

doi:10.1088/0957-4484/23/46/465101

Highly selective CD44-specific gold nanorods for photothermal ablation of tumorigenic subpopulations generated in MCF7 mammospheres

Eugene Lee, Yoochan Hong, Jihye Choi, Seungjoo Haam, Jin Suck Suh, Yong Min Huh, Jaemoon Yang

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Heterogeneous stem-like populations within tumor tissues are the primary suspects in causing cancer recurrence and malignancy. It is essential to selectively kill these tumorigenic populations. We created a novel system for photothermally ablating specific cells from three-dimensional mammospheres. A CD44-positive subpopulation, with tumorigenic and self-renewal potential, spontaneously arises in MCF7 breast cancer cell-engineered mammospheres. Using anti-CD44 antibody-linked gold nanorods, which strongly absorb near infrared light and increase local temperature, we effectively targeted and photo-ablated atypical cells. This biomarker-specific photothermal ablation model, using a smart nanoplatform, is a promising new strategy for selectively killing cancer cells, while sparing normal tissues.

Original language	English
Article number	465101
Journal	Nanotechnology
Volume	23
Issue number	46
DOIs	https://doi.org/10.1088/0957-4484/23/46/465101
Publication status	Published - 2012 Nov 23

All Science Journal Classification (ASJC) codes

Bioengineering
Chemistry(all)
Materials Science(all)
Mechanics of Materials
Mechanical Engineering
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

Access to Document

10.1088/0957-4484/23/46/465101

Fingerprint Dive into the research topics of 'Highly selective CD44-specific gold nanorods for photothermal ablation of tumorigenic subpopulations generated in MCF7 mammospheres'. Together they form a unique fingerprint.

Cite this

@article{d0221c6a93dd456b9d5f23f1e4912222,

title = "Highly selective CD44-specific gold nanorods for photothermal ablation of tumorigenic subpopulations generated in MCF7 mammospheres",

abstract = "Heterogeneous stem-like populations within tumor tissues are the primary suspects in causing cancer recurrence and malignancy. It is essential to selectively kill these tumorigenic populations. We created a novel system for photothermally ablating specific cells from three-dimensional mammospheres. A CD44-positive subpopulation, with tumorigenic and self-renewal potential, spontaneously arises in MCF7 breast cancer cell-engineered mammospheres. Using anti-CD44 antibody-linked gold nanorods, which strongly absorb near infrared light and increase local temperature, we effectively targeted and photo-ablated atypical cells. This biomarker-specific photothermal ablation model, using a smart nanoplatform, is a promising new strategy for selectively killing cancer cells, while sparing normal tissues.",

author = "Eugene Lee and Yoochan Hong and Jihye Choi and Seungjoo Haam and Suh, {Jin Suck} and Huh, {Yong Min} and Jaemoon Yang",

year = "2012",

month = nov,

day = "23",

doi = "10.1088/0957-4484/23/46/465101",

language = "English",

volume = "23",

journal = "Nanotechnology",

issn = "0957-4484",

publisher = "IOP Publishing Ltd.",

number = "46",

}

TY - JOUR

T1 - Highly selective CD44-specific gold nanorods for photothermal ablation of tumorigenic subpopulations generated in MCF7 mammospheres

AU - Lee, Eugene

AU - Hong, Yoochan

AU - Choi, Jihye

AU - Haam, Seungjoo

AU - Suh, Jin Suck

AU - Huh, Yong Min

AU - Yang, Jaemoon

PY - 2012/11/23

Y1 - 2012/11/23

N2 - Heterogeneous stem-like populations within tumor tissues are the primary suspects in causing cancer recurrence and malignancy. It is essential to selectively kill these tumorigenic populations. We created a novel system for photothermally ablating specific cells from three-dimensional mammospheres. A CD44-positive subpopulation, with tumorigenic and self-renewal potential, spontaneously arises in MCF7 breast cancer cell-engineered mammospheres. Using anti-CD44 antibody-linked gold nanorods, which strongly absorb near infrared light and increase local temperature, we effectively targeted and photo-ablated atypical cells. This biomarker-specific photothermal ablation model, using a smart nanoplatform, is a promising new strategy for selectively killing cancer cells, while sparing normal tissues.

AB - Heterogeneous stem-like populations within tumor tissues are the primary suspects in causing cancer recurrence and malignancy. It is essential to selectively kill these tumorigenic populations. We created a novel system for photothermally ablating specific cells from three-dimensional mammospheres. A CD44-positive subpopulation, with tumorigenic and self-renewal potential, spontaneously arises in MCF7 breast cancer cell-engineered mammospheres. Using anti-CD44 antibody-linked gold nanorods, which strongly absorb near infrared light and increase local temperature, we effectively targeted and photo-ablated atypical cells. This biomarker-specific photothermal ablation model, using a smart nanoplatform, is a promising new strategy for selectively killing cancer cells, while sparing normal tissues.

UR - http://www.scopus.com/inward/record.url?scp=84867934142&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867934142&partnerID=8YFLogxK

U2 - 10.1088/0957-4484/23/46/465101

DO - 10.1088/0957-4484/23/46/465101

M3 - Article

C2 - 23093111

AN - SCOPUS:84867934142

VL - 23

JO - Nanotechnology

JF - Nanotechnology

SN - 0957-4484

IS - 46

M1 - 465101

ER -

Highly selective CD44-specific gold nanorods for photothermal ablation of tumorigenic subpopulations generated in MCF7 mammospheres

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Cite this