Highly selective CD44-specific gold nanorods for photothermal ablation of tumorigenic subpopulations generated in MCF7 mammospheres

Eugene Lee, Yoochan Hong, Jihye Choi, Seungjoo Haam, Jinsuck Suh, yongmin Huh, Jaemoon Yang

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Heterogeneous stem-like populations within tumor tissues are the primary suspects in causing cancer recurrence and malignancy. It is essential to selectively kill these tumorigenic populations. We created a novel system for photothermally ablating specific cells from three-dimensional mammospheres. A CD44-positive subpopulation, with tumorigenic and self-renewal potential, spontaneously arises in MCF7 breast cancer cell-engineered mammospheres. Using anti-CD44 antibody-linked gold nanorods, which strongly absorb near infrared light and increase local temperature, we effectively targeted and photo-ablated atypical cells. This biomarker-specific photothermal ablation model, using a smart nanoplatform, is a promising new strategy for selectively killing cancer cells, while sparing normal tissues.

Original languageEnglish
Article number465101
JournalNanotechnology
Volume23
Issue number46
DOIs
Publication statusPublished - 2012 Nov 23

Fingerprint

Ablation
Nanorods
Gold
Cells
Tissue
Biomarkers
Antibodies
Tumors
Infrared radiation
Temperature

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Cite this

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Highly selective CD44-specific gold nanorods for photothermal ablation of tumorigenic subpopulations generated in MCF7 mammospheres. / Lee, Eugene; Hong, Yoochan; Choi, Jihye; Haam, Seungjoo; Suh, Jinsuck; Huh, yongmin; Yang, Jaemoon.

In: Nanotechnology, Vol. 23, No. 46, 465101, 23.11.2012.

Research output: Contribution to journalArticle

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AU - Lee, Eugene

AU - Hong, Yoochan

AU - Choi, Jihye

AU - Haam, Seungjoo

AU - Suh, Jinsuck

AU - Huh, yongmin

AU - Yang, Jaemoon

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