Abstract
Heterogeneous stem-like populations within tumor tissues are the primary suspects in causing cancer recurrence and malignancy. It is essential to selectively kill these tumorigenic populations. We created a novel system for photothermally ablating specific cells from three-dimensional mammospheres. A CD44-positive subpopulation, with tumorigenic and self-renewal potential, spontaneously arises in MCF7 breast cancer cell-engineered mammospheres. Using anti-CD44 antibody-linked gold nanorods, which strongly absorb near infrared light and increase local temperature, we effectively targeted and photo-ablated atypical cells. This biomarker-specific photothermal ablation model, using a smart nanoplatform, is a promising new strategy for selectively killing cancer cells, while sparing normal tissues.
| Original language | English |
|---|---|
| Article number | 465101 |
| Journal | Nanotechnology |
| Volume | 23 |
| Issue number | 46 |
| DOIs | |
| Publication status | Published - 2012 Nov 23 |
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All Science Journal Classification (ASJC) codes
- Bioengineering
- Chemistry(all)
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering
- Electrical and Electronic Engineering
Cite this
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Highly selective CD44-specific gold nanorods for photothermal ablation of tumorigenic subpopulations generated in MCF7 mammospheres. / Lee, Eugene; Hong, Yoochan; Choi, Jihye; Haam, Seungjoo; Suh, Jinsuck; Huh, yongmin; Yang, Jaemoon.
In: Nanotechnology, Vol. 23, No. 46, 465101, 23.11.2012.Research output: Contribution to journal › Article
TY - JOUR
T1 - Highly selective CD44-specific gold nanorods for photothermal ablation of tumorigenic subpopulations generated in MCF7 mammospheres
AU - Lee, Eugene
AU - Hong, Yoochan
AU - Choi, Jihye
AU - Haam, Seungjoo
AU - Suh, Jinsuck
AU - Huh, yongmin
AU - Yang, Jaemoon
PY - 2012/11/23
Y1 - 2012/11/23
N2 - Heterogeneous stem-like populations within tumor tissues are the primary suspects in causing cancer recurrence and malignancy. It is essential to selectively kill these tumorigenic populations. We created a novel system for photothermally ablating specific cells from three-dimensional mammospheres. A CD44-positive subpopulation, with tumorigenic and self-renewal potential, spontaneously arises in MCF7 breast cancer cell-engineered mammospheres. Using anti-CD44 antibody-linked gold nanorods, which strongly absorb near infrared light and increase local temperature, we effectively targeted and photo-ablated atypical cells. This biomarker-specific photothermal ablation model, using a smart nanoplatform, is a promising new strategy for selectively killing cancer cells, while sparing normal tissues.
AB - Heterogeneous stem-like populations within tumor tissues are the primary suspects in causing cancer recurrence and malignancy. It is essential to selectively kill these tumorigenic populations. We created a novel system for photothermally ablating specific cells from three-dimensional mammospheres. A CD44-positive subpopulation, with tumorigenic and self-renewal potential, spontaneously arises in MCF7 breast cancer cell-engineered mammospheres. Using anti-CD44 antibody-linked gold nanorods, which strongly absorb near infrared light and increase local temperature, we effectively targeted and photo-ablated atypical cells. This biomarker-specific photothermal ablation model, using a smart nanoplatform, is a promising new strategy for selectively killing cancer cells, while sparing normal tissues.
UR - http://www.scopus.com/inward/record.url?scp=84867934142&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867934142&partnerID=8YFLogxK
U2 - 10.1088/0957-4484/23/46/465101
DO - 10.1088/0957-4484/23/46/465101
M3 - Article
VL - 23
JO - Nanotechnology
JF - Nanotechnology
SN - 0957-4484
IS - 46
M1 - 465101
ER -