In recent years when the demand for high-performance biosensors has been aroused, a field-effect transistor (FET)-type biosensor (BioFET) has attracted great interest because of its high sensitivity, label-free detection, fast detection speed, and miniaturization. However, the insulating membrane in the conventional BioFET, which is essential in preventing the surface dangling bonds of typical semiconductors from nonspecific bindings, has limited the sensitivity of biosensors. Here, we present a highly sensitive and reusable membraneless BioFET based on a defect-free van der Waals material, tungsten diselenide (WSe2). We intentionally generated a few surface defects that serve as extra binding sites for the bioreceptor immobilization through weak oxygen plasma treatment, consequently magnifying the sensitivity values to 2.87 × 105 A/A for 10 mM glucose. The WSe2 BioFET also maintained its high sensitivity even after several cycles of rinsing and glucose application were repeated.
Bibliographical noteFunding Information:
This research was supported by grants from the Gyeonggi Technology Development Program funded by Gyeonggi Province (no. 2016BB008), the Basic Research Lab Program and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Korea Government (MSIP) (nos. 2018R1A2A2A05020475, 2017R1A4A1015400, and 2015M3A7B7045496), and the Future Semiconductor Device Technology Development Program (10067739) funded by the Ministry of Trade, Industry & Energy (MOTIE) and the Korea Semiconductor Research Consortium (KSRC).
All Science Journal Classification (ASJC) codes
- Materials Science(all)