Highly stable nanocontainer of APTES-anchored layered titanate nanosheet for reliable protection/recovery of nucleic acid

Tae Woo Kim, In Young Kim, Dae Hwan Park, Jin Ho Choy, Seong Ju Hwang

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

A universal technology for the encapsulative protection of unstable anionic species by highly stable layered metal oxide has been developed via the surface modification of a metal oxide nanosheet. The surface anchoring of (3-aminopropyl)triethoxysilane (APTES) on exfoliated titanate nanosheet yields a novel cationic metal oxide nanosheet, which can be universally used for the hybridization with various biological and inorganic anions. The encapsulation of deoxyribonucleic acid (DNA) in the cationic APTES-anchored titanate lattice makes possible the reliable long-term protection of DNA against enzymatic, chemical, and UVâ 'vis light corrosions. The encapsulated DNA can be easily released from the titanate lattice via sonication, underscoring the functionality of the cationic APTES-anchored titanate nanosheet as a stable nanocontainer for DNA. The APTES-anchored titanate nanosheet can be also used as an efficient CO 2 adsorbent and a versatile host material for various inorganic anions like polyoxometalates, leading to the synthesis of novel intercalative nanohybrids with unexplored properties and useful functionalities.

Original languageEnglish
Article number21993
JournalScientific reports
Volume6
DOIs
Publication statusPublished - 2016 Feb 24

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. NRF-2014R1A2A1A10052809) and by the Global Frontier R&D Program (2013-073298) on Center for Hybrid Interface Materials (HIM). The experiments at PAL were supported in part by MOST and POSTECH.

All Science Journal Classification (ASJC) codes

  • General

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