Hinman syndrome: Long term follow up of 14 cases

Dong Hoon Lee, Yong Soo Kim, Hye Young Lee, Sang Won Han

Research output: Contribution to journalArticle

Abstract

Purpose: Hinman syndrome is the most severe form of nonneurogenic neurogenic bladder causing damage of the upper urinary tract. Fourteen patients with Hinman syndrome followed at our institution were evaluated for their clinical characteristics and prognosis. Here we report the findings of this series of patients for this poorly understood syndrome. Materials and Methods: The medical records of 14 patients, 8 boys and 6 girls, diagnosed with Hinman syndrome from March 1993 to June 2006 were reviewed. The mean duration of follow up was 69 months. The ultrasonography, 99m Tc-dimercaptosuccinic acid renal scan (DMSA), voiding cystourethrogram (VCUG), and urodynamic study (UDS) results were retrospectively analyzed and efficacy of each treatment method was evaluated based on the medical records on follow up. Results: Hydronephrosis of grade III or greater on ultrasonography and renal scarring of both kidneys on the DMSA renal scan were observed in 12 and 14 patients, respectively. Severe bladder trabeculation and high grade VUR (IV, V) were observed on the VCUG in 14 and 8 patients, respectively. Decreased bladder compliance on the UDS was noted in 13 and detrussor-sphincter dyssynergia (DSD) was observed in eight. Medical treatment was not effective in all 14 cases and six patients who underwent botulinum injection of the bladder were unresponsive to that treatment as well. In spite of conservative treatments such as clean intermittent catheterization (CIC), seven patients eventually underwent bladder augmentations after a mean period of thirty-seven months from diagnosis because of concern about the loss of bladder capacity and renal function. One patient who did not perform CIC progressed to end-stage renal disease and had to be transferred to pediatric nephrology for dialysis. Conclusions: Patients diagnosed with the Hinman syndrome were treated similar to patients with neurogenic bladder. However, from the longterm follow up data at our outpatient clinic, many patients eventually had bladder augmentation to prevent further loss of bladder capacity and renal function. Therefore, urologists must not hesitate in performing such treatment when necessary.

Original languageEnglish
Pages (from-to)1058-1063
Number of pages6
JournalKorean Journal of Urology
Volume48
Issue number10
DOIs
Publication statusPublished - 2007 Oct

Fingerprint

Urinary Bladder
Kidney
Intermittent Urethral Catheterization
Succimer
Neurogenic Urinary Bladder
Urodynamics
Medical Records
Ultrasonography
Technetium Tc 99m Dimercaptosuccinic Acid
Nephrology
Hydronephrosis
Ataxia
Ambulatory Care Facilities
Urinary Tract
Compliance
Chronic Kidney Failure
Cicatrix
Dialysis
Therapeutics
Pediatrics

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Lee, Dong Hoon ; Kim, Yong Soo ; Lee, Hye Young ; Han, Sang Won. / Hinman syndrome : Long term follow up of 14 cases. In: Korean Journal of Urology. 2007 ; Vol. 48, No. 10. pp. 1058-1063.
@article{bcb51c25abc1489a8cb599030500ad30,
title = "Hinman syndrome: Long term follow up of 14 cases",
abstract = "Purpose: Hinman syndrome is the most severe form of nonneurogenic neurogenic bladder causing damage of the upper urinary tract. Fourteen patients with Hinman syndrome followed at our institution were evaluated for their clinical characteristics and prognosis. Here we report the findings of this series of patients for this poorly understood syndrome. Materials and Methods: The medical records of 14 patients, 8 boys and 6 girls, diagnosed with Hinman syndrome from March 1993 to June 2006 were reviewed. The mean duration of follow up was 69 months. The ultrasonography, 99m Tc-dimercaptosuccinic acid renal scan (DMSA), voiding cystourethrogram (VCUG), and urodynamic study (UDS) results were retrospectively analyzed and efficacy of each treatment method was evaluated based on the medical records on follow up. Results: Hydronephrosis of grade III or greater on ultrasonography and renal scarring of both kidneys on the DMSA renal scan were observed in 12 and 14 patients, respectively. Severe bladder trabeculation and high grade VUR (IV, V) were observed on the VCUG in 14 and 8 patients, respectively. Decreased bladder compliance on the UDS was noted in 13 and detrussor-sphincter dyssynergia (DSD) was observed in eight. Medical treatment was not effective in all 14 cases and six patients who underwent botulinum injection of the bladder were unresponsive to that treatment as well. In spite of conservative treatments such as clean intermittent catheterization (CIC), seven patients eventually underwent bladder augmentations after a mean period of thirty-seven months from diagnosis because of concern about the loss of bladder capacity and renal function. One patient who did not perform CIC progressed to end-stage renal disease and had to be transferred to pediatric nephrology for dialysis. Conclusions: Patients diagnosed with the Hinman syndrome were treated similar to patients with neurogenic bladder. However, from the longterm follow up data at our outpatient clinic, many patients eventually had bladder augmentation to prevent further loss of bladder capacity and renal function. Therefore, urologists must not hesitate in performing such treatment when necessary.",
author = "Lee, {Dong Hoon} and Kim, {Yong Soo} and Lee, {Hye Young} and Han, {Sang Won}",
year = "2007",
month = "10",
doi = "10.4111/kju.2007.48.10.1058",
language = "English",
volume = "48",
pages = "1058--1063",
journal = "Korean Journal of Urology",
issn = "2005-6737",
publisher = "Korean Urological Association",
number = "10",

}

Hinman syndrome : Long term follow up of 14 cases. / Lee, Dong Hoon; Kim, Yong Soo; Lee, Hye Young; Han, Sang Won.

In: Korean Journal of Urology, Vol. 48, No. 10, 10.2007, p. 1058-1063.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hinman syndrome

T2 - Long term follow up of 14 cases

AU - Lee, Dong Hoon

AU - Kim, Yong Soo

AU - Lee, Hye Young

AU - Han, Sang Won

PY - 2007/10

Y1 - 2007/10

N2 - Purpose: Hinman syndrome is the most severe form of nonneurogenic neurogenic bladder causing damage of the upper urinary tract. Fourteen patients with Hinman syndrome followed at our institution were evaluated for their clinical characteristics and prognosis. Here we report the findings of this series of patients for this poorly understood syndrome. Materials and Methods: The medical records of 14 patients, 8 boys and 6 girls, diagnosed with Hinman syndrome from March 1993 to June 2006 were reviewed. The mean duration of follow up was 69 months. The ultrasonography, 99m Tc-dimercaptosuccinic acid renal scan (DMSA), voiding cystourethrogram (VCUG), and urodynamic study (UDS) results were retrospectively analyzed and efficacy of each treatment method was evaluated based on the medical records on follow up. Results: Hydronephrosis of grade III or greater on ultrasonography and renal scarring of both kidneys on the DMSA renal scan were observed in 12 and 14 patients, respectively. Severe bladder trabeculation and high grade VUR (IV, V) were observed on the VCUG in 14 and 8 patients, respectively. Decreased bladder compliance on the UDS was noted in 13 and detrussor-sphincter dyssynergia (DSD) was observed in eight. Medical treatment was not effective in all 14 cases and six patients who underwent botulinum injection of the bladder were unresponsive to that treatment as well. In spite of conservative treatments such as clean intermittent catheterization (CIC), seven patients eventually underwent bladder augmentations after a mean period of thirty-seven months from diagnosis because of concern about the loss of bladder capacity and renal function. One patient who did not perform CIC progressed to end-stage renal disease and had to be transferred to pediatric nephrology for dialysis. Conclusions: Patients diagnosed with the Hinman syndrome were treated similar to patients with neurogenic bladder. However, from the longterm follow up data at our outpatient clinic, many patients eventually had bladder augmentation to prevent further loss of bladder capacity and renal function. Therefore, urologists must not hesitate in performing such treatment when necessary.

AB - Purpose: Hinman syndrome is the most severe form of nonneurogenic neurogenic bladder causing damage of the upper urinary tract. Fourteen patients with Hinman syndrome followed at our institution were evaluated for their clinical characteristics and prognosis. Here we report the findings of this series of patients for this poorly understood syndrome. Materials and Methods: The medical records of 14 patients, 8 boys and 6 girls, diagnosed with Hinman syndrome from March 1993 to June 2006 were reviewed. The mean duration of follow up was 69 months. The ultrasonography, 99m Tc-dimercaptosuccinic acid renal scan (DMSA), voiding cystourethrogram (VCUG), and urodynamic study (UDS) results were retrospectively analyzed and efficacy of each treatment method was evaluated based on the medical records on follow up. Results: Hydronephrosis of grade III or greater on ultrasonography and renal scarring of both kidneys on the DMSA renal scan were observed in 12 and 14 patients, respectively. Severe bladder trabeculation and high grade VUR (IV, V) were observed on the VCUG in 14 and 8 patients, respectively. Decreased bladder compliance on the UDS was noted in 13 and detrussor-sphincter dyssynergia (DSD) was observed in eight. Medical treatment was not effective in all 14 cases and six patients who underwent botulinum injection of the bladder were unresponsive to that treatment as well. In spite of conservative treatments such as clean intermittent catheterization (CIC), seven patients eventually underwent bladder augmentations after a mean period of thirty-seven months from diagnosis because of concern about the loss of bladder capacity and renal function. One patient who did not perform CIC progressed to end-stage renal disease and had to be transferred to pediatric nephrology for dialysis. Conclusions: Patients diagnosed with the Hinman syndrome were treated similar to patients with neurogenic bladder. However, from the longterm follow up data at our outpatient clinic, many patients eventually had bladder augmentation to prevent further loss of bladder capacity and renal function. Therefore, urologists must not hesitate in performing such treatment when necessary.

UR - http://www.scopus.com/inward/record.url?scp=35848939391&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35848939391&partnerID=8YFLogxK

U2 - 10.4111/kju.2007.48.10.1058

DO - 10.4111/kju.2007.48.10.1058

M3 - Article

AN - SCOPUS:35848939391

VL - 48

SP - 1058

EP - 1063

JO - Korean Journal of Urology

JF - Korean Journal of Urology

SN - 2005-6737

IS - 10

ER -