Hippocampal mGluR5 predicts an occurrence of helplessness behavior after repetitive exposure to uncontrollable stress

Yeong Shin Yim, Jinu Lee, Gun Tae Kim, Teresa Song, Chul Hoon Kim, Dong Goo Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

An individual's behavior is generally based on genetic blueprint and previous experiences. A coping strategy, affected by personal interpretation of past events, can be determined by behavioral controllability of stress. In this study, we examined the relationship between the hippocampal mGluR5 expression and coping strategies to stress. Rats were exposed to stress via inescapable and unpredictable footshocks on PNDs 14 and 90. Coping strategies to stress were also measured. Hippocampal mGluR5 was found to be linked to the behavioral coping strategy, as it increased in rats that showed helplessness behavior (HL (+) group) and decreased in those that did not (HL (-) group). Also, the HL (+) group showed a lack of adaptation in a novel environment but the HL (-) group did not. The results suggest that mGluR5 has a pivotal role in the controllability-based coping strategy. Hippocampal mGluR5 could be a target molecule in the manipulation of neuropsychiatric conditions for which maladaptation is a part of behavioral consequences.

Original languageEnglish
Pages (from-to)62-66
Number of pages5
JournalNeuroscience Letters
Volume519
Issue number1
DOIs
Publication statusPublished - 2012 Jun 21

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Yim, Yeong Shin ; Lee, Jinu ; Kim, Gun Tae ; Song, Teresa ; Kim, Chul Hoon ; Kim, Dong Goo. / Hippocampal mGluR5 predicts an occurrence of helplessness behavior after repetitive exposure to uncontrollable stress. In: Neuroscience Letters. 2012 ; Vol. 519, No. 1. pp. 62-66.
@article{0faac397c57e42c686470d8d2cfd6156,
title = "Hippocampal mGluR5 predicts an occurrence of helplessness behavior after repetitive exposure to uncontrollable stress",
abstract = "An individual's behavior is generally based on genetic blueprint and previous experiences. A coping strategy, affected by personal interpretation of past events, can be determined by behavioral controllability of stress. In this study, we examined the relationship between the hippocampal mGluR5 expression and coping strategies to stress. Rats were exposed to stress via inescapable and unpredictable footshocks on PNDs 14 and 90. Coping strategies to stress were also measured. Hippocampal mGluR5 was found to be linked to the behavioral coping strategy, as it increased in rats that showed helplessness behavior (HL (+) group) and decreased in those that did not (HL (-) group). Also, the HL (+) group showed a lack of adaptation in a novel environment but the HL (-) group did not. The results suggest that mGluR5 has a pivotal role in the controllability-based coping strategy. Hippocampal mGluR5 could be a target molecule in the manipulation of neuropsychiatric conditions for which maladaptation is a part of behavioral consequences.",
author = "Yim, {Yeong Shin} and Jinu Lee and Kim, {Gun Tae} and Teresa Song and Kim, {Chul Hoon} and Kim, {Dong Goo}",
year = "2012",
month = "6",
day = "21",
doi = "10.1016/j.neulet.2012.05.022",
language = "English",
volume = "519",
pages = "62--66",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

Hippocampal mGluR5 predicts an occurrence of helplessness behavior after repetitive exposure to uncontrollable stress. / Yim, Yeong Shin; Lee, Jinu; Kim, Gun Tae; Song, Teresa; Kim, Chul Hoon; Kim, Dong Goo.

In: Neuroscience Letters, Vol. 519, No. 1, 21.06.2012, p. 62-66.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hippocampal mGluR5 predicts an occurrence of helplessness behavior after repetitive exposure to uncontrollable stress

AU - Yim, Yeong Shin

AU - Lee, Jinu

AU - Kim, Gun Tae

AU - Song, Teresa

AU - Kim, Chul Hoon

AU - Kim, Dong Goo

PY - 2012/6/21

Y1 - 2012/6/21

N2 - An individual's behavior is generally based on genetic blueprint and previous experiences. A coping strategy, affected by personal interpretation of past events, can be determined by behavioral controllability of stress. In this study, we examined the relationship between the hippocampal mGluR5 expression and coping strategies to stress. Rats were exposed to stress via inescapable and unpredictable footshocks on PNDs 14 and 90. Coping strategies to stress were also measured. Hippocampal mGluR5 was found to be linked to the behavioral coping strategy, as it increased in rats that showed helplessness behavior (HL (+) group) and decreased in those that did not (HL (-) group). Also, the HL (+) group showed a lack of adaptation in a novel environment but the HL (-) group did not. The results suggest that mGluR5 has a pivotal role in the controllability-based coping strategy. Hippocampal mGluR5 could be a target molecule in the manipulation of neuropsychiatric conditions for which maladaptation is a part of behavioral consequences.

AB - An individual's behavior is generally based on genetic blueprint and previous experiences. A coping strategy, affected by personal interpretation of past events, can be determined by behavioral controllability of stress. In this study, we examined the relationship between the hippocampal mGluR5 expression and coping strategies to stress. Rats were exposed to stress via inescapable and unpredictable footshocks on PNDs 14 and 90. Coping strategies to stress were also measured. Hippocampal mGluR5 was found to be linked to the behavioral coping strategy, as it increased in rats that showed helplessness behavior (HL (+) group) and decreased in those that did not (HL (-) group). Also, the HL (+) group showed a lack of adaptation in a novel environment but the HL (-) group did not. The results suggest that mGluR5 has a pivotal role in the controllability-based coping strategy. Hippocampal mGluR5 could be a target molecule in the manipulation of neuropsychiatric conditions for which maladaptation is a part of behavioral consequences.

UR - http://www.scopus.com/inward/record.url?scp=84861835330&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861835330&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2012.05.022

DO - 10.1016/j.neulet.2012.05.022

M3 - Article

VL - 519

SP - 62

EP - 66

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -