Hippocampal mGluR5 predicts an occurrence of helplessness behavior after repetitive exposure to uncontrollable stress

Yeong Shin Yim, Jinu Lee, Gun Tae Kim, Teresa Song, Chul Hoon Kim, Dong Goo Kim

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8 Citations (Scopus)


An individual's behavior is generally based on genetic blueprint and previous experiences. A coping strategy, affected by personal interpretation of past events, can be determined by behavioral controllability of stress. In this study, we examined the relationship between the hippocampal mGluR5 expression and coping strategies to stress. Rats were exposed to stress via inescapable and unpredictable footshocks on PNDs 14 and 90. Coping strategies to stress were also measured. Hippocampal mGluR5 was found to be linked to the behavioral coping strategy, as it increased in rats that showed helplessness behavior (HL (+) group) and decreased in those that did not (HL (-) group). Also, the HL (+) group showed a lack of adaptation in a novel environment but the HL (-) group did not. The results suggest that mGluR5 has a pivotal role in the controllability-based coping strategy. Hippocampal mGluR5 could be a target molecule in the manipulation of neuropsychiatric conditions for which maladaptation is a part of behavioral consequences.

Original languageEnglish
Pages (from-to)62-66
Number of pages5
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 2012 Jun 21

Bibliographical note

Funding Information:
This study was supported by the Korea Research Foundation Grant funded by the Korean Government ( KRF-7-2008-0409 ).

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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