Hippocampal TERT Regulates Spatial Memory Formation through Modulation of Neural Development

Qi Gang Zhou, Meng Ying Liu, Han Woong Lee, Fuyuki Ishikawa, Sushil Devkota, Xin Ru Shen, Xin Jin, Hai Yin Wu, Zhigang Liu, Xiao Liu, Xun Jin, Hai Hui Zhou, Eun Jeoung Ro, Jing Zhang, Yu Zhang, Yu Hui Lin, Hoonkyo Suh, Dong Ya Zhu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The molecular mechanism of memory formation remains a mystery. Here, we show that TERT, the catalytic subunit of telomerase, gene knockout (Tert −/− ) causes extremely poor ability in spatial memory formation. Knockdown of TERT in the dentate gyrus of adult hippocampus impairs spatial memory processes, while overexpression facilitates it. We find that TERT plays a critical role in neural development including dendritic development and neuritogenesis of hippocampal newborn neurons. A monosynaptic pseudotyped rabies virus retrograde tracing method shows that TERT is required for neural circuit integration of hippocampal newborn neurons. Interestingly, TERT regulated neural development and spatial memory formation in a reverse transcription activity-independent manner. Using X-ray irradiation, we find that hippocampal newborn neurons mediate the modulation of spatial memory processes by TERT. These observations reveal an important function of TERT through a non-canonical pathway and encourage the development of a TERT-based strategy to treat neurological disease-associated memory impairment.

Original languageEnglish
Pages (from-to)543-556
Number of pages14
JournalStem Cell Reports
Volume9
Issue number2
DOIs
Publication statusPublished - 2017 Aug 8

Fingerprint

Modulation
Data storage equipment
Neurons
Rabies virus
Parahippocampal Gyrus
Gene Knockout Techniques
Aptitude
Telomerase
Dentate Gyrus
Reverse Transcription
X-Rays
Transcription
Viruses
Spatial Memory
Genes
Irradiation
X rays
Networks (circuits)

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

Cite this

Zhou, Qi Gang ; Liu, Meng Ying ; Lee, Han Woong ; Ishikawa, Fuyuki ; Devkota, Sushil ; Shen, Xin Ru ; Jin, Xin ; Wu, Hai Yin ; Liu, Zhigang ; Liu, Xiao ; Jin, Xun ; Zhou, Hai Hui ; Ro, Eun Jeoung ; Zhang, Jing ; Zhang, Yu ; Lin, Yu Hui ; Suh, Hoonkyo ; Zhu, Dong Ya. / Hippocampal TERT Regulates Spatial Memory Formation through Modulation of Neural Development. In: Stem Cell Reports. 2017 ; Vol. 9, No. 2. pp. 543-556.
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Zhou, QG, Liu, MY, Lee, HW, Ishikawa, F, Devkota, S, Shen, XR, Jin, X, Wu, HY, Liu, Z, Liu, X, Jin, X, Zhou, HH, Ro, EJ, Zhang, J, Zhang, Y, Lin, YH, Suh, H & Zhu, DY 2017, 'Hippocampal TERT Regulates Spatial Memory Formation through Modulation of Neural Development', Stem Cell Reports, vol. 9, no. 2, pp. 543-556. https://doi.org/10.1016/j.stemcr.2017.06.014

Hippocampal TERT Regulates Spatial Memory Formation through Modulation of Neural Development. / Zhou, Qi Gang; Liu, Meng Ying; Lee, Han Woong; Ishikawa, Fuyuki; Devkota, Sushil; Shen, Xin Ru; Jin, Xin; Wu, Hai Yin; Liu, Zhigang; Liu, Xiao; Jin, Xun; Zhou, Hai Hui; Ro, Eun Jeoung; Zhang, Jing; Zhang, Yu; Lin, Yu Hui; Suh, Hoonkyo; Zhu, Dong Ya.

In: Stem Cell Reports, Vol. 9, No. 2, 08.08.2017, p. 543-556.

Research output: Contribution to journalArticle

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AU - Zhou, Qi Gang

AU - Liu, Meng Ying

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AU - Ishikawa, Fuyuki

AU - Devkota, Sushil

AU - Shen, Xin Ru

AU - Jin, Xin

AU - Wu, Hai Yin

AU - Liu, Zhigang

AU - Liu, Xiao

AU - Jin, Xun

AU - Zhou, Hai Hui

AU - Ro, Eun Jeoung

AU - Zhang, Jing

AU - Zhang, Yu

AU - Lin, Yu Hui

AU - Suh, Hoonkyo

AU - Zhu, Dong Ya

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