HIV Antiretroviral Resistance Mutations among Antiretroviral Treatment-Naive and-Experienced Patients in South Korea

Min Hyung Kim, Je Eun Song, Jin Young Ahn, Yong Chan Kim, Dong Hyun Oh, Heun Choi, Hea Won Ann, Jae Kyoung Kim, Sun Bean Kim, Su Jin Jeong, Nam Su Ku, Sang Hoon Han, Young Goo Song, June Myung Kim, JunYong Choi

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Abstract

The purpose of this study was to assess the prevalence and characteristics of HIV drug resistance mutations among antiretroviral therapy (ART)-naive and ART-experienced patients in South Korea. A total of 50 ART-naive and 34 ART-experienced Korean HIV-1-infected patients who visited an urban hospital from February 2007 to March 2011 were included. Most patients (86.9%) were infected with clade B HIV-1. Six (12%) ART-naive and 22 (64.7%) ART-experienced patients had HIV strains with resistance mutations. Among ART-naive patients, V179D was the most common mutation, being found in five ART-naive patients. Among ART-experienced patients, M184V was the most common mutation. Eight of 34 ART-experienced patients had thymidine analogue mutations (TAMs). The prevalence of drug-resistant HIV-1 in ART-naive patients was higher than in previous reports, and 50% of patients with virologic failure harbored strains with multiple resistance mutations. HIV drug resistance testing should be recommended to guide therapy of ART-naive patients in South Korea.

Original languageEnglish
Pages (from-to)1617-1620
Number of pages4
JournalAIDS Research and Human Retroviruses
Volume29
Issue number12
DOIs
Publication statusPublished - 2013 Dec 1

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All Science Journal Classification (ASJC) codes

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Kim, M. H., Song, J. E., Ahn, J. Y., Kim, Y. C., Oh, D. H., Choi, H., Ann, H. W., Kim, J. K., Kim, S. B., Jeong, S. J., Ku, N. S., Han, S. H., Song, Y. G., Kim, J. M., & Choi, J. (2013). HIV Antiretroviral Resistance Mutations among Antiretroviral Treatment-Naive and-Experienced Patients in South Korea. AIDS Research and Human Retroviruses, 29(12), 1617-1620. https://doi.org/10.1089/aid.2013.0184