HIV Antiretroviral Resistance Mutations among Antiretroviral Treatment-Naive and-Experienced Patients in South Korea

Min Hyung Kim, Je Eun Song, Jin Young Ahn, Yong Chan Kim, Dong Hyun Oh, Heun Choi, Hea Won Ann, Jae Kyoung Kim, Sun Bean Kim, Su Jin Jeong, Nam Su Ku, Sang Hoon Han, Young Goo Song, June Myung Kim, JunYong Choi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The purpose of this study was to assess the prevalence and characteristics of HIV drug resistance mutations among antiretroviral therapy (ART)-naive and ART-experienced patients in South Korea. A total of 50 ART-naive and 34 ART-experienced Korean HIV-1-infected patients who visited an urban hospital from February 2007 to March 2011 were included. Most patients (86.9%) were infected with clade B HIV-1. Six (12%) ART-naive and 22 (64.7%) ART-experienced patients had HIV strains with resistance mutations. Among ART-naive patients, V179D was the most common mutation, being found in five ART-naive patients. Among ART-experienced patients, M184V was the most common mutation. Eight of 34 ART-experienced patients had thymidine analogue mutations (TAMs). The prevalence of drug-resistant HIV-1 in ART-naive patients was higher than in previous reports, and 50% of patients with virologic failure harbored strains with multiple resistance mutations. HIV drug resistance testing should be recommended to guide therapy of ART-naive patients in South Korea.

Original languageEnglish
Pages (from-to)1617-1620
Number of pages4
JournalAIDS Research and Human Retroviruses
Volume29
Issue number12
DOIs
Publication statusPublished - 2013 Dec 1

Fingerprint

Republic of Korea
HIV
Mutation
Therapeutics
HIV-1
Drug Resistance
Urban Hospitals
Thymidine

All Science Journal Classification (ASJC) codes

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Kim, Min Hyung ; Song, Je Eun ; Ahn, Jin Young ; Kim, Yong Chan ; Oh, Dong Hyun ; Choi, Heun ; Ann, Hea Won ; Kim, Jae Kyoung ; Kim, Sun Bean ; Jeong, Su Jin ; Ku, Nam Su ; Han, Sang Hoon ; Song, Young Goo ; Kim, June Myung ; Choi, JunYong. / HIV Antiretroviral Resistance Mutations among Antiretroviral Treatment-Naive and-Experienced Patients in South Korea. In: AIDS Research and Human Retroviruses. 2013 ; Vol. 29, No. 12. pp. 1617-1620.
@article{e17e22aed175455b8ecf4075bbf15a59,
title = "HIV Antiretroviral Resistance Mutations among Antiretroviral Treatment-Naive and-Experienced Patients in South Korea",
abstract = "The purpose of this study was to assess the prevalence and characteristics of HIV drug resistance mutations among antiretroviral therapy (ART)-naive and ART-experienced patients in South Korea. A total of 50 ART-naive and 34 ART-experienced Korean HIV-1-infected patients who visited an urban hospital from February 2007 to March 2011 were included. Most patients (86.9{\%}) were infected with clade B HIV-1. Six (12{\%}) ART-naive and 22 (64.7{\%}) ART-experienced patients had HIV strains with resistance mutations. Among ART-naive patients, V179D was the most common mutation, being found in five ART-naive patients. Among ART-experienced patients, M184V was the most common mutation. Eight of 34 ART-experienced patients had thymidine analogue mutations (TAMs). The prevalence of drug-resistant HIV-1 in ART-naive patients was higher than in previous reports, and 50{\%} of patients with virologic failure harbored strains with multiple resistance mutations. HIV drug resistance testing should be recommended to guide therapy of ART-naive patients in South Korea.",
author = "Kim, {Min Hyung} and Song, {Je Eun} and Ahn, {Jin Young} and Kim, {Yong Chan} and Oh, {Dong Hyun} and Heun Choi and Ann, {Hea Won} and Kim, {Jae Kyoung} and Kim, {Sun Bean} and Jeong, {Su Jin} and Ku, {Nam Su} and Han, {Sang Hoon} and Song, {Young Goo} and Kim, {June Myung} and JunYong Choi",
year = "2013",
month = "12",
day = "1",
doi = "10.1089/aid.2013.0184",
language = "English",
volume = "29",
pages = "1617--1620",
journal = "AIDS Research and Human Retroviruses",
issn = "0889-2229",
publisher = "Mary Ann Liebert Inc.",
number = "12",

}

Kim, MH, Song, JE, Ahn, JY, Kim, YC, Oh, DH, Choi, H, Ann, HW, Kim, JK, Kim, SB, Jeong, SJ, Ku, NS, Han, SH, Song, YG, Kim, JM & Choi, J 2013, 'HIV Antiretroviral Resistance Mutations among Antiretroviral Treatment-Naive and-Experienced Patients in South Korea', AIDS Research and Human Retroviruses, vol. 29, no. 12, pp. 1617-1620. https://doi.org/10.1089/aid.2013.0184

HIV Antiretroviral Resistance Mutations among Antiretroviral Treatment-Naive and-Experienced Patients in South Korea. / Kim, Min Hyung; Song, Je Eun; Ahn, Jin Young; Kim, Yong Chan; Oh, Dong Hyun; Choi, Heun; Ann, Hea Won; Kim, Jae Kyoung; Kim, Sun Bean; Jeong, Su Jin; Ku, Nam Su; Han, Sang Hoon; Song, Young Goo; Kim, June Myung; Choi, JunYong.

In: AIDS Research and Human Retroviruses, Vol. 29, No. 12, 01.12.2013, p. 1617-1620.

Research output: Contribution to journalArticle

TY - JOUR

T1 - HIV Antiretroviral Resistance Mutations among Antiretroviral Treatment-Naive and-Experienced Patients in South Korea

AU - Kim, Min Hyung

AU - Song, Je Eun

AU - Ahn, Jin Young

AU - Kim, Yong Chan

AU - Oh, Dong Hyun

AU - Choi, Heun

AU - Ann, Hea Won

AU - Kim, Jae Kyoung

AU - Kim, Sun Bean

AU - Jeong, Su Jin

AU - Ku, Nam Su

AU - Han, Sang Hoon

AU - Song, Young Goo

AU - Kim, June Myung

AU - Choi, JunYong

PY - 2013/12/1

Y1 - 2013/12/1

N2 - The purpose of this study was to assess the prevalence and characteristics of HIV drug resistance mutations among antiretroviral therapy (ART)-naive and ART-experienced patients in South Korea. A total of 50 ART-naive and 34 ART-experienced Korean HIV-1-infected patients who visited an urban hospital from February 2007 to March 2011 were included. Most patients (86.9%) were infected with clade B HIV-1. Six (12%) ART-naive and 22 (64.7%) ART-experienced patients had HIV strains with resistance mutations. Among ART-naive patients, V179D was the most common mutation, being found in five ART-naive patients. Among ART-experienced patients, M184V was the most common mutation. Eight of 34 ART-experienced patients had thymidine analogue mutations (TAMs). The prevalence of drug-resistant HIV-1 in ART-naive patients was higher than in previous reports, and 50% of patients with virologic failure harbored strains with multiple resistance mutations. HIV drug resistance testing should be recommended to guide therapy of ART-naive patients in South Korea.

AB - The purpose of this study was to assess the prevalence and characteristics of HIV drug resistance mutations among antiretroviral therapy (ART)-naive and ART-experienced patients in South Korea. A total of 50 ART-naive and 34 ART-experienced Korean HIV-1-infected patients who visited an urban hospital from February 2007 to March 2011 were included. Most patients (86.9%) were infected with clade B HIV-1. Six (12%) ART-naive and 22 (64.7%) ART-experienced patients had HIV strains with resistance mutations. Among ART-naive patients, V179D was the most common mutation, being found in five ART-naive patients. Among ART-experienced patients, M184V was the most common mutation. Eight of 34 ART-experienced patients had thymidine analogue mutations (TAMs). The prevalence of drug-resistant HIV-1 in ART-naive patients was higher than in previous reports, and 50% of patients with virologic failure harbored strains with multiple resistance mutations. HIV drug resistance testing should be recommended to guide therapy of ART-naive patients in South Korea.

UR - http://www.scopus.com/inward/record.url?scp=84888324337&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888324337&partnerID=8YFLogxK

U2 - 10.1089/aid.2013.0184

DO - 10.1089/aid.2013.0184

M3 - Article

VL - 29

SP - 1617

EP - 1620

JO - AIDS Research and Human Retroviruses

JF - AIDS Research and Human Retroviruses

SN - 0889-2229

IS - 12

ER -