HLA alleles in Korean patients with Takayasu arteritis

Sang Won Lee, Oh Joong Kwon, Min Chan Park, Heung Bum Oh, YongBeom Park, Soo Kon Lee

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In this study, we investigated the HLA allele and haplotype frequencies, and the association of HLA alleles with serious complications and angiographic findings in Korean patients with Takayasu arteritis (TA) compared with healthy controls. Sixty-one patients (56 women, 5 men), diagnosed with TA between January 1995 and December 2005, were studied. Ninety-five healthy men and women were selected as controls. Clinical manifestations were assessed and angiographies were performed at the time of diagnosis in all TA patients. Genotypes of the HLA-A, -B and -DRB1 loci were determined using the polymerase chain reaction-sequencing-based typing (PCR-SBT) method. The mean age at the time of diagnosis of TA was 37.0 ± 12.1 years. Compared with controls, the frequencies of A*3001 (p = 0.048), B*5201 (p = 0.025), and DRB1*1502 (p = 0.046) alleles were significantly higher in TA patients, and the frequency of A*2602 was significantly lower in TA patients when compared with controls (p = 0.047). The haplotype containing A*2402-B*5201-DRB1*1502 was significantly increased in TA patients (χ2 = 5.45, p = 0.01). Further, among the serious complication of TA, congestive heart failure (CHF) was found to be associated with B*5201 (OR = 5.94, p < 0.05, 95% CI = 1.04∼33.85). These data suggest that A*3001, B*5201, and DRB1*1502 alleles might increase the susceptibility to TA, while A*2602 might protect against TA. Further, our results reveal that the haplotype A*2402-B*5201-DRB1502 could be a risk factor for TA, and the allele B*5201 is significantly associated with CHF.

Original languageEnglish
JournalClinical and experimental rheumatology
Volume25
Issue number1 SUPPL. 44
Publication statusPublished - 2007 Jan 1

Fingerprint

Takayasu Arteritis
Alleles
Haplotypes
Heart Failure
HLA-A Antigens
HLA-B Antigens
Gene Frequency
Angiography
Genotype

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Lee, S. W., Kwon, O. J., Park, M. C., Oh, H. B., Park, Y., & Lee, S. K. (2007). HLA alleles in Korean patients with Takayasu arteritis. Clinical and experimental rheumatology, 25(1 SUPPL. 44).
Lee, Sang Won ; Kwon, Oh Joong ; Park, Min Chan ; Oh, Heung Bum ; Park, YongBeom ; Lee, Soo Kon. / HLA alleles in Korean patients with Takayasu arteritis. In: Clinical and experimental rheumatology. 2007 ; Vol. 25, No. 1 SUPPL. 44.
@article{bd690041e6834cb2b9a8870bb9f2875a,
title = "HLA alleles in Korean patients with Takayasu arteritis",
abstract = "In this study, we investigated the HLA allele and haplotype frequencies, and the association of HLA alleles with serious complications and angiographic findings in Korean patients with Takayasu arteritis (TA) compared with healthy controls. Sixty-one patients (56 women, 5 men), diagnosed with TA between January 1995 and December 2005, were studied. Ninety-five healthy men and women were selected as controls. Clinical manifestations were assessed and angiographies were performed at the time of diagnosis in all TA patients. Genotypes of the HLA-A, -B and -DRB1 loci were determined using the polymerase chain reaction-sequencing-based typing (PCR-SBT) method. The mean age at the time of diagnosis of TA was 37.0 ± 12.1 years. Compared with controls, the frequencies of A*3001 (p = 0.048), B*5201 (p = 0.025), and DRB1*1502 (p = 0.046) alleles were significantly higher in TA patients, and the frequency of A*2602 was significantly lower in TA patients when compared with controls (p = 0.047). The haplotype containing A*2402-B*5201-DRB1*1502 was significantly increased in TA patients (χ2 = 5.45, p = 0.01). Further, among the serious complication of TA, congestive heart failure (CHF) was found to be associated with B*5201 (OR = 5.94, p < 0.05, 95{\%} CI = 1.04∼33.85). These data suggest that A*3001, B*5201, and DRB1*1502 alleles might increase the susceptibility to TA, while A*2602 might protect against TA. Further, our results reveal that the haplotype A*2402-B*5201-DRB1502 could be a risk factor for TA, and the allele B*5201 is significantly associated with CHF.",
author = "Lee, {Sang Won} and Kwon, {Oh Joong} and Park, {Min Chan} and Oh, {Heung Bum} and YongBeom Park and Lee, {Soo Kon}",
year = "2007",
month = "1",
day = "1",
language = "English",
volume = "25",
journal = "Clinical and Experimental Rheumatology",
issn = "0392-856X",
publisher = "Clinical and Experimental Rheumatology S.A.S.",
number = "1 SUPPL. 44",

}

Lee, SW, Kwon, OJ, Park, MC, Oh, HB, Park, Y & Lee, SK 2007, 'HLA alleles in Korean patients with Takayasu arteritis', Clinical and experimental rheumatology, vol. 25, no. 1 SUPPL. 44.

HLA alleles in Korean patients with Takayasu arteritis. / Lee, Sang Won; Kwon, Oh Joong; Park, Min Chan; Oh, Heung Bum; Park, YongBeom; Lee, Soo Kon.

In: Clinical and experimental rheumatology, Vol. 25, No. 1 SUPPL. 44, 01.01.2007.

Research output: Contribution to journalArticle

TY - JOUR

T1 - HLA alleles in Korean patients with Takayasu arteritis

AU - Lee, Sang Won

AU - Kwon, Oh Joong

AU - Park, Min Chan

AU - Oh, Heung Bum

AU - Park, YongBeom

AU - Lee, Soo Kon

PY - 2007/1/1

Y1 - 2007/1/1

N2 - In this study, we investigated the HLA allele and haplotype frequencies, and the association of HLA alleles with serious complications and angiographic findings in Korean patients with Takayasu arteritis (TA) compared with healthy controls. Sixty-one patients (56 women, 5 men), diagnosed with TA between January 1995 and December 2005, were studied. Ninety-five healthy men and women were selected as controls. Clinical manifestations were assessed and angiographies were performed at the time of diagnosis in all TA patients. Genotypes of the HLA-A, -B and -DRB1 loci were determined using the polymerase chain reaction-sequencing-based typing (PCR-SBT) method. The mean age at the time of diagnosis of TA was 37.0 ± 12.1 years. Compared with controls, the frequencies of A*3001 (p = 0.048), B*5201 (p = 0.025), and DRB1*1502 (p = 0.046) alleles were significantly higher in TA patients, and the frequency of A*2602 was significantly lower in TA patients when compared with controls (p = 0.047). The haplotype containing A*2402-B*5201-DRB1*1502 was significantly increased in TA patients (χ2 = 5.45, p = 0.01). Further, among the serious complication of TA, congestive heart failure (CHF) was found to be associated with B*5201 (OR = 5.94, p < 0.05, 95% CI = 1.04∼33.85). These data suggest that A*3001, B*5201, and DRB1*1502 alleles might increase the susceptibility to TA, while A*2602 might protect against TA. Further, our results reveal that the haplotype A*2402-B*5201-DRB1502 could be a risk factor for TA, and the allele B*5201 is significantly associated with CHF.

AB - In this study, we investigated the HLA allele and haplotype frequencies, and the association of HLA alleles with serious complications and angiographic findings in Korean patients with Takayasu arteritis (TA) compared with healthy controls. Sixty-one patients (56 women, 5 men), diagnosed with TA between January 1995 and December 2005, were studied. Ninety-five healthy men and women were selected as controls. Clinical manifestations were assessed and angiographies were performed at the time of diagnosis in all TA patients. Genotypes of the HLA-A, -B and -DRB1 loci were determined using the polymerase chain reaction-sequencing-based typing (PCR-SBT) method. The mean age at the time of diagnosis of TA was 37.0 ± 12.1 years. Compared with controls, the frequencies of A*3001 (p = 0.048), B*5201 (p = 0.025), and DRB1*1502 (p = 0.046) alleles were significantly higher in TA patients, and the frequency of A*2602 was significantly lower in TA patients when compared with controls (p = 0.047). The haplotype containing A*2402-B*5201-DRB1*1502 was significantly increased in TA patients (χ2 = 5.45, p = 0.01). Further, among the serious complication of TA, congestive heart failure (CHF) was found to be associated with B*5201 (OR = 5.94, p < 0.05, 95% CI = 1.04∼33.85). These data suggest that A*3001, B*5201, and DRB1*1502 alleles might increase the susceptibility to TA, while A*2602 might protect against TA. Further, our results reveal that the haplotype A*2402-B*5201-DRB1502 could be a risk factor for TA, and the allele B*5201 is significantly associated with CHF.

UR - http://www.scopus.com/inward/record.url?scp=34247469799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247469799&partnerID=8YFLogxK

M3 - Article

VL - 25

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

SN - 0392-856X

IS - 1 SUPPL. 44

ER -

Lee SW, Kwon OJ, Park MC, Oh HB, Park Y, Lee SK. HLA alleles in Korean patients with Takayasu arteritis. Clinical and experimental rheumatology. 2007 Jan 1;25(1 SUPPL. 44).