HLA class II allele associations in Korean patients with pemphigus

C. W. Lee, H. Y. Yang, S. C. Kim, J. H. Jung, J. J. Hwang

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14 Citations (Scopus)

Abstract

Background: Studies at the population level have demonstrated associations between pemphigus (pemphigus vulgaris, PV, and pemphigus foliaceus, PF) and particular HLA haplotypes, which suggests that there may be a genetic predisposition for the disease. Objective/Methods: The aim of the present study was to examine the distribution/frequency pattern of HLA class II alleles (DRB1, DQA1 and DQB1) from a group of 30 Korean patients with pemphigus (15 PV and 15 PF) by PCR amplification with sequence-specific primers. Results: In PV, the frequency of DRB1*01 allele was found to be significantly high (p(c) = 0.0014); in PF, DRB1*01, DQA1*0302 and DQB1*0603 alleles showed positive associations with statistical significances (p(c) = 0.0002, 0.0007 and 0.0067, respectively), when compared with those found in Korean controls. Conclusions: In this small-sample study, findings of allelic frequencies among Korean patients with pemphigus are somewhat different from those found in other populations.

Original languageEnglish
Pages (from-to)349-352
Number of pages4
JournalDermatology
Volume197
Issue number4
DOIs
Publication statusPublished - 1998

All Science Journal Classification (ASJC) codes

  • Dermatology

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    Lee, C. W., Yang, H. Y., Kim, S. C., Jung, J. H., & Hwang, J. J. (1998). HLA class II allele associations in Korean patients with pemphigus. Dermatology, 197(4), 349-352. https://doi.org/10.1159/000018030