Hollow silica nanocontainers as drug delivery vehicles

Jaemoon Yang; Jaewon Lee; Jinyoung Kang; Kwangyeol Lee; Jin Suck Suh; Ho Geun Yoon; Yong Mip Huh; Seungjoo Haam

doi:10.1021/la701688t

Hollow silica nanocontainers as drug delivery vehicles

Jaemoon Yang, Jaewon Lee, Jinyoung Kang, Kwangyeol Lee, Jin Suck Suh, Ho Geun Yoon, Yong Mip Huh, Seungjoo Haam

Research output: Contribution to journal › Article › peer-review

240 Citations (Scopus)

Abstract

Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe₃O₄ nanocrystals, as templates. The core cavity was obtained by removal of Fe₃O₄ phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.

Original language	English
Pages (from-to)	3417-3421
Number of pages	5
Journal	Langmuir
Volume	24
Issue number	7
DOIs	https://doi.org/10.1021/la701688t
Publication status	Published - 2008 Apr 1

All Science Journal Classification (ASJC) codes

Materials Science(all)
Condensed Matter Physics
Surfaces and Interfaces
Spectroscopy
Electrochemistry

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10.1021/la701688t

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AU - Yang, Jaemoon

AU - Lee, Jaewon

AU - Kang, Jinyoung

AU - Lee, Kwangyeol

AU - Suh, Jin Suck

AU - Yoon, Ho Geun

AU - Huh, Yong Mip

AU - Haam, Seungjoo

PY - 2008/4/1

Y1 - 2008/4/1

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AB - Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe3O4 nanocrystals, as templates. The core cavity was obtained by removal of Fe3O4 phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.

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JO - Langmuir

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Hollow silica nanocontainers as drug delivery vehicles

Abstract

All Science Journal Classification (ASJC) codes

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