Abstract
OBJECTIVE: This study evaluated the effect of home oxygen therapy (HOT) on hospital admissions in chronic obstructive pulmonary disease (COPD) patients.
DESIGN AND SETTING: Using nationwide health insurance claims from 2002-2012, we conducted a longitudinal population-based retrospective cohort study.
PARTICIPANTS: Individuals who were aged 40 years or above and newly diagnosed with COPD in 2005.
OUTCOME MEASURES: The primary outcome was total number of hospitalisations during the study period. Participants were matched using HOT propensity scores and were stratified by respiratory impairment (grade 1: FEV1 ≤25% or PaO2 ≤55 mm Hg; grade 2: FEV1 ≤30% or PaO2 56-60 mm Hg; grade 3: FEV1 ≤40% or PaO2 61-65 mm Hg; 'no grade': FEV1 or PaO2 unknown), then a negative binomial regression analysis was performed for each group.
RESULTS: Of the 36,761 COPD patients included in our study, 1330 (3.6%) received HOT. In a multivariate analysis of grade 1 patients performed before propensity score matching, the adjusted relative risk of hospitalisation for patients who did not receive HOT was 1.27 (95% CI 1.01 to 1.60). In a multivariate analysis of grade 1 patients performed after matching, the adjusted relative risk for patients who did not receive HOT was 1.65 (95% CI 1.25 to 2.18). In grade 2 or grade 3 patients, no statistical difference in hospital admission risk was detected. In the 'no grade' group of patients, HOT was associated with an increased risk of hospitalisation.
CONCLUSIONS: HOT reduces the risk of hospital admission in COPD patients with severe hypoxaemia. However, apart from these patients, HOT use is not associated with hospital admissions.
Original language | English |
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Pages (from-to) | e009065 |
Journal | BMJ open |
Volume | 5 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2015 Nov 30 |
Bibliographical note
Publisher Copyright:Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
All Science Journal Classification (ASJC) codes
- Medicine(all)