Homoisoflavanone inhibits retinal neovascularization through cell cycle arrest with decrease of cdc2 expression

Jeong Hun Kim, Ki Hyun Kim, Jin Hyoung Kim, Young Suk Yu, Young Myeong Kim, Kyu Won Kim, Ho Jeong Kwon

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Neovascularization in the eye is the most common cause of blindness in all age groups; retinopathy of prematurity (ROP), diabetic retinopathy, and age-related macular degeneration. Despite current advances in surgical treatments, ROP remains as the most serious problem of vision loss in children. Here, we report that homoisoflavanone, a natural product from Cremastra appendiculata, significantly reduces retinal neovascularization in a mouse model of ROP. Homoisoflavanone inhibited the cell growth of HUVECs, but its cytotoxic effect was not observed in a concentration range of 1-20 μM. HUVECs population gradually increased in G2/M phase and reduced in G0/G1 and S phases after exposure to the compound. Homoisoflavanone decreased the level of cdc2 expression whereas the level of p21WAF1 expression was increased in a dose-dependent manner. These data demonstrate that homoisoflavanone could inhibit retinal neovascularization and be applied in the treatment of other vasoproliferative retinopathies.

Original languageEnglish
Pages (from-to)848-852
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume362
Issue number4
DOIs
Publication statusPublished - 2007 Nov 3

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Retinal Neovascularization
Retinopathy of Prematurity
Cell growth
Cell Cycle Checkpoints
Biological Products
Cells
Cell Cycle Resting Phase
G2 Phase
Human Umbilical Vein Endothelial Cells
Macular Degeneration
G1 Phase
Diabetic Retinopathy
Blindness
S Phase
Cell Division
Age Groups
Therapeutics
Growth
Population

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Kim, Jeong Hun ; Kim, Ki Hyun ; Kim, Jin Hyoung ; Yu, Young Suk ; Kim, Young Myeong ; Kim, Kyu Won ; Kwon, Ho Jeong. / Homoisoflavanone inhibits retinal neovascularization through cell cycle arrest with decrease of cdc2 expression. In: Biochemical and Biophysical Research Communications. 2007 ; Vol. 362, No. 4. pp. 848-852.
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Homoisoflavanone inhibits retinal neovascularization through cell cycle arrest with decrease of cdc2 expression. / Kim, Jeong Hun; Kim, Ki Hyun; Kim, Jin Hyoung; Yu, Young Suk; Kim, Young Myeong; Kim, Kyu Won; Kwon, Ho Jeong.

In: Biochemical and Biophysical Research Communications, Vol. 362, No. 4, 03.11.2007, p. 848-852.

Research output: Contribution to journalArticle

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