How can we enhance the performance of liver stiffness measurement using fibroscan in diagnosing liver cirrhosis in patients with chronic hepatitis B?

Seungup Kim, doyoung kim, Junyong Park, Jin Ha Lee, SangHoon Ahn, Ja Kyung Kim, Yong Han Paik, Kwan Sik Lee, Chae Yoon Chon, Eun Hee Choi, Ki Jun Song, Young Nyun Park, KwangHyub Han

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Goal: This study aimed to enhance the diagnostic accuracy by defining different cutoff liver stiffness measurement (LSM) values according to alanine aminotransferase (ALT) level and combining LSM with noninvasive models in patients with chronic hepatitis B (CHB). Background: Several studies have indicated that ALT influences LSM using FibroScan. Study: The study prospectively enrolled 200 patients (143 men, mean age 45.4y) between June 2007 and November 2008 who had been diagnosed with CHB and underwent both liver biopsy and LSM on the same day. Results: The area under the receiver operating characteristic curves (AUROC) of LSM for predicting cirrhosis in patients with ALT ≤upper limit of normal (ULN) was higher than that of all patients or those with ALT >ULN and ≤2× ULN (AUROC=0.884 vs. 0.849 and 0.867). The cutoff LSM values for ≥F2, ≥F3, and F4 were 6.0, 7.5, and 10.1kPa, respectively, in patients with ALT ≤ULN, whereas they were 8.9, 11.0, and 15.5kPa, respectively, in those with ALT >ULN and ≤2× ULN. The combination of LSM and the age-spleen-platelet ratio index performed the best at predicting cirrhosis, regardless of ALT level (AUROC=0.917 in patients with ALT ≤ULN, 0.909 in those with ALT ≤2× ULN, and 0.894 in all patients). Conclusions: Different cutoff LSM values according to ALT level and combination with age-spleen-platelet ratio index can enhance the performance of LSM in CHB, regardless of ALT level.

Original languageEnglish
Pages (from-to)66-71
Number of pages6
JournalJournal of Clinical Gastroenterology
Volume44
Issue number1
DOIs
Publication statusPublished - 2010 Jan 1

Fingerprint

Chronic Hepatitis B
Alanine Transaminase
Liver Cirrhosis
Liver
ROC Curve
Fibrosis
Blood Platelets
Spleen
Biopsy

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Kim, Seungup ; kim, doyoung ; Park, Junyong ; Lee, Jin Ha ; Ahn, SangHoon ; Kim, Ja Kyung ; Paik, Yong Han ; Lee, Kwan Sik ; Chon, Chae Yoon ; Choi, Eun Hee ; Song, Ki Jun ; Park, Young Nyun ; Han, KwangHyub. / How can we enhance the performance of liver stiffness measurement using fibroscan in diagnosing liver cirrhosis in patients with chronic hepatitis B?. In: Journal of Clinical Gastroenterology. 2010 ; Vol. 44, No. 1. pp. 66-71.
@article{8be9203504dc4722879cc8369c155d67,
title = "How can we enhance the performance of liver stiffness measurement using fibroscan in diagnosing liver cirrhosis in patients with chronic hepatitis B?",
abstract = "Goal: This study aimed to enhance the diagnostic accuracy by defining different cutoff liver stiffness measurement (LSM) values according to alanine aminotransferase (ALT) level and combining LSM with noninvasive models in patients with chronic hepatitis B (CHB). Background: Several studies have indicated that ALT influences LSM using FibroScan. Study: The study prospectively enrolled 200 patients (143 men, mean age 45.4y) between June 2007 and November 2008 who had been diagnosed with CHB and underwent both liver biopsy and LSM on the same day. Results: The area under the receiver operating characteristic curves (AUROC) of LSM for predicting cirrhosis in patients with ALT ≤upper limit of normal (ULN) was higher than that of all patients or those with ALT >ULN and ≤2× ULN (AUROC=0.884 vs. 0.849 and 0.867). The cutoff LSM values for ≥F2, ≥F3, and F4 were 6.0, 7.5, and 10.1kPa, respectively, in patients with ALT ≤ULN, whereas they were 8.9, 11.0, and 15.5kPa, respectively, in those with ALT >ULN and ≤2× ULN. The combination of LSM and the age-spleen-platelet ratio index performed the best at predicting cirrhosis, regardless of ALT level (AUROC=0.917 in patients with ALT ≤ULN, 0.909 in those with ALT ≤2× ULN, and 0.894 in all patients). Conclusions: Different cutoff LSM values according to ALT level and combination with age-spleen-platelet ratio index can enhance the performance of LSM in CHB, regardless of ALT level.",
author = "Seungup Kim and doyoung kim and Junyong Park and Lee, {Jin Ha} and SangHoon Ahn and Kim, {Ja Kyung} and Paik, {Yong Han} and Lee, {Kwan Sik} and Chon, {Chae Yoon} and Choi, {Eun Hee} and Song, {Ki Jun} and Park, {Young Nyun} and KwangHyub Han",
year = "2010",
month = "1",
day = "1",
doi = "10.1097/MCG.0b013e3181a95c7f",
language = "English",
volume = "44",
pages = "66--71",
journal = "Journal of Clinical Gastroenterology",
issn = "0192-0790",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

How can we enhance the performance of liver stiffness measurement using fibroscan in diagnosing liver cirrhosis in patients with chronic hepatitis B? / Kim, Seungup; kim, doyoung; Park, Junyong; Lee, Jin Ha; Ahn, SangHoon; Kim, Ja Kyung; Paik, Yong Han; Lee, Kwan Sik; Chon, Chae Yoon; Choi, Eun Hee; Song, Ki Jun; Park, Young Nyun; Han, KwangHyub.

In: Journal of Clinical Gastroenterology, Vol. 44, No. 1, 01.01.2010, p. 66-71.

Research output: Contribution to journalArticle

TY - JOUR

T1 - How can we enhance the performance of liver stiffness measurement using fibroscan in diagnosing liver cirrhosis in patients with chronic hepatitis B?

AU - Kim, Seungup

AU - kim, doyoung

AU - Park, Junyong

AU - Lee, Jin Ha

AU - Ahn, SangHoon

AU - Kim, Ja Kyung

AU - Paik, Yong Han

AU - Lee, Kwan Sik

AU - Chon, Chae Yoon

AU - Choi, Eun Hee

AU - Song, Ki Jun

AU - Park, Young Nyun

AU - Han, KwangHyub

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Goal: This study aimed to enhance the diagnostic accuracy by defining different cutoff liver stiffness measurement (LSM) values according to alanine aminotransferase (ALT) level and combining LSM with noninvasive models in patients with chronic hepatitis B (CHB). Background: Several studies have indicated that ALT influences LSM using FibroScan. Study: The study prospectively enrolled 200 patients (143 men, mean age 45.4y) between June 2007 and November 2008 who had been diagnosed with CHB and underwent both liver biopsy and LSM on the same day. Results: The area under the receiver operating characteristic curves (AUROC) of LSM for predicting cirrhosis in patients with ALT ≤upper limit of normal (ULN) was higher than that of all patients or those with ALT >ULN and ≤2× ULN (AUROC=0.884 vs. 0.849 and 0.867). The cutoff LSM values for ≥F2, ≥F3, and F4 were 6.0, 7.5, and 10.1kPa, respectively, in patients with ALT ≤ULN, whereas they were 8.9, 11.0, and 15.5kPa, respectively, in those with ALT >ULN and ≤2× ULN. The combination of LSM and the age-spleen-platelet ratio index performed the best at predicting cirrhosis, regardless of ALT level (AUROC=0.917 in patients with ALT ≤ULN, 0.909 in those with ALT ≤2× ULN, and 0.894 in all patients). Conclusions: Different cutoff LSM values according to ALT level and combination with age-spleen-platelet ratio index can enhance the performance of LSM in CHB, regardless of ALT level.

AB - Goal: This study aimed to enhance the diagnostic accuracy by defining different cutoff liver stiffness measurement (LSM) values according to alanine aminotransferase (ALT) level and combining LSM with noninvasive models in patients with chronic hepatitis B (CHB). Background: Several studies have indicated that ALT influences LSM using FibroScan. Study: The study prospectively enrolled 200 patients (143 men, mean age 45.4y) between June 2007 and November 2008 who had been diagnosed with CHB and underwent both liver biopsy and LSM on the same day. Results: The area under the receiver operating characteristic curves (AUROC) of LSM for predicting cirrhosis in patients with ALT ≤upper limit of normal (ULN) was higher than that of all patients or those with ALT >ULN and ≤2× ULN (AUROC=0.884 vs. 0.849 and 0.867). The cutoff LSM values for ≥F2, ≥F3, and F4 were 6.0, 7.5, and 10.1kPa, respectively, in patients with ALT ≤ULN, whereas they were 8.9, 11.0, and 15.5kPa, respectively, in those with ALT >ULN and ≤2× ULN. The combination of LSM and the age-spleen-platelet ratio index performed the best at predicting cirrhosis, regardless of ALT level (AUROC=0.917 in patients with ALT ≤ULN, 0.909 in those with ALT ≤2× ULN, and 0.894 in all patients). Conclusions: Different cutoff LSM values according to ALT level and combination with age-spleen-platelet ratio index can enhance the performance of LSM in CHB, regardless of ALT level.

UR - http://www.scopus.com/inward/record.url?scp=75149148751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75149148751&partnerID=8YFLogxK

U2 - 10.1097/MCG.0b013e3181a95c7f

DO - 10.1097/MCG.0b013e3181a95c7f

M3 - Article

C2 - 19609218

AN - SCOPUS:75149148751

VL - 44

SP - 66

EP - 71

JO - Journal of Clinical Gastroenterology

JF - Journal of Clinical Gastroenterology

SN - 0192-0790

IS - 1

ER -