Visualization algorithms have been widely used for intuitive interrogation of genomic data and popularly used tools include MDS, t-SNE, and UMAP. However, these algorithms are not tuned for the visualization of binary data and none of them consider the hubness of observations for the visualization. In order to address these limitations, here we propose hubViz, a novel tool for hub-centric visualization of binary data. We evaluated the performance of hubViz with its application to the gene expression data measured in multiple brain regions of rats exposed to cocaine, the single-cell RNA-seq data of peripheral blood mononuclear cells treated with interferon beta, and the literature mining data to investigate relationships among diseases. We further evaluated the performance of hubViz using simulation studies. We showed that hubViz provides effective visual inspection by locating the hub in the center and the contrasting elements in the opposite sides around the center. We believe that hubViz and its software can be powerful tools that can improve visualizations of various genomic data. The hubViz is implemented as an R package hubviz, which is publicly available at https://dongjunchung.github.io/hubviz/.
Bibliographical noteFunding Information:
This work was supported by the National Institutes of Health [grant numbers R01-GM122078 , R21-CA209848 , U01-DA045300 awarded to DC], Yonsei University Research Fund [grant number 2019-22-0210 awarded to IHJ] and the National Research Foundation of Korea [grant number NRF 2020R1A2C1A01009881 ; Basic Science Research Program awarded to IHJ]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
© 2020 Elsevier B.V.
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Process Chemistry and Technology
- Computer Science Applications