Human herpesvirus 8‑negative effusion‑based lymphoma with indolent clinical behavior in an elderly patient: A case report and literature review

Moonsik Kim, Jiyeon An, Sun Och Yoon, Seung Hyun Yong, Jin Seok Kim, Woo Ick Yang, Ah Young Leem

Research output: Contribution to journalReview articlepeer-review

Abstract

Primary effusion lymphoma (PEL) is a B‑cell non‑Hodgkin's lymphoma that is usually characterized by lymphomatous effusions in the body cavity without any detectable tumor masses. According to the World Health Organization (WHO) schema for tumor classification, PEL is defined by the presence of human herpesvirus 8 (HHV8) in malignant lymphoid cells. However, a subset of effusion‑based B‑cell lymphoma is not HHV8‑positive and exhibits different clinicopathological characteristics. The 2017 WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues does not list HHV8‑negative effu‑ sion‑based lymphoma, which remains an underappreciated B‑cell lymphoma, as an individual entity. The present study reports a case of this rare type of lymphoma with indolent clinical behavior in a 75‑year‑old male patient receiving only symptomatic treatment. Additionally, a review of similar cases reported in the English literature is presented.

Original languageEnglish
JournalOncology Letters
Volume20
Issue number6
DOIs
Publication statusPublished - 2020 Oct 8

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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