Human immunodeficiency virus (HIV) and hepatitis virus coinfection among HIV-infected Korean patients: The Korea HIV/AIDS cohort study

Yong Chan Kim, Jin Young Ahn, June Myung Kim, Youn Jeong Kim, Dae Won Park, Young Kyung Yoon, Joon Young Song, Shin Woo Kim, Jin Soo Lee, Bo Youl Choi, Yun Su Choi, Ju Yeon Choi, Myung Guk Han, Chun Kang, Jun Yong Choi

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Abstract

Background: Despite declines in mortality and morbidity rates of patients with human immunodeficiency virus (HIV) infection as the result of highly active antiretroviral therapy, liver diseases due to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are a leading cause of death among HIV-infected patients. However, HIV and HBV or HCV coinfection is still poorly documented, and more information is needed to better understand the characteristics of HIV-infected patients in Korea. Materials and Methods: A cross-sectional study was performed to investigate clinical characteristics and prevalence of HBV and HCV infection in HIV patients enrolled in the Korea HIV/acquired immune deficiency syndrome (AIDS) cohort study from 17 institutions between December 2006 and July 2013. Results: Among the 1,218 HIV-infected participants, 541 were included in this study. The prevalence of HBV-HIV and HCV-HIV coinfection was 5.0% (27/541) and 1.7% (9/541), respectively. There was no patient who was positive for both HBs antigen and HCV antibody. In multivariate logistic regression analysis, HBV unvaccinated status was a significant risk factor for HBV-HIV coinfection (odds ratio = 4.95, 95% confidence interval = 1.43-17.13). Conclusion: HBV and HCV infection was more common in HIV-infected persons enrolled in the Korean HIV/AIDS cohort, than in the general population in Korea.

Original languageEnglish
Pages (from-to)268-274
Number of pages7
JournalInfection and Chemotherapy
Volume49
Issue number4
DOIs
Publication statusPublished - 2017 Dec 1

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Pharmacology (medical)

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    Kim, Y. C., Ahn, J. Y., Kim, J. M., Kim, Y. J., Park, D. W., Yoon, Y. K., Song, J. Y., Kim, S. W., Lee, J. S., Choi, B. Y., Choi, Y. S., Choi, J. Y., Han, M. G., Kang, C., & Choi, J. Y. (2017). Human immunodeficiency virus (HIV) and hepatitis virus coinfection among HIV-infected Korean patients: The Korea HIV/AIDS cohort study. Infection and Chemotherapy, 49(4), 268-274. https://doi.org/10.3947/ic.2017.49.4.268