Human immunodeficiency virus (HIV) and hepatitis virus coinfection among HIV-infected Korean patients

The Korea HIV/AIDS cohort study

Yong Chan Kim, Jin Young Ahn, June Myung Kim, Youn Jeong Kim, Dae Won Park, Young Kyung Yoon, Joon Young Song, Shin Woo Kim, Jin Soo Lee, Bo Youl Choi, Yun Su Choi, Ju Yeon Choi, Myung Guk Han, Chun Kang, JunYong Choi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Despite declines in mortality and morbidity rates of patients with human immunodeficiency virus (HIV) infection as the result of highly active antiretroviral therapy, liver diseases due to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are a leading cause of death among HIV-infected patients. However, HIV and HBV or HCV coinfection is still poorly documented, and more information is needed to better understand the characteristics of HIV-infected patients in Korea. Materials and Methods: A cross-sectional study was performed to investigate clinical characteristics and prevalence of HBV and HCV infection in HIV patients enrolled in the Korea HIV/acquired immune deficiency syndrome (AIDS) cohort study from 17 institutions between December 2006 and July 2013. Results: Among the 1,218 HIV-infected participants, 541 were included in this study. The prevalence of HBV-HIV and HCV-HIV coinfection was 5.0% (27/541) and 1.7% (9/541), respectively. There was no patient who was positive for both HBs antigen and HCV antibody. In multivariate logistic regression analysis, HBV unvaccinated status was a significant risk factor for HBV-HIV coinfection (odds ratio = 4.95, 95% confidence interval = 1.43-17.13). Conclusion: HBV and HCV infection was more common in HIV-infected persons enrolled in the Korean HIV/AIDS cohort, than in the general population in Korea.

Original languageEnglish
Pages (from-to)268-274
Number of pages7
JournalInfection and Chemotherapy
Volume49
Issue number4
DOIs
Publication statusPublished - 2017 Dec 1

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Hepatitis Viruses
Korea
Coinfection
Acquired Immunodeficiency Syndrome
Cohort Studies
HIV
Hepatitis B virus
Hepacivirus
Virus Diseases
Hepatitis C Antibodies
Highly Active Antiretroviral Therapy
Chronic Hepatitis B
HIV-1
Liver Diseases
Cause of Death
Cross-Sectional Studies
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Kim, Yong Chan ; Ahn, Jin Young ; Kim, June Myung ; Kim, Youn Jeong ; Park, Dae Won ; Yoon, Young Kyung ; Song, Joon Young ; Kim, Shin Woo ; Lee, Jin Soo ; Choi, Bo Youl ; Choi, Yun Su ; Choi, Ju Yeon ; Han, Myung Guk ; Kang, Chun ; Choi, JunYong. / Human immunodeficiency virus (HIV) and hepatitis virus coinfection among HIV-infected Korean patients : The Korea HIV/AIDS cohort study. In: Infection and Chemotherapy. 2017 ; Vol. 49, No. 4. pp. 268-274.
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title = "Human immunodeficiency virus (HIV) and hepatitis virus coinfection among HIV-infected Korean patients: The Korea HIV/AIDS cohort study",
abstract = "Background: Despite declines in mortality and morbidity rates of patients with human immunodeficiency virus (HIV) infection as the result of highly active antiretroviral therapy, liver diseases due to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are a leading cause of death among HIV-infected patients. However, HIV and HBV or HCV coinfection is still poorly documented, and more information is needed to better understand the characteristics of HIV-infected patients in Korea. Materials and Methods: A cross-sectional study was performed to investigate clinical characteristics and prevalence of HBV and HCV infection in HIV patients enrolled in the Korea HIV/acquired immune deficiency syndrome (AIDS) cohort study from 17 institutions between December 2006 and July 2013. Results: Among the 1,218 HIV-infected participants, 541 were included in this study. The prevalence of HBV-HIV and HCV-HIV coinfection was 5.0{\%} (27/541) and 1.7{\%} (9/541), respectively. There was no patient who was positive for both HBs antigen and HCV antibody. In multivariate logistic regression analysis, HBV unvaccinated status was a significant risk factor for HBV-HIV coinfection (odds ratio = 4.95, 95{\%} confidence interval = 1.43-17.13). Conclusion: HBV and HCV infection was more common in HIV-infected persons enrolled in the Korean HIV/AIDS cohort, than in the general population in Korea.",
author = "Kim, {Yong Chan} and Ahn, {Jin Young} and Kim, {June Myung} and Kim, {Youn Jeong} and Park, {Dae Won} and Yoon, {Young Kyung} and Song, {Joon Young} and Kim, {Shin Woo} and Lee, {Jin Soo} and Choi, {Bo Youl} and Choi, {Yun Su} and Choi, {Ju Yeon} and Han, {Myung Guk} and Chun Kang and JunYong Choi",
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Kim, YC, Ahn, JY, Kim, JM, Kim, YJ, Park, DW, Yoon, YK, Song, JY, Kim, SW, Lee, JS, Choi, BY, Choi, YS, Choi, JY, Han, MG, Kang, C & Choi, J 2017, 'Human immunodeficiency virus (HIV) and hepatitis virus coinfection among HIV-infected Korean patients: The Korea HIV/AIDS cohort study', Infection and Chemotherapy, vol. 49, no. 4, pp. 268-274. https://doi.org/10.3947/ic.2017.49.4.268

Human immunodeficiency virus (HIV) and hepatitis virus coinfection among HIV-infected Korean patients : The Korea HIV/AIDS cohort study. / Kim, Yong Chan; Ahn, Jin Young; Kim, June Myung; Kim, Youn Jeong; Park, Dae Won; Yoon, Young Kyung; Song, Joon Young; Kim, Shin Woo; Lee, Jin Soo; Choi, Bo Youl; Choi, Yun Su; Choi, Ju Yeon; Han, Myung Guk; Kang, Chun; Choi, JunYong.

In: Infection and Chemotherapy, Vol. 49, No. 4, 01.12.2017, p. 268-274.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Human immunodeficiency virus (HIV) and hepatitis virus coinfection among HIV-infected Korean patients

T2 - The Korea HIV/AIDS cohort study

AU - Kim, Yong Chan

AU - Ahn, Jin Young

AU - Kim, June Myung

AU - Kim, Youn Jeong

AU - Park, Dae Won

AU - Yoon, Young Kyung

AU - Song, Joon Young

AU - Kim, Shin Woo

AU - Lee, Jin Soo

AU - Choi, Bo Youl

AU - Choi, Yun Su

AU - Choi, Ju Yeon

AU - Han, Myung Guk

AU - Kang, Chun

AU - Choi, JunYong

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Background: Despite declines in mortality and morbidity rates of patients with human immunodeficiency virus (HIV) infection as the result of highly active antiretroviral therapy, liver diseases due to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are a leading cause of death among HIV-infected patients. However, HIV and HBV or HCV coinfection is still poorly documented, and more information is needed to better understand the characteristics of HIV-infected patients in Korea. Materials and Methods: A cross-sectional study was performed to investigate clinical characteristics and prevalence of HBV and HCV infection in HIV patients enrolled in the Korea HIV/acquired immune deficiency syndrome (AIDS) cohort study from 17 institutions between December 2006 and July 2013. Results: Among the 1,218 HIV-infected participants, 541 were included in this study. The prevalence of HBV-HIV and HCV-HIV coinfection was 5.0% (27/541) and 1.7% (9/541), respectively. There was no patient who was positive for both HBs antigen and HCV antibody. In multivariate logistic regression analysis, HBV unvaccinated status was a significant risk factor for HBV-HIV coinfection (odds ratio = 4.95, 95% confidence interval = 1.43-17.13). Conclusion: HBV and HCV infection was more common in HIV-infected persons enrolled in the Korean HIV/AIDS cohort, than in the general population in Korea.

AB - Background: Despite declines in mortality and morbidity rates of patients with human immunodeficiency virus (HIV) infection as the result of highly active antiretroviral therapy, liver diseases due to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are a leading cause of death among HIV-infected patients. However, HIV and HBV or HCV coinfection is still poorly documented, and more information is needed to better understand the characteristics of HIV-infected patients in Korea. Materials and Methods: A cross-sectional study was performed to investigate clinical characteristics and prevalence of HBV and HCV infection in HIV patients enrolled in the Korea HIV/acquired immune deficiency syndrome (AIDS) cohort study from 17 institutions between December 2006 and July 2013. Results: Among the 1,218 HIV-infected participants, 541 were included in this study. The prevalence of HBV-HIV and HCV-HIV coinfection was 5.0% (27/541) and 1.7% (9/541), respectively. There was no patient who was positive for both HBs antigen and HCV antibody. In multivariate logistic regression analysis, HBV unvaccinated status was a significant risk factor for HBV-HIV coinfection (odds ratio = 4.95, 95% confidence interval = 1.43-17.13). Conclusion: HBV and HCV infection was more common in HIV-infected persons enrolled in the Korean HIV/AIDS cohort, than in the general population in Korea.

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