Objective: The aim of this study was to determine whether human milk oligosaccharides (HMOs) at 1 month predicted infant weight gain at 6 months and whether associations varied by HMO secretor status. Methods: Participants were 157 Hispanic mother-infant pairs. Human milk samples were collected at 1 month. Nineteen individual HMOs were analyzed using high-performance liquid chromatography, and secretor status was determined by the presence of 2′-fucosyllactose or lacto-N-fucopentaose (LNFP) I. Infant weight was measured at 1 and 6 months. Path analysis was used to test effects of HMO composition on infant weight gain, adjusting for maternal age, prepregnancy BMI, and infant age, sex, and birth weight. Results: In the total sample, higher LNFPII predicted lower infant weight gain (g1 = −4.1, P = 0.004); this was observed in both nonsecretor (g1 = −3.0, P = 0.006) and secretor groups (g1 = −4.7, P = 0.014). In the nonsecretor group, higher lacto-N-neotetraose (g1 = 7.6, P = 0.011) and disialyllacto-N-tetraose (g1 = 14.3, P = 0.002) predicted higher infant weight gain. There were no other associations in the secretor group. Conclusions: Our data suggest that higher LNFPII in human milk may decrease obesity risk across all infants, whereas higher lacto-N-neotetraose and disialyllacto-N-tetraose may increase obesity risk in infants of nonsecretors only.
Bibliographical noteFunding Information:
Research reported in this publication was supported by the National Institute of Child Health and Human Development (K99 HD098288) and the National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK110793). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This work was also funded by the Gerber Foundation (15PN‐013). Eunice Kennedy Shriver
© 2020 The Obesity Society.
All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics