Human prothrombin fragment 1 and 2 inhibit bFGF-induced BCE cell growth

Tai Youn Rhim, Chan Soo Park, Eunkyung Kim, Soung Soo Kim

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

Previously, we reported that the rabbit prothrombin fragment 2 (kringle 2 domain) has an anti-endothelial cell proliferative effect. In this report, we show that not only rabbit prothrombin fragment 2 but also human prothrombin fragment 1 and 2 have an inhibitory effect on bFGF-stimulated BCE cell growth. Human prothrombin fragment 1 and 2 obtained as proteolytic fragments of human prothrombin display potent inhibitory effects on bovine capillary endothelial cells with a half-maximal concentration (ED50) of approximately 100 nM and 120 nM, respectively. As rabbit prothrombin fragment 2, the human prothrombin fragment 1 and 2 also inhibit angiogenesis in the chorioallantoic membrane (CAM) of chick embryos.

Original languageEnglish
Pages (from-to)513-516
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume252
Issue number2
DOIs
Publication statusPublished - 1998 Nov 18

Bibliographical note

Funding Information:
This study was supported in part by the Korea Science and Engineering Foundation (KOSEF) through the Bioproducts Research Center at Yonsei University (98K3-0401-04-03-2) and a grant from KOSEF (project number 981-0508-042-2).

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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