Abstract
Purpose: [18F]AV-1451 is a positron emission tomography (PET) radioligand for detecting paired helical filament tau. Our aim was to estimate the radiation dose of [18F]AV-1451 in humans. Procedures: Whole-body PET scans were acquired for six healthy volunteers (three male, three female) for 128 min after injection of [18F]AV-1451 (268 ± 31 MBq). Radiation doses were estimated using the OLINDA/EXM software. Results: The estimated organ doses ranged from 7.81 to 81.2 μSv/MBq. The critical organ for radiation burden was the liver. Radiation doses to the reproductive and blood-forming organs were 14.15, 8.43, and 18.35 μSv/MBq for the ovaries, testes, and red marrow, respectively. The mean effective dose was 22.47 ± 3.59 μSv/MBq. Conclusions: A standard single injection of 185 MBq (5 mCi) results in an effective dose of 4.7 mSv in a healthy subject. Therefore, [18F]AV-1451 could be used in multiple PET scans of the same subject per year.
| Original language | English |
|---|---|
| Pages (from-to) | 479-482 |
| Number of pages | 4 |
| Journal | Molecular Imaging and Biology |
| Volume | 18 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2016 Aug 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Oncology
- Radiology Nuclear Medicine and imaging
- Cancer Research
Cite this
}
Human Radiation Dosimetry of [18F]AV-1451(T807) to Detect Tau Pathology. / Choi, Jae Yong; Lyoo, Chulhyoung; Lee, Jae Hoon; Cho, Hanna; Kim, Kyeong Min; Kim, Jin Su; Ryu, Young Hoon.
In: Molecular Imaging and Biology, Vol. 18, No. 4, 01.08.2016, p. 479-482.Research output: Contribution to journal › Article
TY - JOUR
T1 - Human Radiation Dosimetry of [18F]AV-1451(T807) to Detect Tau Pathology
AU - Choi, Jae Yong
AU - Lyoo, Chulhyoung
AU - Lee, Jae Hoon
AU - Cho, Hanna
AU - Kim, Kyeong Min
AU - Kim, Jin Su
AU - Ryu, Young Hoon
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Purpose: [18F]AV-1451 is a positron emission tomography (PET) radioligand for detecting paired helical filament tau. Our aim was to estimate the radiation dose of [18F]AV-1451 in humans. Procedures: Whole-body PET scans were acquired for six healthy volunteers (three male, three female) for 128 min after injection of [18F]AV-1451 (268 ± 31 MBq). Radiation doses were estimated using the OLINDA/EXM software. Results: The estimated organ doses ranged from 7.81 to 81.2 μSv/MBq. The critical organ for radiation burden was the liver. Radiation doses to the reproductive and blood-forming organs were 14.15, 8.43, and 18.35 μSv/MBq for the ovaries, testes, and red marrow, respectively. The mean effective dose was 22.47 ± 3.59 μSv/MBq. Conclusions: A standard single injection of 185 MBq (5 mCi) results in an effective dose of 4.7 mSv in a healthy subject. Therefore, [18F]AV-1451 could be used in multiple PET scans of the same subject per year.
AB - Purpose: [18F]AV-1451 is a positron emission tomography (PET) radioligand for detecting paired helical filament tau. Our aim was to estimate the radiation dose of [18F]AV-1451 in humans. Procedures: Whole-body PET scans were acquired for six healthy volunteers (three male, three female) for 128 min after injection of [18F]AV-1451 (268 ± 31 MBq). Radiation doses were estimated using the OLINDA/EXM software. Results: The estimated organ doses ranged from 7.81 to 81.2 μSv/MBq. The critical organ for radiation burden was the liver. Radiation doses to the reproductive and blood-forming organs were 14.15, 8.43, and 18.35 μSv/MBq for the ovaries, testes, and red marrow, respectively. The mean effective dose was 22.47 ± 3.59 μSv/MBq. Conclusions: A standard single injection of 185 MBq (5 mCi) results in an effective dose of 4.7 mSv in a healthy subject. Therefore, [18F]AV-1451 could be used in multiple PET scans of the same subject per year.
UR - http://www.scopus.com/inward/record.url?scp=84952892693&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84952892693&partnerID=8YFLogxK
U2 - 10.1007/s11307-015-0924-7
DO - 10.1007/s11307-015-0924-7
M3 - Article
VL - 18
SP - 479
EP - 482
JO - Molecular Imaging and Biology
JF - Molecular Imaging and Biology
SN - 1536-1632
IS - 4
ER -