Human Radiation Dosimetry of [18F]AV-1451(T807) to Detect Tau Pathology

Jae Yong Choi; Chul Hyoung Lyoo; Jae Hoon Lee; Hanna Cho; Kyeong Min Kim; Jin Su Kim; Young Hoon Ryu

doi:10.1007/s11307-015-0924-7

Human Radiation Dosimetry of [¹⁸F]AV-1451(T807) to Detect Tau Pathology

Jae Yong Choi, Chul Hyoung Lyoo, Jae Hoon Lee, Hanna Cho, Kyeong Min Kim, Jin Su Kim, Young Hoon Ryu

Department of Neurology

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Purpose: [¹⁸F]AV-1451 is a positron emission tomography (PET) radioligand for detecting paired helical filament tau. Our aim was to estimate the radiation dose of [¹⁸F]AV-1451 in humans. Procedures: Whole-body PET scans were acquired for six healthy volunteers (three male, three female) for 128 min after injection of [¹⁸F]AV-1451 (268 ± 31 MBq). Radiation doses were estimated using the OLINDA/EXM software. Results: The estimated organ doses ranged from 7.81 to 81.2 μSv/MBq. The critical organ for radiation burden was the liver. Radiation doses to the reproductive and blood-forming organs were 14.15, 8.43, and 18.35 μSv/MBq for the ovaries, testes, and red marrow, respectively. The mean effective dose was 22.47 ± 3.59 μSv/MBq. Conclusions: A standard single injection of 185 MBq (5 mCi) results in an effective dose of 4.7 mSv in a healthy subject. Therefore, [¹⁸F]AV-1451 could be used in multiple PET scans of the same subject per year.

Original language	English
Pages (from-to)	479-482
Number of pages	4
Journal	Molecular Imaging and Biology
Volume	18
Issue number	4
DOIs	https://doi.org/10.1007/s11307-015-0924-7
Publication status	Published - 2016 Aug 1

Bibliographical note

Publisher Copyright:
© 2015, World Molecular Imaging Society.

All Science Journal Classification (ASJC) codes

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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title = "Human Radiation Dosimetry of [18F]AV-1451(T807) to Detect Tau Pathology",

abstract = "Purpose: [18F]AV-1451 is a positron emission tomography (PET) radioligand for detecting paired helical filament tau. Our aim was to estimate the radiation dose of [18F]AV-1451 in humans. Procedures: Whole-body PET scans were acquired for six healthy volunteers (three male, three female) for 128 min after injection of [18F]AV-1451 (268 ± 31 MBq). Radiation doses were estimated using the OLINDA/EXM software. Results: The estimated organ doses ranged from 7.81 to 81.2 μSv/MBq. The critical organ for radiation burden was the liver. Radiation doses to the reproductive and blood-forming organs were 14.15, 8.43, and 18.35 μSv/MBq for the ovaries, testes, and red marrow, respectively. The mean effective dose was 22.47 ± 3.59 μSv/MBq. Conclusions: A standard single injection of 185 MBq (5 mCi) results in an effective dose of 4.7 mSv in a healthy subject. Therefore, [18F]AV-1451 could be used in multiple PET scans of the same subject per year.",

author = "Choi, {Jae Yong} and Lyoo, {Chul Hyoung} and Lee, {Jae Hoon} and Hanna Cho and Kim, {Kyeong Min} and Kim, {Jin Su} and Ryu, {Young Hoon}",

note = "Publisher Copyright: {\textcopyright} 2015, World Molecular Imaging Society.",

year = "2016",

month = aug,

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doi = "10.1007/s11307-015-0924-7",

language = "English",

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T1 - Human Radiation Dosimetry of [18F]AV-1451(T807) to Detect Tau Pathology

AU - Choi, Jae Yong

AU - Lyoo, Chul Hyoung

AU - Lee, Jae Hoon

AU - Cho, Hanna

AU - Kim, Kyeong Min

AU - Kim, Jin Su

AU - Ryu, Young Hoon

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Purpose: [18F]AV-1451 is a positron emission tomography (PET) radioligand for detecting paired helical filament tau. Our aim was to estimate the radiation dose of [18F]AV-1451 in humans. Procedures: Whole-body PET scans were acquired for six healthy volunteers (three male, three female) for 128 min after injection of [18F]AV-1451 (268 ± 31 MBq). Radiation doses were estimated using the OLINDA/EXM software. Results: The estimated organ doses ranged from 7.81 to 81.2 μSv/MBq. The critical organ for radiation burden was the liver. Radiation doses to the reproductive and blood-forming organs were 14.15, 8.43, and 18.35 μSv/MBq for the ovaries, testes, and red marrow, respectively. The mean effective dose was 22.47 ± 3.59 μSv/MBq. Conclusions: A standard single injection of 185 MBq (5 mCi) results in an effective dose of 4.7 mSv in a healthy subject. Therefore, [18F]AV-1451 could be used in multiple PET scans of the same subject per year.

AB - Purpose: [18F]AV-1451 is a positron emission tomography (PET) radioligand for detecting paired helical filament tau. Our aim was to estimate the radiation dose of [18F]AV-1451 in humans. Procedures: Whole-body PET scans were acquired for six healthy volunteers (three male, three female) for 128 min after injection of [18F]AV-1451 (268 ± 31 MBq). Radiation doses were estimated using the OLINDA/EXM software. Results: The estimated organ doses ranged from 7.81 to 81.2 μSv/MBq. The critical organ for radiation burden was the liver. Radiation doses to the reproductive and blood-forming organs were 14.15, 8.43, and 18.35 μSv/MBq for the ovaries, testes, and red marrow, respectively. The mean effective dose was 22.47 ± 3.59 μSv/MBq. Conclusions: A standard single injection of 185 MBq (5 mCi) results in an effective dose of 4.7 mSv in a healthy subject. Therefore, [18F]AV-1451 could be used in multiple PET scans of the same subject per year.

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