Human Radiation Dosimetry of [18F]AV-1451(T807) to Detect Tau Pathology

Jae Yong Choi; Chul Hyoung Lyoo; Jae Hoon Lee; Hanna Cho; Kyeong Min Kim; Jin Su Kim; Young Hoon Ryu

doi:10.1007/s11307-015-0924-7

Human Radiation Dosimetry of [¹⁸F]AV-1451(T807) to Detect Tau Pathology

Jae Yong Choi, Chul Hyoung Lyoo, Jae Hoon Lee, Hanna Cho, Kyeong Min Kim, Jin Su Kim, Young Hoon Ryu

Department of Neurology

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Purpose: [¹⁸F]AV-1451 is a positron emission tomography (PET) radioligand for detecting paired helical filament tau. Our aim was to estimate the radiation dose of [¹⁸F]AV-1451 in humans. Procedures: Whole-body PET scans were acquired for six healthy volunteers (three male, three female) for 128 min after injection of [¹⁸F]AV-1451 (268 ± 31 MBq). Radiation doses were estimated using the OLINDA/EXM software. Results: The estimated organ doses ranged from 7.81 to 81.2 μSv/MBq. The critical organ for radiation burden was the liver. Radiation doses to the reproductive and blood-forming organs were 14.15, 8.43, and 18.35 μSv/MBq for the ovaries, testes, and red marrow, respectively. The mean effective dose was 22.47 ± 3.59 μSv/MBq. Conclusions: A standard single injection of 185 MBq (5 mCi) results in an effective dose of 4.7 mSv in a healthy subject. Therefore, [¹⁸F]AV-1451 could be used in multiple PET scans of the same subject per year.

Original language	English
Pages (from-to)	479-482
Number of pages	4
Journal	Molecular Imaging and Biology
Volume	18
Issue number	4
DOIs	https://doi.org/10.1007/s11307-015-0924-7
Publication status	Published - 2016 Aug 1

Bibliographical note

Funding Information:
This research was supported by the Nuclear R&D Program of the National Research Foundation of Korea (Grant No. NRF-2015M2A2A7027110) and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2015R1C1A2A01054507). The authors express gratitude to Tae Ho Sung, Won Tak Lee and Min Soo Jeon who managed all PET scans.

Publisher Copyright:
© 2015, World Molecular Imaging Society.

All Science Journal Classification (ASJC) codes

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s11307-015-0924-7

Cite this

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title = "Human Radiation Dosimetry of [18F]AV-1451(T807) to Detect Tau Pathology",

abstract = "Purpose: [18F]AV-1451 is a positron emission tomography (PET) radioligand for detecting paired helical filament tau. Our aim was to estimate the radiation dose of [18F]AV-1451 in humans. Procedures: Whole-body PET scans were acquired for six healthy volunteers (three male, three female) for 128 min after injection of [18F]AV-1451 (268 ± 31 MBq). Radiation doses were estimated using the OLINDA/EXM software. Results: The estimated organ doses ranged from 7.81 to 81.2 μSv/MBq. The critical organ for radiation burden was the liver. Radiation doses to the reproductive and blood-forming organs were 14.15, 8.43, and 18.35 μSv/MBq for the ovaries, testes, and red marrow, respectively. The mean effective dose was 22.47 ± 3.59 μSv/MBq. Conclusions: A standard single injection of 185 MBq (5 mCi) results in an effective dose of 4.7 mSv in a healthy subject. Therefore, [18F]AV-1451 could be used in multiple PET scans of the same subject per year.",

author = "Choi, {Jae Yong} and Lyoo, {Chul Hyoung} and Lee, {Jae Hoon} and Hanna Cho and Kim, {Kyeong Min} and Kim, {Jin Su} and Ryu, {Young Hoon}",

note = "Funding Information: This research was supported by the Nuclear R&D Program of the National Research Foundation of Korea (Grant No. NRF-2015M2A2A7027110) and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2015R1C1A2A01054507). The authors express gratitude to Tae Ho Sung, Won Tak Lee and Min Soo Jeon who managed all PET scans. Publisher Copyright: {\textcopyright} 2015, World Molecular Imaging Society.",

year = "2016",

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doi = "10.1007/s11307-015-0924-7",

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T1 - Human Radiation Dosimetry of [18F]AV-1451(T807) to Detect Tau Pathology

AU - Choi, Jae Yong

AU - Lyoo, Chul Hyoung

AU - Lee, Jae Hoon

AU - Cho, Hanna

AU - Kim, Kyeong Min

AU - Kim, Jin Su

AU - Ryu, Young Hoon

N1 - Funding Information: This research was supported by the Nuclear R&D Program of the National Research Foundation of Korea (Grant No. NRF-2015M2A2A7027110) and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2015R1C1A2A01054507). The authors express gratitude to Tae Ho Sung, Won Tak Lee and Min Soo Jeon who managed all PET scans. Publisher Copyright: © 2015, World Molecular Imaging Society.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Purpose: [18F]AV-1451 is a positron emission tomography (PET) radioligand for detecting paired helical filament tau. Our aim was to estimate the radiation dose of [18F]AV-1451 in humans. Procedures: Whole-body PET scans were acquired for six healthy volunteers (three male, three female) for 128 min after injection of [18F]AV-1451 (268 ± 31 MBq). Radiation doses were estimated using the OLINDA/EXM software. Results: The estimated organ doses ranged from 7.81 to 81.2 μSv/MBq. The critical organ for radiation burden was the liver. Radiation doses to the reproductive and blood-forming organs were 14.15, 8.43, and 18.35 μSv/MBq for the ovaries, testes, and red marrow, respectively. The mean effective dose was 22.47 ± 3.59 μSv/MBq. Conclusions: A standard single injection of 185 MBq (5 mCi) results in an effective dose of 4.7 mSv in a healthy subject. Therefore, [18F]AV-1451 could be used in multiple PET scans of the same subject per year.

AB - Purpose: [18F]AV-1451 is a positron emission tomography (PET) radioligand for detecting paired helical filament tau. Our aim was to estimate the radiation dose of [18F]AV-1451 in humans. Procedures: Whole-body PET scans were acquired for six healthy volunteers (three male, three female) for 128 min after injection of [18F]AV-1451 (268 ± 31 MBq). Radiation doses were estimated using the OLINDA/EXM software. Results: The estimated organ doses ranged from 7.81 to 81.2 μSv/MBq. The critical organ for radiation burden was the liver. Radiation doses to the reproductive and blood-forming organs were 14.15, 8.43, and 18.35 μSv/MBq for the ovaries, testes, and red marrow, respectively. The mean effective dose was 22.47 ± 3.59 μSv/MBq. Conclusions: A standard single injection of 185 MBq (5 mCi) results in an effective dose of 4.7 mSv in a healthy subject. Therefore, [18F]AV-1451 could be used in multiple PET scans of the same subject per year.

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