Human Radiation Dosimetry of [18F]AV-1451(T807) to Detect Tau Pathology

Jae Yong Choi, Chulhyoung Lyoo, Jae Hoon Lee, Hanna Cho, Kyeong Min Kim, Jin Su Kim, Young Hoon Ryu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: [18F]AV-1451 is a positron emission tomography (PET) radioligand for detecting paired helical filament tau. Our aim was to estimate the radiation dose of [18F]AV-1451 in humans. Procedures: Whole-body PET scans were acquired for six healthy volunteers (three male, three female) for 128 min after injection of [18F]AV-1451 (268 ± 31 MBq). Radiation doses were estimated using the OLINDA/EXM software. Results: The estimated organ doses ranged from 7.81 to 81.2 μSv/MBq. The critical organ for radiation burden was the liver. Radiation doses to the reproductive and blood-forming organs were 14.15, 8.43, and 18.35 μSv/MBq for the ovaries, testes, and red marrow, respectively. The mean effective dose was 22.47 ± 3.59 μSv/MBq. Conclusions: A standard single injection of 185 MBq (5 mCi) results in an effective dose of 4.7 mSv in a healthy subject. Therefore, [18F]AV-1451 could be used in multiple PET scans of the same subject per year.

Original languageEnglish
Pages (from-to)479-482
Number of pages4
JournalMolecular Imaging and Biology
Volume18
Issue number4
DOIs
Publication statusPublished - 2016 Aug 1

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Radiometry
Positron-Emission Tomography
Radiation
Pathology
Healthy Volunteers
Injections
Testis
Ovary
Software
Bone Marrow
Liver

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Choi, Jae Yong ; Lyoo, Chulhyoung ; Lee, Jae Hoon ; Cho, Hanna ; Kim, Kyeong Min ; Kim, Jin Su ; Ryu, Young Hoon. / Human Radiation Dosimetry of [18F]AV-1451(T807) to Detect Tau Pathology. In: Molecular Imaging and Biology. 2016 ; Vol. 18, No. 4. pp. 479-482.
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Human Radiation Dosimetry of [18F]AV-1451(T807) to Detect Tau Pathology. / Choi, Jae Yong; Lyoo, Chulhyoung; Lee, Jae Hoon; Cho, Hanna; Kim, Kyeong Min; Kim, Jin Su; Ryu, Young Hoon.

In: Molecular Imaging and Biology, Vol. 18, No. 4, 01.08.2016, p. 479-482.

Research output: Contribution to journalArticle

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AU - Cho, Hanna

AU - Kim, Kyeong Min

AU - Kim, Jin Su

AU - Ryu, Young Hoon

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N2 - Purpose: [18F]AV-1451 is a positron emission tomography (PET) radioligand for detecting paired helical filament tau. Our aim was to estimate the radiation dose of [18F]AV-1451 in humans. Procedures: Whole-body PET scans were acquired for six healthy volunteers (three male, three female) for 128 min after injection of [18F]AV-1451 (268 ± 31 MBq). Radiation doses were estimated using the OLINDA/EXM software. Results: The estimated organ doses ranged from 7.81 to 81.2 μSv/MBq. The critical organ for radiation burden was the liver. Radiation doses to the reproductive and blood-forming organs were 14.15, 8.43, and 18.35 μSv/MBq for the ovaries, testes, and red marrow, respectively. The mean effective dose was 22.47 ± 3.59 μSv/MBq. Conclusions: A standard single injection of 185 MBq (5 mCi) results in an effective dose of 4.7 mSv in a healthy subject. Therefore, [18F]AV-1451 could be used in multiple PET scans of the same subject per year.

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