Hyaluronic acid (HA), an essential component of extracellular matrix (ECM), plays an important role in various cellular activities, including migration, proliferation, and differentiation. Not only its structural and biological properties, but also properties such as biocompatibility, biodegradability, and low immunogenicity make HA a promising biomaterial for tissue engineering and regenerative medicine. HA has been widely utilized as a hydrogel to form complex polymer networks, which can be chemically modified owing to the abundance of functional groups. To closely recapitulate native tissues, many approaches have been developed through chemical modification, incorporation of various biomaterials and biomolecules based on biomimetics, and fabrication techniques. Thus, HA-based hydrogels can be designed to exhibit specific properties or functions for targeted tissues, capable of maintaining or replacing structural and biological properties. This review highlights recent efforts in developing HA-based hydrogels as ECM-mimetic scaffolds and bio-inspired functional biomaterials in the fields of tissue engineering and regenerative medicine as well as their medical applications.
|Number of pages||14|
|Journal||Biotechnology and Bioprocess Engineering|
|Publication status||Published - 2021 Aug|
Bibliographical noteFunding Information:
S.A. and S.C. contributed equally to this work. The authors sincerely thank Sooyeon Kim of Yonsei University for her support in preparing the illustrations. This work was supported by the Bio & Medical Technology Development Program (2020M3A9I4038455) of the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (MSIT), Republic of Korea. This work was also supported by the Technology Innovation Program (Alchemist Project, 20012378) funded by the Ministry of Trade, Industry & Energy (MOTIE), Republic of Korea. The authors declare no conflict of interest.
© 2021, The Korean Society for Biotechnology and Bioengineering and Springer.
All Science Journal Classification (ASJC) codes
- Applied Microbiology and Biotechnology
- Biomedical Engineering