Hyaluronic acid-conjugated mesoporous silica nanoparticles loaded with dual anticancer agents for chemophotodynamic cancer therapy

Sanghyo Park, Hyungkyu Park, Seokhyeon Jeong, Bong Gu Yi, Kyeongsoon Park, Jaehong Key

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Present cancer treatments using chemotherapy are limited owing to both significant side effects to normal cells and high recurrence rates. In this study, we demonstrated cancer cell-targeting nanoparticles that load multiple anticancer agents for both specific treatments to cancer and substantial therapeutic effects. For this purpose, hyaluronic acid (HA) was conjugated to mesoporous silica nanoparticles (MSNs) for specifically targeting cancer cells. Moreover, the prepared HA-MSNs exhibited high drug loading potential and sustained drug release. Compared to bare MSNs, the HA-MSNs were internalized at an approximately three times higher rate in squamous cell carcinoma 7 (SCC7) cells. To enhance the anticancer effects of chemotherapy and photodynamic therapy (PDT), doxorubicin (DOX) and chlorin e6 (Ce6) were loaded in HA-MSNs (DOX/Ce6/HA-MSNs); the product exhibited highly effective cytotoxicity on green fluorescent protein-expressing squamous cell carcinoma 7 (SCC7) compared to the corresponding free drugs and HA-MSNs with DOX or Ce6 alone. This study indicates that the application of DOX/Ce6/HA-MSNs in chemotherapy and PDT exerts significant therapeutic effects against SCC7.

Original languageEnglish
Article number3481397
JournalJournal of Nanomaterials
Volume2019
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Hyaluronic acid
Hyaluronic Acid
Silicon Dioxide
Antineoplastic Agents
Silica
Nanoparticles
Doxorubicin
Chemotherapy
Photodynamic therapy
Cells
Pharmaceutical Preparations
Oncology
Cytotoxicity
Green Fluorescent Proteins
Proteins

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

@article{fad72619ac2043379f57af052a987af6,
title = "Hyaluronic acid-conjugated mesoporous silica nanoparticles loaded with dual anticancer agents for chemophotodynamic cancer therapy",
abstract = "Present cancer treatments using chemotherapy are limited owing to both significant side effects to normal cells and high recurrence rates. In this study, we demonstrated cancer cell-targeting nanoparticles that load multiple anticancer agents for both specific treatments to cancer and substantial therapeutic effects. For this purpose, hyaluronic acid (HA) was conjugated to mesoporous silica nanoparticles (MSNs) for specifically targeting cancer cells. Moreover, the prepared HA-MSNs exhibited high drug loading potential and sustained drug release. Compared to bare MSNs, the HA-MSNs were internalized at an approximately three times higher rate in squamous cell carcinoma 7 (SCC7) cells. To enhance the anticancer effects of chemotherapy and photodynamic therapy (PDT), doxorubicin (DOX) and chlorin e6 (Ce6) were loaded in HA-MSNs (DOX/Ce6/HA-MSNs); the product exhibited highly effective cytotoxicity on green fluorescent protein-expressing squamous cell carcinoma 7 (SCC7) compared to the corresponding free drugs and HA-MSNs with DOX or Ce6 alone. This study indicates that the application of DOX/Ce6/HA-MSNs in chemotherapy and PDT exerts significant therapeutic effects against SCC7.",
author = "Sanghyo Park and Hyungkyu Park and Seokhyeon Jeong and Yi, {Bong Gu} and Kyeongsoon Park and Jaehong Key",
year = "2019",
month = "1",
day = "1",
doi = "10.1155/2019/3481397",
language = "English",
volume = "2019",
journal = "Journal of Nanomaterials",
issn = "1687-4110",
publisher = "Hindawi Publishing Corporation",

}

Hyaluronic acid-conjugated mesoporous silica nanoparticles loaded with dual anticancer agents for chemophotodynamic cancer therapy. / Park, Sanghyo; Park, Hyungkyu; Jeong, Seokhyeon; Yi, Bong Gu; Park, Kyeongsoon; Key, Jaehong.

In: Journal of Nanomaterials, Vol. 2019, 3481397, 01.01.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hyaluronic acid-conjugated mesoporous silica nanoparticles loaded with dual anticancer agents for chemophotodynamic cancer therapy

AU - Park, Sanghyo

AU - Park, Hyungkyu

AU - Jeong, Seokhyeon

AU - Yi, Bong Gu

AU - Park, Kyeongsoon

AU - Key, Jaehong

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Present cancer treatments using chemotherapy are limited owing to both significant side effects to normal cells and high recurrence rates. In this study, we demonstrated cancer cell-targeting nanoparticles that load multiple anticancer agents for both specific treatments to cancer and substantial therapeutic effects. For this purpose, hyaluronic acid (HA) was conjugated to mesoporous silica nanoparticles (MSNs) for specifically targeting cancer cells. Moreover, the prepared HA-MSNs exhibited high drug loading potential and sustained drug release. Compared to bare MSNs, the HA-MSNs were internalized at an approximately three times higher rate in squamous cell carcinoma 7 (SCC7) cells. To enhance the anticancer effects of chemotherapy and photodynamic therapy (PDT), doxorubicin (DOX) and chlorin e6 (Ce6) were loaded in HA-MSNs (DOX/Ce6/HA-MSNs); the product exhibited highly effective cytotoxicity on green fluorescent protein-expressing squamous cell carcinoma 7 (SCC7) compared to the corresponding free drugs and HA-MSNs with DOX or Ce6 alone. This study indicates that the application of DOX/Ce6/HA-MSNs in chemotherapy and PDT exerts significant therapeutic effects against SCC7.

AB - Present cancer treatments using chemotherapy are limited owing to both significant side effects to normal cells and high recurrence rates. In this study, we demonstrated cancer cell-targeting nanoparticles that load multiple anticancer agents for both specific treatments to cancer and substantial therapeutic effects. For this purpose, hyaluronic acid (HA) was conjugated to mesoporous silica nanoparticles (MSNs) for specifically targeting cancer cells. Moreover, the prepared HA-MSNs exhibited high drug loading potential and sustained drug release. Compared to bare MSNs, the HA-MSNs were internalized at an approximately three times higher rate in squamous cell carcinoma 7 (SCC7) cells. To enhance the anticancer effects of chemotherapy and photodynamic therapy (PDT), doxorubicin (DOX) and chlorin e6 (Ce6) were loaded in HA-MSNs (DOX/Ce6/HA-MSNs); the product exhibited highly effective cytotoxicity on green fluorescent protein-expressing squamous cell carcinoma 7 (SCC7) compared to the corresponding free drugs and HA-MSNs with DOX or Ce6 alone. This study indicates that the application of DOX/Ce6/HA-MSNs in chemotherapy and PDT exerts significant therapeutic effects against SCC7.

UR - http://www.scopus.com/inward/record.url?scp=85073892612&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073892612&partnerID=8YFLogxK

U2 - 10.1155/2019/3481397

DO - 10.1155/2019/3481397

M3 - Article

AN - SCOPUS:85073892612

VL - 2019

JO - Journal of Nanomaterials

JF - Journal of Nanomaterials

SN - 1687-4110

M1 - 3481397

ER -