This animal experimental study reports one case of hybrid transvaginal natural orifice transluminal endoscopic surgery (NOTES) for nephrectomy. We performed a nephrectomy through a transvaginal access and 2 additional 5 mm trocars in the abdomen by using the keyhole technique. The specimen was removed through the vaginal tract. The total procedure time was 102 minutes. There were no intraoperative complications.
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