Hydrazinocurcumin, a novel synthetic curcumin derivative, Is a potent inhibitor of endothelial cell proliferation

Joong Sup Shim, Dong Hoon Kim, Hye Jin Jung, Jin Hee Kim, Dongyeol Lim, Seok Ki Lee, Kyu Won Kim, Jong Woong Ahn, Jong Shin Yoo, Jung Rae Rho, Jongheon Shin, Ho Jeong Kwon

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Abstract

Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC50=520 nM) without cytotoxicity. In vivo and in vitro angiogenesis experiments showed HC as a new candidate for anti-angiogenic agent.

Original languageEnglish
Pages (from-to)2439-2444
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume10
Issue number8
DOIs
Publication statusPublished - 2002 Jun 24

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Sup Shim, J., Hoon Kim, D., Jung, H. J., Hee Kim, J., Lim, D., Lee, S. K., Kim, K. W., Ahn, J. W., Yoo, J. S., Rho, J. R., Shin, J., & Jeong Kwon, H. (2002). Hydrazinocurcumin, a novel synthetic curcumin derivative, Is a potent inhibitor of endothelial cell proliferation. Bioorganic and Medicinal Chemistry, 10(8), 2439-2444. https://doi.org/10.1016/S0968-0896(02)00116-5