Hydrazinocurcumin, a novel synthetic curcumin derivative, Is a potent inhibitor of endothelial cell proliferation

Joong Sup Shim, Dong Hoon Kim, Hye Jin Jung, Jin Hee Kim, Dongyeol Lim, Seok Ki Lee, Kyu Won Kim, Jong Woong Ahn, Jong Shin Yoo, Jung Rae Rho, Jongheon Shin, Ho Jeong Kwon

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC50=520 nM) without cytotoxicity. In vivo and in vitro angiogenesis experiments showed HC as a new candidate for anti-angiogenic agent.

Original languageEnglish
Pages (from-to)2439-2444
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume10
Issue number8
DOIs
Publication statusPublished - 2002

Bibliographical note

Funding Information:
This work was supported by a grant to HJK from Korea Health 21 R&D Project, Ministry of Health & Welfare (HMP-01-PJ1-PG1–01CH04–0005) and to JS from the Ministry of Science and Technology of Korea (PN 99384). We are grateful to Dr. Jo at the KNIH for BAECs.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Hydrazinocurcumin, a novel synthetic curcumin derivative, Is a potent inhibitor of endothelial cell proliferation'. Together they form a unique fingerprint.

Cite this