Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC50=520 nM) without cytotoxicity. In vivo and in vitro angiogenesis experiments showed HC as a new candidate for anti-angiogenic agent.
Bibliographical noteFunding Information:
This work was supported by a grant to HJK from Korea Health 21 R&D Project, Ministry of Health & Welfare (HMP-01-PJ1-PG1–01CH04–0005) and to JS from the Ministry of Science and Technology of Korea (PN 99384). We are grateful to Dr. Jo at the KNIH for BAECs.
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry