Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation

Joong Sup Shim, Dong Hoon Kim, Hye Jin Jung, Jin Hee Kim, Dongyeol Lim, Seok Ki Lee, Kyu Won Kim, Jong Woong Ahn, Jong Shin Yoo, Jung Rae Rho, Jongheon Shin, Ho Jeong Kwon

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC50=520 nM) without cytotoxicity. In vivo and in vitro angiogenesis experiments showed HC as a new candidate for anti-angiogenic agent.

Original languageEnglish
Pages (from-to)2987-2992
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume10
Issue number9
DOIs
Publication statusPublished - 2002 Jan 1

Fingerprint

Curcumin
Endothelial cells
Cell proliferation
Endothelial Cells
Cell Proliferation
Derivatives
Angiogenesis Inhibitors
Cytotoxicity
Bioactivity
Inhibitory Concentration 50
hydrazinocurcumin
Experiments

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Shim, Joong Sup ; Kim, Dong Hoon ; Jung, Hye Jin ; Kim, Jin Hee ; Lim, Dongyeol ; Lee, Seok Ki ; Kim, Kyu Won ; Ahn, Jong Woong ; Yoo, Jong Shin ; Rho, Jung Rae ; Shin, Jongheon ; Kwon, Ho Jeong. / Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation. In: Bioorganic and Medicinal Chemistry. 2002 ; Vol. 10, No. 9. pp. 2987-2992.
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abstract = "Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC50=520 nM) without cytotoxicity. In vivo and in vitro angiogenesis experiments showed HC as a new candidate for anti-angiogenic agent.",
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Shim, JS, Kim, DH, Jung, HJ, Kim, JH, Lim, D, Lee, SK, Kim, KW, Ahn, JW, Yoo, JS, Rho, JR, Shin, J & Kwon, HJ 2002, 'Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation', Bioorganic and Medicinal Chemistry, vol. 10, no. 9, pp. 2987-2992. https://doi.org/10.1016/S0968-0896(02)00129-3

Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation. / Shim, Joong Sup; Kim, Dong Hoon; Jung, Hye Jin; Kim, Jin Hee; Lim, Dongyeol; Lee, Seok Ki; Kim, Kyu Won; Ahn, Jong Woong; Yoo, Jong Shin; Rho, Jung Rae; Shin, Jongheon; Kwon, Ho Jeong.

In: Bioorganic and Medicinal Chemistry, Vol. 10, No. 9, 01.01.2002, p. 2987-2992.

Research output: Contribution to journalArticle

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AU - Shim, Joong Sup

AU - Kim, Dong Hoon

AU - Jung, Hye Jin

AU - Kim, Jin Hee

AU - Lim, Dongyeol

AU - Lee, Seok Ki

AU - Kim, Kyu Won

AU - Ahn, Jong Woong

AU - Yoo, Jong Shin

AU - Rho, Jung Rae

AU - Shin, Jongheon

AU - Kwon, Ho Jeong

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