Hydroacylation of 1-alkene with a heteroaromatic aldehyde such as pyridinecarboxaldehyde, thiophenecarboxaldehyde and furfural derivatives under cocatalyst of Wilkinson's complex and 2-amino-3-picoline gave poor yield of hydroacylated product. The addition of a catalytic amount of bis(cyclopentadienyl)zirconium dichloride or bis(cyclopentadienyl)titanium dichloride as an additive dramatically increased the yield of the hydroacylated ketone product.
Bibliographical noteFunding Information:
This study was supported in part by the Basic Science Research Institute Program, Ministry of Education (Project No. BSRI-96-3422) and the Korea Science and Engineering Foundation (Grant 961-0306-054-2).
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry