Hydroacylation of 1-alkene with heteroaromatic aldehyde by Rh(I) and additives

Chul Ho Jun, Dae Yon Lee, Jun Bae Hong

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

Hydroacylation of 1-alkene with a heteroaromatic aldehyde such as pyridinecarboxaldehyde, thiophenecarboxaldehyde and furfural derivatives under cocatalyst of Wilkinson's complex and 2-amino-3-picoline gave poor yield of hydroacylated product. The addition of a catalytic amount of bis(cyclopentadienyl)zirconium dichloride or bis(cyclopentadienyl)titanium dichloride as an additive dramatically increased the yield of the hydroacylated ketone product.

Original languageEnglish
Pages (from-to)6673-6676
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number38
DOIs
Publication statusPublished - 1997 Sep 22

Bibliographical note

Funding Information:
This study was supported in part by the Basic Science Research Institute Program, Ministry of Education (Project No. BSRI-96-3422) and the Korea Science and Engineering Foundation (Grant 961-0306-054-2).

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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