Hydroacylation of 4-[18F]fluorobenzaldehyde: A novel method for the preparation of 4′-[18F]phenylketones

Noor Ul Hasan Khan, Byung Chul Lee, Sang Yoon Lee, Yearn Seong Choe, Chul Ho Jun, Dae Yoon Chi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To assess the potential of intermolecular hydroacylation reactions as a new fluorine-18 labeling method, model reactions of [18F]fluorobenzaldehyde with three different olefins (1-hexene (2a), allylbenzene (2b), and 3-phenoxypropene (2c)) in the presence of Wilkinson's catalyst were performed. The procedure gave high radiochemical yields (38-62%) of [18F]fluorophenylketones with short reaction times (15 min). The intermolecular hydroacylation reaction provides a new method for the preparation of fluorine-18 labeled compounds.

Original languageEnglish
Pages (from-to)1045-1053
Number of pages9
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume45
Issue number12
DOIs
Publication statusPublished - 2002 Oct 30

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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